Biomembranes in bioelectronic sensing

Jayaram, AK; Pappa, Anna‐Maria; Ghosh, Surajit; Manzer, Zachary A.; Traberg, Walther C.; Knowles, Tuomas P. J.; Daniel, Susan; Owens, Róisı́n M.

doi:10.1016/j.tibtech.2021.06.001

Cited by 13 publications

(13 citation statements)

References 119 publications

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“…, 141. , 142. Using this approach, our group developed PIM-containing mycosomes on the surface of SBA15-type mesoporous silica, a biocompatible material, to generate a stable lipid-displaying construct with high loading capabilities, leading to specific interactions with cells from the innate immune system.…”

Section: Current Advances In Nanomedicine To Exploit Mycobacterial Li...mentioning

confidence: 99%

Spotlight on mycobacterial lipid exploitation using nanotechnology for diagnosis, vaccines, and treatments

Valdemar-Aguilar

Manisekaran

Acosta-Torres

et al. 2023

Nanomedicine: Nanotechnology, Biology and Medicine

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Section: Current Advances In Nanomedicine To Exploit Mycobacterial Li...mentioning

confidence: 99%

Spotlight on mycobacterial lipid exploitation using nanotechnology for diagnosis, vaccines, and treatments

Valdemar-Aguilar

Manisekaran

Acosta-Torres

et al. 2023

Nanomedicine: Nanotechnology, Biology and Medicine

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“…specificity to ligands, selective transport, in situ signal amplification, and variable memory) in a form-factor that also assists in device durability. While the integration of these components has been explored for biosensing, [205][206][207][208][209][210][211][212] aiming for neuromorphic functionalities is just beginning. 213 We hypothesize that a hybrid biomembrane-organic electrochemical transistor device can: (1) yield biocompatible neuromorphic devices which present to their surroundings a multifunctional biomimetic interface; and (2) leverage the advantages of each to improve memristive performance and tunability.…”

Section: New Directions For Bio-derived Neuromorphic Materialsmentioning

confidence: 99%

Bioderived materials for stimuli-responsive, adaptive, and neuromorphic systems: A perspective

Makhoul-Mansour

Maraj

Sarles

2022

Journal of Composite Materials

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In this concept article, we review recent works on the use of biologically-derived materials, including biomolecules, hybrid biomolecular composites, and natural tissues for achieving stimuli-responsiveness, adaptability, and memory storage for potential neuromorphic computing applications. Unlike solid-state materials, bioderived platforms are often intrinsically modular, including possessing the ability to leverage the diversity of naturally multifunctional biomolecules, cornerstones in biological transduction, signaling, and learning. The primary neuromorphic functionality of bioderived systems considered here is memory resistance, as obtained through combinations of resistive switching, activity-dependent plasticity, and memory storage. In some cases, these capabilities are achieved in bio-derived systems by closely emulating the structure, function, or signaling mechanisms found in living neurons. Our review considers bioderived systems that span multiple length scales and levels of hierarchical complexity: from single-molecule enabled devices to intact tissues, interrogated either in vitro or in vivo on living organisms. Through this exercise, we offer our perspective on research opportunities in the development and use of synapse- and neuron-inspired bioderived systems, including the prospect of biocompatible, and even tissue-like, neuromorphic materials to smartly monitor and treat injury and disease, deliver therapeutics, and interpret neural activity. These capabilities could unlock a new generation of smart, adaptable bioderived composites that autonomously report, learn (i.e., classify, forecast), compute, and actuate in the direct vicinity of living cells and tissues, i.e. at the edge of biology.

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“…Supported lipid bilayers (SLB) assembled on the surface of conducting polymers provide a unique solution to couple TMP activity with electronic interfaces. 7 SLBs are planar, supported membranes that are compatible with various surface analytical techniques. 8−11 Importantly, SLBs can be used to coat electrodes with a lipid membrane to translate biological activity into electrical readouts.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Supported lipid bilayers (SLB) assembled on the surface of conducting polymers provide a unique solution to couple TMP activity with electronic interfaces . SLBs are planar, supported membranes that are compatible with various surface analytical techniques. − Importantly, SLBs can be used to coat electrodes with a lipid membrane to translate biological activity into electrical readouts. ,− While the direct deposition of cell membranes on PEDOT surfaces has provided a promising strategy to interface lipid bilayers and TMPs onto electronically active materials, , biological membranes are highly complex, which can confound measurement signals.…”

Section: Introductionmentioning

confidence: 99%

Cell-Free Synthesis Goes Electric: Dual Optical and Electronic Biosensor via Direct Channel Integration into a Supported Membrane Electrode

et al. 2023

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Assembling transmembrane proteins on organic electronic materials is one promising approach to couple biological functions to electrical readouts. A biosensing device produced in such a way would enable both the monitoring and regulation of physiological processes and the development of new analytical tools to identify drug targets and new protein functionalities. While transmembrane proteins can be interfaced with bioelectronics through supported lipid bilayers (SLBs), incorporating functional and oriented transmembrane proteins into these structures remains challenging. Here, we demonstrate that cell-free expression systems allow for the one-step integration of an ion channel into SLBs assembled on an organic conducting polymer, poly(3,4-ethylenedioxythiophene) polystyrenesulfonate (PEDOT:PSS). Using the large conductance mechanosensitive channel (MscL) as a model ion channel, we demonstrate that MscL adopts the correct orientation, remains mobile in the SLB, and is active on the polyelectrolyte surface using optical and electrical readouts. This work serves as an important illustration of a rapidly assembled bioelectronic platform with a diverse array of downstream applications, including electrochemical sensing, physiological regulation, and screening of transmembrane protein modulators.

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Biomembranes in bioelectronic sensing

Cited by 13 publications

References 119 publications

Spotlight on mycobacterial lipid exploitation using nanotechnology for diagnosis, vaccines, and treatments

Spotlight on mycobacterial lipid exploitation using nanotechnology for diagnosis, vaccines, and treatments

Bioderived materials for stimuli-responsive, adaptive, and neuromorphic systems: A perspective

Cell-Free Synthesis Goes Electric: Dual Optical and Electronic Biosensor via Direct Channel Integration into a Supported Membrane Electrode

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