Biomethodology and Surgical Techniques

Cunliffe-Beamer, Terrie L.

doi:10.1016/b978-0-12-262503-9.50025-6

Cited by 22 publications

(11 citation statements)

References 159 publications

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“…Ten females and 10 males from each strain were anesthetized with tribomoethanol (Cunliffe-Beamer, 1983) and perfused with phosphatebuffered formalin by an intracardiac perfusion protocol (Dr. D. Wahlsten, University of Alberta, Edmonton, personal communication). The brains were removed and left in buffered formalin for at least 1 week.…”

Section: Methodsmentioning

confidence: 99%

The degree of lateralization of paw usage (handedness) in the mouse is defined by three major phenotypes

Biddle

Eales

1996

Behav Genet

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Lateralization of paw usage in the laboratory mouse may be a useful model system in which to assess the genetic and developmental cause of asymmetry of hand usage. With a set number of paw reaches from a centrally placed food tube, individual mice from an inbred strain will exhibit a reliable number of left and right paw reaches. For a single inbred strain, there are approximately equal numbers of left-pawed and right-pawed mice, but strain differences have been reported in the degree of lateralization of paw preference. We reported a preliminary strain survey in which the strains appeared to fall into two groups of highly lateralized and weakly lateralized paw preference (Biddle et al., 1993). We review here our expanded survey of genetically different strains and stocks of the laboratory mouse, including different species and subspecies. The major genetic trait is the degree of lateralization of paw preference and the strain differences appear to fall into three major classes of highly lateralized, weakly lateralized, and ambilateral preference. The trait exhibits both additivity and dominance in preliminary reciprocal crosses, depending on which strain pairs are used. The wide difference between strains that have highly lateralized and ambilateral paw preference suggests specific genetic tools that could be used to begin a genetic dissection of the causes of this trait. Preliminary assessment of the size of the corpus callosum in three strains with significantly different degrees of lateralization suggests that genetically determined deficiencies and absence of this structure are not the direct cause of the strain differences in the trait of degree of lateralization. In the expanded survey, some strains appear to exhibit a directional deviation from equal numbers of mice with left and right paw usage. Therefore, direction of paw usage may not be a genetically neutral trait, but replicate assessments and genetic tests are needed to confirm this.

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Section: Methodsmentioning

confidence: 99%

The degree of lateralization of paw usage (handedness) in the mouse is defined by three major phenotypes

Biddle

Eales

1996

Behav Genet

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“…The first sample was used for cell counting and the second for flow cytometry. Immediately after collection, the cut surface of the tail was cauterized with styptic powder (Kwik-stop, ARC Laboratories, Atlanta, GA) [12].…”

Section: Blood Collectionmentioning

confidence: 99%

Differences in normal values for murine white blood cell counts and other hematological parameters based on sampling site

et al. 2001

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“…They had free access to food and distilled water. They were fed a regular chow diet (Purina Lab rodent chow 5001; Ralston Purina Co., St. Louis, MO) or a high fat, high cholesterol diet (15% fat, 1 NFR-CETP mice were anesthetized with 2.5% Avertin (Aldrich Chemical Co., Milwaukee, WI) intraperitoneally as described (21) and adrenalectomized by a standard procedure (22). Sham-operated animals were subjected to the same surgical manipulation except the adrenal glands were not removed.…”

Section: Methodsmentioning

confidence: 99%

Decreased cholesteryl ester transfer protein (CETP) mRNA and protein and increased high density lipoprotein following lipopolysaccharide administration in human CETP transgenic mice.

Masucci-Magoulas

Moulin²,

Jiang³

et al. 1995

J. Clin. Invest.

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IntroductionThe plasma cholesteryl ester transfer protein (CETP) mediates the exchange of HDL cholesteryl esters (CE) The metabolism of HDL is regulated, in part, by the activities of lipases and lipid transfer proteins (1). Cholesteryl esters, generated in HDL by lecithin:cholesterol acyltransferase, are exchanged with triglycerides of VLDL, as a result of the activity of cholesteryl ester transfer protein (CETP)'. The subsequent activity of hepatic lipase on triglyceride-enriched HDL results in a decrease in HDL size and catabolism of the major apoliprotein of HDL, apoA-I (2). In a striking demonstration of the interaction of hypertriglyceridemia with cholesteryl ester transfer processes, hypertriglyceridemic apoC-II transgenic mice show profound reductions in HDL cholesterol and apoA-I when crossed with human CETP/apoA-I transgenic mice, to produce apoA-I/CETP/apoC-llH transgenic mice (3). In addition to plasma triglyceride concentration, effective plasma CETP activity is also influenced by changes in CETP concentration, such as those resulting from changes in dietary cholesterol or probucol therapy (4, 5).HDL is thought to mediate the reverse transport of cholesterol from peripheral tissues to the liver (6). In addition to this well-known role, Ulevitch et al. (7) have suggested another, novel function for HDL, namely to bind bacterial lipopolysaccharide (endotoxin) and thereby to modulate its biological effects. The binding of endotoxin to HDL can prevent endotoxininduced death (8). Harris et al. (9) have shown that VLDL and chylomicrons can also bind endotoxin, and protect mice against endotoxin-induced death. However, the potency of HDL appeared to be greater than that of other lipoproteins (9), and the molar concentrations of HDL in plasma are usually higher than other lipoproteins. Another role of HDL may be to provide cholesterol for adrenal corticosteroid synthesis ( 10-12), a function that could be particularly important during stress (13).The purpose of the present study was to examine the possible regulation of CETP gene expression in response to LPS administration. We suspected that CETP might be altered by LPS, since LPS has profound effects on lipoprotein metabolism and is known to regulate lipoprotein lipase and LCAT activities ( 14,15

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Biomethodology and Surgical Techniques

Cited by 22 publications

References 159 publications

The degree of lateralization of paw usage (handedness) in the mouse is defined by three major phenotypes

The degree of lateralization of paw usage (handedness) in the mouse is defined by three major phenotypes

Differences in normal values for murine white blood cell counts and other hematological parameters based on sampling site

Decreased cholesteryl ester transfer protein (CETP) mRNA and protein and increased high density lipoprotein following lipopolysaccharide administration in human CETP transgenic mice.

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