Biometric Analysis of <i>Hunteria umbellata</i> (K.Schum.) Hallier f and Metformin in the treatment of diabetes

Abstract

ABSTRACT:Diabetes is a disease of genetic and environmental origin. It affects the glucose-insulin endocrine metabolic regulatory system due to the malfunction of the insulin producing cells of the pancreas. The purpose of this study is to carry out a comparative analysis of the potencies of hunteria umbellata and metformin on Type 1 diabetes mellitus using bio-statistical analysis. The period of attaining normal blood glucose level across times was taken into consideration as a basis for comparing the efficacy of the oral antidiabetic herbal drug to that of the orthodox antidiabetic drug. The biometric analysis of data from five diabetic patients that were placed on herbal treatment were taken daily for a period of 3 weeks during which they attained normal fasting blood glucose level of between 70mg and 100mg as compared with a recovery period of 8 weeks for the 15 patients treated with metformin 500mg. These results showed that hunteria umbellata is more efficacious in the treatment of diabetes mellitus than metformin 500mg.

The ameliorative potential of aqueous extract of <i>Hunteria unbellata</i> on alloxan—induced diabetes and hyperlipidemia in Wistar rats

“…The results from this study conform to results obtained by Aguwamba, (2022) and Oboh et al (2019). Furthermore, Ajibola et al (2018) also experimented and got similar results. The renal modulating potential may have been due to Phenols found in this plant as this is known to improve renal function (Ganesan et al, 2018).…”

Ethno-medicinal, phytochemistry, and pharmacological importance of Hunteria umbellate (K. Schum.) Hallier f. (Apocynaceae): a useful medicinal plant of sub-Saharan Africa

“…Data interpretation from the study concluded that metformin cures diabetes mellitus in 8 weeks, while H. umbellate aqueous seed extract attains a more effective result in about 3 weeks. Biometric analysis of the study concluded that the extract was better than metformin by a factor of 2.67 [83].…”

Antidiabetic and wound healing potential of biologically fabricated chitosan nanoparticles of aqueous seed extract of Hunteria umbellata

“…The hypoglycemic effect of the seed extract of HU has been documented in normal, high glucose, and nicotinic-induced hyperglycemic rats [50]. When compared to metformin, Ajibola et al [13] found that aqueous seed extract of HU reduced fasting blood glucose in type 2 diabetes patients in just a few weeks, with fewer side effects.…”

“…Oral toxicity studies on experimental animals have validated its safety [12]. However, there has been a report of frequent vomiting caused by an allergic reaction to the extreme bitterness of its seed extract [13]. More so, the bioactive molecules abundant in plants are usually unstable in the gastro intestinal tract due to elevated pH and harsh conditions that render them less effective.…”