Biomedicine: Programmable and Multifunctional DNA‐Based Materials for Biomedical Applications (Adv. Mater. 24/2018)

Zhang, Yuezhou; Tu, Jing; Wang, Dongqing; Zhu, Haitao; Maity, Sajal Kumar; Qu, Xiangmeng; Bogaert, Bram; Pei, Hao

doi:10.1002/adma.201870176

Cited by 23 publications

(25 citation statements)

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“…The nanostructure has been developed with numerous potential applications in molecular biology and nanotechnology. − However, traditional DNA nanostructure can be stable only at low temperature with Mg 2+ because of it being assembled by hydrogen bonding of the Watson–Crick base-pairing rather than the covalent bond. − , Those limit DNA nanostructures from being widely utilized, especially on clinical practice. The DNA nanomesh has the ability to enrich specific DNA or protein molecules.…”

Section: Resultsmentioning

confidence: 99%

Novel Stable DNA Nanoscale Material and Its Application on Specific Enrichment of DNA

Wang

Lan

et al. 2020

ACS Appl. Mater. Interfaces

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DNA nanostructures are a new type of technology for constructing nanomaterials that has been developed in recent years. By relying on the complementary pairing of DNA molecules to form a double-stranded property, DNA molecules can construct a variety of nanoscale structures of 2D and 3D shapes. However, most of the previously reported DNA nanostructures rely solely on hydrogen bonds to maintain structural stability, resulting in DNA structures that can be maintained only at low temperature and in the presence of Mg 2+ , which greatly limits the application of DNA nanostructures. This study designed a DNA nanonetwork structure (nanonet) and changed its topological structure to DNA nanomesh by using DNA topoisomerase to make it thermally stable, while escaping the dependence on Mg 2+ , and the stability of the structure can be maintained in a nonsolution state. Moreover, the nanomesh also has a large amount of ssDNA (about 50%), providing active sites capable of exerting biological functions. Using the above characteristics, we prepared the nanomesh into a device capable of adsorbing specific DNA molecules, and used the device to enrich DNA. We also tried to mount antibodies using DNA probes. Preliminary results show that the DNA nanomesh also has the ability to enrich specific proteins.

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Section: Resultsmentioning

confidence: 99%

Novel Stable DNA Nanoscale Material and Its Application on Specific Enrichment of DNA

Wang

Lan

et al. 2020

ACS Appl. Mater. Interfaces

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“…Recently, controlled arrangements of nucleic acids into specific nanoarchitectures can assign unusual properties and found themselves braoder biomedical applications, [ 238 ] drug delivery in particular. [ 239 ] It is thought that the co‐delivery of nucleic acids and small chemodrugs allow readily access to gene and protein targets; spherical nucleic acids (SNAs) rapid endocytosis makes them suitable for drug delivery to overcome anticancer drug resistance.…”

Section: Biomacromolecule‐drug Conjugatesmentioning

confidence: 99%

Nanoparticulation of Prodrug into Medicines for Cancer Therapy

et al. 2021

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This article provides a broad spectrum about the nanoprodrug fabrication advances co-driven by prodrug and nanotechnology development to potentiate cancer treatment. The nanoprodrug inherits the features of both prodrug concept and nanomedicine know-how, attempts to solve underexploited challenge in cancer treatment cooperatively. Prodrugs can release bioactive drugs on-demand at specific sites to reduce systemic toxicity, this is done by using the special properties of the tumor microenvironment, such as pH value, glutathione concentration, and specific overexpressed enzymes; or by using exogenous stimulation, such as light, heat, and ultrasound. The nanotechnology, manipulating the matter within nanoscale, has high relevance to certain biological conditions, and has been widely utilized in cancer therapy. Together, the marriage of prodrug strategy which shield the side effects of parent drug and nanotechnology with pinpoint delivery capability has conceived highly camouflaged Trojan horse to maneuver cancerous threats.

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“…Functional and biological targeting DNA entities like aptamers, 54 DNAzymes, 41 DNA-based nanomachines, 55 and nanosensors 56 have been widely explored in the development of smart DNA materials for targeted applications. 24,57 The recognition of analytes by these surface entities on hydrogels induces changes in physiochemical characteristics, namely, cross-linking density, volume, mechanical, optical, and other properties. Further, these changes can be transformed into a detection signal for the release of a particular drug or its sensing for therapeutic purposes.…”

Section: Dna-based Hydrogelsmentioning

confidence: 99%

Functional DNA Based Hydrogels: Development, Properties and Biological Applications

Morya

Walia

Mandal

et al. 2020

ACS Biomater. Sci. Eng.

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DNA-based nanostructures have emerged as a versatile component for nanoscale construction of soft materials. Multiple structural, functional properties and versatility in conjugation with other biomolecules made DNA the material of choice to use in various biomedical applications. DNA-based hydrogels significantly attracted attention in recent years owing to their properties and applications in biosensing, bioimaging, and therapeutics. Here, we summarize the recent advances in the area of DNA hydrogels where these are used either as structural material or as functional entities to make hybrid constructs with various biomedical applications. Multiple synthetic routes for constructing DNA hydrogels are summarized first, where the structural motifs and spatial arrangements are considered for the classification of DNA materials. We then present the characterization and properties of DNA hydrogels using multiple imaging and biophysical techniques. Further, different biomedical applications of DNA hydrogels are presented such as biosensing, bioimaging, and targeted drug delivery and as scaffolds to program cellular systems. Last, we discuss the vision and potential of DNA based hydrogels as an emerging class of therapeutically important devices for theragnostic and other biological applications.

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Biomedicine: Programmable and Multifunctional DNA‐Based Materials for Biomedical Applications (Adv. Mater. 24/2018)

Cited by 23 publications

References 0 publications

Novel Stable DNA Nanoscale Material and Its Application on Specific Enrichment of DNA

Novel Stable DNA Nanoscale Material and Its Application on Specific Enrichment of DNA

Nanoparticulation of Prodrug into Medicines for Cancer Therapy

Functional DNA Based Hydrogels: Development, Properties and Biological Applications

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