Biomimetic and Antioxidant Activity of Nanocrystalline Cerium Dioxide

Цехмістренко, Оксана Сергіївна; Tsekhmistrenko, Svitlana; Melnichenko, V S O M Bityutskyy; Oleshko, O.

doi:10.26724/2079-8334-2018-1-63-196-201

Cited by 15 publications

(2 citation statements)

References 33 publications

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“…Thanks to the "greening" of the processes of synthesis of nanoparticles using biological systems and their components, there is a decrease in the load on the environment and an increase in economic efficiency, which opens up additional opportunities for the creation of nanoparticles with a given composition and properties. Each nanosystem is unique and specific in its formulation, compatibility with active molecules, choice of excipients and kinetics, as well as biological effectiveness (Tsekhmistrenko et al, 2018;Dhapte & Pokharkar, 2019;Tsekhmistrenko et al, 2020a).…”

Section: Nanoparticles As Inducers (Activators and Inhibitors)mentioning

confidence: 99%

Regulation of redox processes in biological systems with the participation of the Keap1/Nrf2/ARE signaling pathway, biogenic selenium nanoparticles as Nrf2 activators

Bityutskyy

Tsekhmistrenko

Цехмістренко

et al. 2020

Regul. Mech. Biosyst.

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The article is devoted to the mechanisms of regulation of redox processes in cells, a review of the Keap1 / Nrf2 / ARE redox-sensitive signaling system as a fundamental pathway that plays a key role in maintaining cellular redox homeostasis under stressful, inflammatory, carcinogenic and proapoptotic conditions. The structure of the cysteine-rich repressor protein Keap1, which is responsible for sensory perception of electrophiles and reactive oxygen species, the structure and functions of the transcription factor Nrf2, mechanisms of Nrf2 activation through the Keap1 / Nrf2 / ARE signaling system, which regulates the transcription and expression of cellular cytoprotective and antioxidant proteins, are described. Published data on the specificity of the interaction of the components of this cellular signaling pathway, the mechanisms of Keap1 dependent and independent adaptive response to the action of inductors, the role of biogenic selenium nanoparticles synthesized by green chemistry with the participation of bacteria in these processes are analyzed; features of Nrf2 induction depending on the type of bacteria and the stabilizing shell. It has been shown that biogenic selenium nanoparticles (BNSe), synthesized by different types of bacteria, activate the transcription factor Nrf2 using the Keap1-independent activation pathway through mitogen-protein kinases (MAPK): p38, ERK1 / 2 and AKT-mediated phosphorylation of Nrf2, protect the intestinal epithelial barrier function from the effects of oxidative damage, normalize mitochondrial function. A detailed understanding of thiol-dependent and independent redox signaling mechanisms under physiological and pathological conditions will lead to a deeper understanding of the redox component in human and animal diseases. The use of biogenic nanoselen, synthesized with the participation of various bacterial species, has been demonstrated to activate the Keap1 / Nrf2 / ARE signaling pathway, which may be of practical interest as a therapeutic target for many redox-mediated diseases.

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Section: Nanoparticles As Inducers (Activators and Inhibitors)mentioning

confidence: 99%

Regulation of redox processes in biological systems with the participation of the Keap1/Nrf2/ARE signaling pathway, biogenic selenium nanoparticles as Nrf2 activators

Bityutskyy

Tsekhmistrenko

Цехмістренко

et al. 2020

Regul. Mech. Biosyst.

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“…The first factor ensures the comparative safety of using cerium dioxide nanoparticles in vivo. The second determines the activity of nanodispersed CeO 2 in redox processes in a living cell, especially in the case of inactivation of active forms of oxygen [19,27]. Specific properties of CeO 2 include the ability to regenerate oxygen non-stoichiometry, which is expressed in the ability of cerium dioxide nanoparticles to return to their initial state after participating in the redox process in a relatively short period of time, which provides the possibility of their multiple use [12,18].…”

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confidence: 99%

Effect of cerium dioxide nanoparticles on metabolic processes in the body of broiler chickens

Цехмістренко

Bityutskyy

Tsekhmistrenko

et al. 2022

Tehnologìâ virobnictva ì pererobki produktìv tvarinnictva

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The scope of application of cerium dioxide and its special physical and chemical properties are considered in the work. The effect of the size factor on the properties of nanodispersed cerium dioxide determines the biological activity of the material, low toxicity and high oxygen non-stoichiometry. Specific properties of CeO2 include the ability to regenerate oxygen non-stoichiometry, which is expressed in the ability of cerium dioxide nanoparticles to return to their initial state after participating in the redox process in a relatively short period of time, which enables their repeated use. Nanoparticles, due to their small size, easily penetrate into the body through the respiratory, digestive, and skin organs and exhibit more pronounced biological activity due to the large surface area per unit mass. The change in the physical and chemical mechanisms of action of nanoparticles is due to the fact that most of the atoms are on the surface. Such an arrangement changes the physical, chemical, biological, toxicological properties of the substance and facilitates the interaction of nanoparticles with a living organism. Once inside a biological system, nanoparticles come into contact with a number of physical and chemical features of the organism, which affect their properties and can change the response. These features are largely due to the ability to pass through the redox cycle between two natural oxidation states (Ce3+ and Ce4+). The influence of cerium dioxide nanoparticles on metabolic processes in the body of broiler chickens has been established. Their introduction contributed to an increase in the content of total lipids in the blood by 24.6–31.3 %, albumins – by 16–22 %, and a decrease in the content of uric acid to the level of 63–67 % of the control. Non-toxicity of poultry meat treated with nano-cerium for consumers was established. The high degree of biocompatibility, low toxicity and catalytic activity of nanodispersed cerium dioxide make it possible to consider it as a promising nanobiomaterial for use in biology, medicine and agriculture. Key words: nanobiotechnologies, nanoparticles, ceriumdioxide, layinghens, lipids.

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Surface Chemistry of Biologically Active Reducible Oxide Nanozymes

et al. 2023

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Reducible metal oxide nanozymes (rNZs) have been a subject of intense recent interest due to their catalytic nature, ease of synthesis, and complex surface character. Such materials contain surface sites which facilitate enzyme‐mimetic reactions via substrate coordination and redox cycling. Further, these surface reactive sites have been shown to be highly sensitive to stresses within the nanomaterial lattice, the physicochemical environment, and to processing conditions occurring as part of their syntheses. When administered in vivo, a complex protein corona binds to the surface, redefining its biological identity and subsequent interactions within the biological system. Catalytic activities of rNZs each deliver a differing impact on protein corona formation, its composition, and in turn, their recognition, and internalization by host cells. Improving our understanding of the precise principles that dominate rNZ surface‐biomolecule adsorption raises the question of whether designer rNZs can be engineered to prevent corona formation, or indeed to produce “custom” protein coronas applied either in vitro, and pre‐administration, or formed immediately upon their exposure to body fluids. Here, we consider fundamental surface chemistry processes and their implications in rNZ material performance. In particular, we discuss material structures which inform component adsorption from the application environment, including substrates for enzyme‐mimetic reactions.This article is protected by copyright. All rights reserved

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Biomimetic and Antioxidant Activity of Nanocrystalline Cerium Dioxide

Cited by 15 publications

References 33 publications

Regulation of redox processes in biological systems with the participation of the Keap1/Nrf2/ARE signaling pathway, biogenic selenium nanoparticles as Nrf2 activators

Regulation of redox processes in biological systems with the participation of the Keap1/Nrf2/ARE signaling pathway, biogenic selenium nanoparticles as Nrf2 activators

Effect of cerium dioxide nanoparticles on metabolic processes in the body of broiler chickens

Surface Chemistry of Biologically Active Reducible Oxide Nanozymes

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