Biometric assessments of the posterior fossa by fetal <scp>MRI</scp>: A systematic review

McKinnon, Karen; Kendall, G M; Tann, Cally J; Dyet, Leigh; Sokolska, Magdalena; Baruteau, Kelly Pegoretti; Marlow, Neil; Robertson, Nicola J.; Peebles, Donald; Srinivasan, Latha

doi:10.1002/pd.5874

Cited by 3 publications

(3 citation statements)

References 85 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In clinical practice, fetal brain MRI biometry is performed on series of two-dimensional (2D) 3-to 4-mm-thick slices acquired in three orthogonal planes by T2-weighted sequences (T2WSs). These T2WS-based measurements are then compared to reference values (4,(12)(13)(14)(15). In two large-scale studies, a good inter-rater agreement on T2WS was found for most brain biometric measurements (4,16).…”

Section: Introductionmentioning

confidence: 99%

Fetal Brain Biometric Measurements on 3D Super-Resolution Reconstructed T2-Weighted MRI: An Intra- and Inter-observer Agreement Study

et al. 2021

View full text Add to dashboard Cite

We present the comparison of two-dimensional (2D) fetal brain biometry on magnetic resonance (MR) images using orthogonal 2D T2-weighted sequences (T2WSs) vs. one 3D super-resolution (SR) reconstructed volume and evaluation of the level of confidence and concordance between an experienced pediatric radiologist (obs1) and a junior radiologist (obs2). Twenty-five normal fetal brain MRI scans (18–34 weeks of gestation) including orthogonal 3-mm-thick T2WSs were analyzed retrospectively. One 3D SR volume was reconstructed per subject based on multiple series of T2WSs. The two observers performed 11 2D biometric measurements (specifying their level of confidence) on T2WS and SR volumes. Measurements were compared using the paired Wilcoxon rank sum test between observers for each dataset (T2WS and SR) and between T2WS and SR for each observer. Bland–Altman plots were used to assess the agreement between each pair of measurements. Measurements were made with low confidence in three subjects by obs1 and in 11 subjects by obs2 (mostly concerning the length of the corpus callosum on T2WS). Inter-rater intra-dataset comparisons showed no significant difference (p > 0.05), except for brain axial biparietal diameter (BIP) on T2WS and for brain and skull coronal BIP and coronal transverse cerebellar diameter (DTC) on SR. None of them remained significant after correction for multiple comparisons. Inter-dataset intra-rater comparisons showed statistical differences in brain axial and coronal BIP for both observers, skull coronal BIP for obs1, and axial and coronal DTC for obs2. After correction for multiple comparisons, only axial brain BIP remained significantly different, but differences were small (2.95 ± 1.73 mm). SR allows similar fetal brain biometry as compared to using the conventional T2WS while improving the level of confidence in the measurements and using a single reconstructed volume.

show abstract

Section: Introductionmentioning

confidence: 99%

Fetal Brain Biometric Measurements on 3D Super-Resolution Reconstructed T2-Weighted MRI: An Intra- and Inter-observer Agreement Study

et al. 2021

View full text Add to dashboard Cite

show abstract

“…On the other hand, the stability of the BV angle along pregnancy allows its comparison between anomalies without the interference of the gestational age. McKinnon et al ( 14 ) found similarly, that the tegmento-vermian angle measured by MRI remains unchanged with gestational age, whereas measurements of the tentorial angle are correlated with gestational age.…”

Section: Discussionmentioning

confidence: 90%

“…Other measurements have been previously described to objectively assess the PFFC by fetal MRI ( 15 – 17 ). Mckinnon et al ( 14 ) have reviewed all these measurements in a systematic review published in 2020, identifying those that could be useful in the assessment of PFFC. Despite all the previous publications, we propose two easy and reproducible measurements to calculate the brainstem-tentorium angle, (BT1 and BT2 angles), that could be used, not only in MRI, but also in ultrasound.…”

Section: Discussionmentioning

confidence: 99%

The Brainstem-Vermis and Brainstem-Tentorium Angles in the Fetus: A Study of Their Reproducibility by Fetal Magnetic Resonance Imaging and Their Evolution Along the Gestation

et al. 2022

View full text Add to dashboard Cite

AimTo assess the reproducibility of brainstem-vermis (BV) and brainstem-tentorium (BT) angles measured by fetal Magnetic Resonance Imaging (MRI) during second half of pregnancy in normal and abnormal fetuses. Secondly, to assess reproducibility of two alternative methodologies to measure the brainstem-tentorium angle (BT1 and BT2) proposed by our group that could be more reliable in fetuses with posterior fossa fluid collection (PFFC) anomalies. Finally, to describe the evolution of BV and BT angles along gestation in normal fetuses.MethodsWe conducted a cross-sectional study of BV and BT angles obtained by MRI performed at our center, in 22 fetuses with PFFC and 8 fetuses without PFFC to calculate both angles’ reproducibility and the correlation between them and the gestational age.ResultsWe found good interobserver reproducibility for the BV, BT1 and BT2 angles (Intraclass correlation coefficient: 0.98; 0.89 and 0.88 for each of these angles, with p < 0.001). In patients with PFFC the BT angle could not always be measured. BT angle presented a positive relationship with gestational age (p = 0.002) but BV angle stayed stable. The measurements of BV, BT1, and BT2 angles can be reliably performed by MRI with good interobserver reproducibility.ConclusionBV angle stays stable during pregnancy, whereas BT angle tends to augment with gestational age.

show abstract

Biometry and volumetry in multi-centric fetal brain MRI: assessing the bias of super-resolution reconstruction

Sanchez,

Mihailov,

Koob

et al. 2024

Preprint

View full text Add to dashboard Cite

BackgroundSuper-resolution reconstruction (SRR) of fetal brain magnetic resonance imaging has the potential to enable the development of new imaging biomarkers to better studyin uteroneurodevelopment. However, potential biases in 2D biometric and 3D volumetric measurements due to different SRR techniques remain understudied.PurposeTo assess the consistency of biometric and volumetric measurements across three hospitals using three widely used SRR pipelines.Materials and MethodsThis retrospective study used T2-weighted (T2w) fetal brain MRI scans acquired in routine clinical practice at three hospitals. MRIs from each subject were reconstructed with each of the 3 SRR methods. Four experts did biometric measurements on each SRR volume blinded to the method used. Automated 3D volumetry was performed using a state-of-the-art segmentation method. A univariate analysis was first carried out with Friedman tests with post-hoc Wilcoxon rank-sum tests, and results were confirmed in a multivariate analysis accounting for the effect of gestational age and different raters, using a t-distributed generalized additive model. An additional qualitative evaluation was performed to assess how likely clinicians would be to use the current SRR volumes in their practice, and whether they would prefer it to low-resolution T2w acquisitions. Differences were assessed with Friedman tests and post-hoc Wilcoxon rank-sum tests.Results84 healthy subjects were included in three gestational age groups ([21-28): 25.4±1.9, [28-32): 29.3±1.3, [32-36): 33.5±1.2). Statistically significant differences in biometric measurements were found, but consistently remained below voxel width (0.8 mm). Automated 3D volumetry revealed systematic but very small effects (<2.8%). The qualitative evaluation showed systematic differences between SRR methods for the perception of white matter intensity (p=0.02) and sharpness of the image (p=0.01).ConclusionVariations in 2D and 3D quantitative measurements did not show any large systematic bias when using different SRR methods for radiological assessment in clinical routine across multiple centers, scanners, and raters.SummaryDifferent super-resolution reconstruction methods for fetal brain MRI volumes lead to negligible variations in 2D or 3D quantitative measurements; this may help achieve larger sample sizes in prenatal development studies.Key Results-In this multi-centric retrospective study, 252 super-resolution reconstructions (SRR) scans from 84 healthy subjects showed negligible variations in 2D in biometric measures (below the voxel with of 0.8 mm; p<0.001).-3D measurements revealed small variations ranging from 0.8 % in supratentorial tissues (p<0.001) to 2.8% in the extra-cerebral cerebrospinal fluid (p<0.001).-Clinicians favored having both low resolution and SRR volumes available.

show abstract

Biometric assessments of the posterior fossa by fetal MRI: A systematic review

Cited by 3 publications

References 85 publications

Fetal Brain Biometric Measurements on 3D Super-Resolution Reconstructed T2-Weighted MRI: An Intra- and Inter-observer Agreement Study

Fetal Brain Biometric Measurements on 3D Super-Resolution Reconstructed T2-Weighted MRI: An Intra- and Inter-observer Agreement Study

The Brainstem-Vermis and Brainstem-Tentorium Angles in the Fetus: A Study of Their Reproducibility by Fetal Magnetic Resonance Imaging and Their Evolution Along the Gestation

Biometry and volumetry in multi-centric fetal brain MRI: assessing the bias of super-resolution reconstruction

Contact Info

Product

Resources

About