Biomimesis and biomorphic transformations: New concepts applied to bone regeneration

Sprio, Simone; Ruffini, Andrea; Valentini, Federica; D’Alessandro, Teresa; Sandri, Monica; Panseri, Silvia; Tampieri, Anna

doi:10.1016/j.jbiotec.2011.07.034

Cited by 48 publications

(32 citation statements)

References 58 publications

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“…the quiescent bone cells embedded in the bone matrix) should act as mechano-sensors that respond to the shearing forces taking place upon variation of the interstitial fl uid fl ow through the bone canaliculi (Sikavitsas et al , 2001). At this point, a complex response is induced by the hierarchical organization of bone porosity and its anisotropic elastic properties (Sprio et al , 2010). These fl ow variations generate electric potentials that deform the cell membranes; these deformations act in turn as stimuli for the osteocytes to release the biochemical signals that drive tissue regeneration and remodelling.…”

Section: Biomorphic Transformation To Achieve Hierarchically Organizementioning

confidence: 99%

“…Connective tissues can regenerate only in the presence of scaffolds that are able to direct cell activity towards suitable phenotypes and to chemically and structurally assist the regeneration process (Yannas, 2001). In the case of hard tissues such as bone, this requires the synthesis of three-dimensional (3D) constructs that are able to exchange chemical signals promoting osteogenesis and can then be progressively resorbed during the formation and remodelling of new tissue (Sprio et al , 2010). Moreover, particularly when the regeneration of extensive portions of bone is involved, morphological and mechanical biomimesis is also required, in order to allow cell colonization and the formation of a proper vascularization network.…”

Section: Introductionmentioning

confidence: 99%

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Biomimetic materials in regenerative medicine

Sprio

Sandri

Iafisco

et al. 2013

Biomimetic Biomaterials

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Section: Biomorphic Transformation To Achieve Hierarchically Organizementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biomimetic materials in regenerative medicine

Sprio

Sandri

Iafisco

et al. 2013

Biomimetic Biomaterials

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“…Wollastonite is expected to induce osteogenesis by satisfying all these criteria, hence it can be used as an artificial bone implant material. 19,20 The various synthetic methods employed for the preparation of wollastonite are solid-state, 21 hydrothermal, 22 coprecipitation, 23 and solution combustion synthesis. 24 The most widely used method for the preparation of wollastonite is the sol-gel method, as the synthesized particles are homogeneous and the particles were found to be in the nano-regime.…”

Section: Introductionmentioning

confidence: 99%

Influence of needle-like morphology on the bioactivity of nanocrystalline wollastonite – an in vitro study

Lakshmi¹,

Swamiappan²

2015

IJN

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In the past 2 decades, wollastonite has been studied thoroughly for its application as a bone implant material due to its biocompatibility, high mechanical strength, and excellent bioactivity when compared to calcium phosphates bioceramics. Wollastonite was prepared through the low-temperature sol-gel combustion method using urea as the fuel, nitrate ions and nitric acid as the oxidizer. Calcium nitrate and tetraethyl orthosilicate were taken as the source of calcium and silica. The synthesized wollastonite were characterized by Fourier transform infrared spectroscopy for the identification of characteristic functional group and powder X-ray diffraction for the phase identification. Employing urea as a fuel resulted in needle-like morphology of the particles, which was confirmed by scanning electron microscopy and transmission electron microscopy. It was observed that the needle-like morphology enhances the mechanical properties such as elasticity and compressive strength and also increases the surface area of the material, which could help in a rapid deposition of hydroxyapatite layer. These properties of wollastonite warrant its application as a new artificial bone material in the field of hard tissue engineering.

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“…However, in spite of its ability of spontaneous regeneration that allows for healing of bone lesions of non-critical size, in case of large defects and osseous congenital deformities, a bone graft or bone substitute is needed to assist healing and regeneration of well-organized bone [1][2][3][4][5]. In this respect, the use of bioactive porous scaffolds associated with tissue engineering strategies has attracted many scientists and surgeons in the last two decades, in the perspective of treating patients by minimally invasive and less painful surgery.…”

Section: Introductionmentioning

confidence: 99%

Porous Hydroxyapatite-Magnetite Composites as Carriers For Guided Bone Regeneration

Sprio¹,

Panseri²,

Adamiano³

et al. 2017

Front Nanosci Nanotech

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Regeneration of critical size bone defects is still a major concern in orthopedics and requires the use of porous scaffolds with osteogenic and osteoconductive ability, able to boost cell activity towards the regenerative cascade. Even though magnetic-based targeted therapies for bone regeneration are very promising, they are affected by the low penetrating capacity of externally applied magnetic fields to reach the therapeutic site inside the human body. A strategy to overcome this pitfall is to implant magnetic scaffolds sensitive to magnetic stimulation or capable to be remotely activated by a calibrated magnetic field inside the patient body. In this work, we report on highly porous and magnetic scaffolds obtained by foaming process, consisting in hydroxyapatite matrices added with increasing amounts of magnetite nanoparticles. Extensive characterization of compositional, morphological, mechanical and magnetic properties was carried out, as well as a number of biological assays to extensively evaluate biological performances. The sintering temperature affected the magnetic properties of the materials by determining the phase transformation of magnetite into weakly magnetic or diamagnetic iron oxide phases such as hematite. However, this phenomenon was relevant only for scaffolds with a 50 wt% of magnetite, while below this value the hydroxyapatite matrix protected the magnetic phase from this transformation, thus ensuring the retention of valuable magnetic characteristics. The porous scaffolds exhibited good mechanical strength and magnetic properties enabling uses in hyperthermia-based therapies, displaying also high biocompatibility and cell conductivity into the inner part of the scaffold thanks to high open and interconnected submicro-ultramacro porosity.

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Biomimesis and biomorphic transformations: New concepts applied to bone regeneration

Cited by 48 publications

References 58 publications

Biomimetic materials in regenerative medicine

Biomimetic materials in regenerative medicine

Influence of needle-like morphology on the bioactivity of nanocrystalline wollastonite – an in vitro study

Porous Hydroxyapatite-Magnetite Composites as Carriers For Guided Bone Regeneration

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Biomimesis and biomorphic transformations: New concepts applied to bone regeneration

Cited by 48 publications

References 58 publications

Biomimetic materials in regenerative medicine

Biomimetic materials in regenerative medicine

Influence of needle-like morphology on the bioactivity of nanocrystalline wollastonite &ndash; an in vitro study

Porous Hydroxyapatite-Magnetite Composites as Carriers For Guided Bone Regeneration

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Influence of needle-like morphology on the bioactivity of nanocrystalline wollastonite – an in vitro study