Biometric approximation of diaphragmatic contractility during sustained hyperpnea

Kabitz, Hans‐Joachim; Walker, David; Schwoerer, Anja; Schlager, Daniel; Walterspacher, Stephan; Storre, Jan Hendrik; Röecker, Kai; Windisch, Wolfram; Vergès, Samuel; Spengler, Christina M.

doi:10.1016/j.resp.2011.01.011

Cited by 8 publications

(7 citation statements)

References 35 publications

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“…Furthermore, contractile fatigue has been shown previously to develop early during fatiguing hyperpnoea at a comparable ventilatory level (Kabitz et al, 2011;Renggli et al, 2008).…”

Section: Critique Of Methodsmentioning

confidence: 84%

Compartmental chest wall volume changes during volitional normocapnic hyperpnoea

Illi

Hostettler

Mohler

et al. 2011

Respiratory Physiology & Neurobiology

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During increased ventilation, inspiratory rib cage muscles have been suggested to take over part of diaphragmatic work after the diaphragm fatigues. We investigated the extent to which this proposed change in muscle recruitment is associated with changes in the relative contribution of chest wall compartments to tidal volume (V(T)). Thirteen healthy subjects performed 1 h of fatiguing normocapnic hyperpnoea. Chest wall volumes were assessed by optoelectronic plethysmography. While breathing frequency increased (43±3 to 56±5 breaths min(-1), p=0.006) and V(T) decreased during normocapnic hyperpnoea (2.6±0.2 to 1.9±0.1l, p<0.001), the relative contribution of chest wall compartments to V(T) remained unchanged (pulmonary rib cage: 48±9 versus 51±14%; abdominal rib cage: 24±4 versus 23±9%; abdomen: 28±8 versus 26±9%; all p>0.05). In conclusion, fatiguing respiratory work is not associated with a change in compartmental contribution to V(T), even in the presence of a change in breathing pattern. AbstractDuring increased ventilation, inspiratory rib cage muscles have been suggested to take over part of diaphragmatic work after the diaphragm fatigues. We investigated the extent to which this proposed change in muscle recruitment is associated with changes in the relative contribution of chest wall compartments to tidal volume (V T ). Thirteen healthy subjects performed 1 h of fatiguing normocapnic hyperpnoea. Chest wall volumes were assessed by optoelectronic plethysmography. While breathing frequency increased (43 ± 3 to 56 ± 5 breaths·min -1 , p = 0.006) and V T decreased during normocapnic hyperpnoea (2.6 ± 0.2 to 1.9 ± 0.1 l, p < 0.001), the relative contribution of chest wall compartments to V T remained unchanged (pulmonary rib cage: 48 ± 9 versus 51 ± 14%; abdominal rib cage: 24 ± 4 versus 23 ± 9%; abdomen: 28 ± 8 versus 26 ± 9%; all p > 0.05). In conclusion, fatiguing respiratory work is not associated with a change in compartmental contribution to V T , even in the presence of a change in breathing pattern.

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“…Furthermore, contractile fatigue has been shown previously to develop early during fatiguing hyperpnoea at a comparable ventilatory level (Kabitz et al, 2011;Renggli et al, 2008).…”

Section: Critique Of Methodsmentioning

confidence: 84%

Compartmental chest wall volume changes during volitional normocapnic hyperpnoea

Illi

Hostettler

Mohler

et al. 2011

Respiratory Physiology & Neurobiology

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“…Johnson and coauthors (27) suggest that DF occurrence and its magnitude are intrinsically related to exercise intensity, whereas others suggest that diaphragmatic strength increases throughout exercise, and fatigue only takes place after exercise cessation (28). Finally, there is evidence suggesting that DF occurs relatively early during high-intensity exercise with no further decrease in contractile force as exercise continues toward exhaustion (46), a notion that has been replicated by the same group during voluntary isocapnic hyperpnea (31,38). Importantly, the aforementioned studies present methodological considerations and limitations that must be acknowledged.…”

Section: Introductionmentioning

confidence: 99%

Temporal characteristics of exercise-induced diaphragmatic fatigue

Archiza

Welch

Geary

et al. 2018

Journal of Applied Physiology

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There is evidence suggesting diaphragmatic fatigue (DF) occurs relatively early during high-intensity exercise; however, studies investigating the temporal characteristics of exercise-induced DF are limited by incongruent methodology. Eight healthy adult males (25 ± 5 yr) performed a maximal incremental exercise test on a cycle ergometer on day 1. A constant-load time-to-exhaustion (TTE) exercise test was conducted on day 2 at 60% delta between the calculated gas exchange threshold and peak work rate. Two additional constant-load exercise tests were performed at the same intensity on days 3 and 4 in a random order to either 50 or 75% TTE. DF was assessed on days 2, 3, and 4 by measuring transdiaphragmatic twitch pressure (P) in response to cervical magnetic stimulation. DF was present after 75 and 100% TTE (≥20% decrease in P). The magnitude of fatigue was 15.5 ± 5.7%, 23.6 ± 6.4%, and 35.0 ± 12.1% at 50, 75, and 100% TTE, respectively. Significant differences were found between 100 to 75 and 50% TTE (both P < 0.01), and 75 to 50% TTE ( P < 0.01). There was a significant relationship between the magnitude of fatigue and cumulative diaphragm force output ( r = 0.785; P < 0.001). Ventilation, the mechanical work of breathing (WOB), and pressure-time products were not different between trials ( P > 0.05). Our data indicate that exercise-induced DF presents a relatively late onset and is proportional to the cumulative WOB; thus the ability of the diaphragm to generate pressure progressively declines throughout exercise. NEW & NOTEWORTHY The notion that diaphragmatic fatigue (DF) occurs relatively early during exercise is equivocal. Our results indicate that DF occurs during high-intensity endurance exercise in healthy men and its magnitude is strongly related to the amount of pressure and work generated by respiratory muscles. Thus we conclude that the work of breathing is the major determinant of exercise-induced DF.

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“…Although MF of inspiratory rib cage muscles decreased exponentially during the NH protocol, it did not reach the lower limit used to characterize fatigue (60%). Many studies assessing the development of inspiratory muscle fatigue during NH protocol analyzed diaphragm fatigue using invasive techniques [ 1 , 29 , 53 , 54 ]. Renggli et al performed an NH protocol in healthy individuals and observed fatigue in the diaphragm and rectus abdominis before task failure.…”

Section: Discussionmentioning

confidence: 99%

“…Normocapnic hyperpnea (NH) and inspiratory pressure threshold loading (IPTL) are respiratory endurance tests (RET) used to assess respiratory muscle function. NH is performed under low resistance and high flow conditions and involves expiratory and inspiratory muscles, whereas IPTL is performed in high resistance and low flow conditions and involves inspiratory muscles [ 1 ]. These two methods may interfere differently with fatigue resistance, leading to distinct physiological responses [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Non-invasive assessment of fatigue and recovery of inspiratory rib cage muscles during endurance test in healthy individuals

et al. 2022

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Introduction Fatigue is defined as loss of capacity to develop muscle force and/or velocity that is reversible at rest. We assessed non-invasively the fatigue and recovery of inspiratory rib cage muscles during two respiratory endurance tests in healthy individuals. Methods The sniff nasal inspiratory pressure (SNIP) was assessed before and after two respiratory endurance tests: normocapnic hyperpnea (NH) and inspiratory pressure threshold loading (IPTL). Contractile (maximum rate of pressure development and time to peak pressure) and relaxation parameters (maximum relaxation rate [MRR], time constant of pressure decay [τ], and half relaxation time) obtained from sniff curves and shortening velocity and mechanical power estimated using optoelectronic plethysmography were analyzed during SNIP maneuvers. Respiratory muscle activity (electromyography) and tissue oxygenation (near-infrared spectroscopy—NIRS) were obtained during endurance tests and SNIP maneuvers. Fatigue development of inspiratory rib cage muscles was assessed according to the slope of decay of median frequency. Results Peak pressure during SNIP decreased after both protocols (p <0.05). MRR, shortening velocity, and mechanical power decreased (p <0.05), whereas τ increased after IPTL (p <0.05). The median frequency of inspiratory rib cage muscles (i.e., sum of sternocleidomastoid, scalene, and parasternal) decreased linearly during IPTL and exponentially during NH, mainly due to the sternocleidomastoid. Conclusion Fatigue development behaved differently between protocols and relaxation properties (MRR and τ), shortening velocity, and mechanical power changed only in the IPTL.

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Biometric approximation of diaphragmatic contractility during sustained hyperpnea

Cited by 8 publications

References 35 publications

Compartmental chest wall volume changes during volitional normocapnic hyperpnoea

Compartmental chest wall volume changes during volitional normocapnic hyperpnoea

Temporal characteristics of exercise-induced diaphragmatic fatigue

Non-invasive assessment of fatigue and recovery of inspiratory rib cage muscles during endurance test in healthy individuals

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