Biomedical Significance of Tryptamine: A Review

Kousara, Shazia; Anjuma, Sadia Noreen; Jaleel, Farrukh; Khana, Jallat; Naseema, Sidra

doi:10.4172/2329-6887.1000239

Cited by 29 publications

(20 citation statements)

References 45 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These are also used for migraine treatment, suppression of nausea and vomiting caused by cancer chemotherapy and radiotherapy, treatment of irritable bowel syndrome, and control of the diurnal rhythm of various physiological functions. [ 4,5 ] Tryptamine‐type ligands, one of the oldest classes of ligands in coordination chemistry, have been used extensively on complex transition and main group metals. [ 6 ] The azomethine group of Schiff's base plays an important role in excellent antibacterial, antifungal, anticancer, antidiabetic, and anti‐inflammatory activities.…”

Section: Introductionmentioning

confidence: 99%

Preparation, spectroscopic study of Schiff base derived from dopamine and metal Ni(II), Pd(II), and Pt(IV) complexes, and activity determination as antioxidants

Kareem

Al‐Hamdani

Jirjees

et al. 2020

J of Physical Organic Chem

View full text Add to dashboard Cite

A new Schiff base (HL2) ligand (4‐{2‐[(2‐hydroxy‐benzylidene)‐amino]‐ethyl}‐benzene‐1,2‐diol) has been synthesized by condensing of 4‐(2‐amino‐ethyl)‐benzene‐1,2‐diol and 2‐hydroxy‐benzaldehyde. In turn, its transition metal complexes were prepared, having the following general formulas: Ni(L2)2, Pd(L2)2, and Pt(L2)22Cl. The prepared ligand and its metal complexes Ni(II), Pd(II), and Pt(IV) have been characterized by Fourier transform infrared (FTIR) spectra, proton nuclear magnetic resonance (1H‐NMR) elemental analysis, metal content, chloride content, molar conductance, ultraviolet–visible (UV–Vis) spectra, magnetic susceptibility, mass spectrometry (MS) spectra, and thermogravimetric analysis (TGA). The consequences proposed that Schiff base acts like a bidentate ligand for all the prepared complexes. The antioxidant performance of as‐prepared compounds was inspected using the DPPH radical scavenging method. The compounds showed antioxidant activities of scavenging free radicals.

show abstract

Section: Introductionmentioning

confidence: 99%

Preparation, spectroscopic study of Schiff base derived from dopamine and metal Ni(II), Pd(II), and Pt(IV) complexes, and activity determination as antioxidants

Kareem

Al‐Hamdani

Jirjees

et al. 2020

J of Physical Organic Chem

View full text Add to dashboard Cite

show abstract

“…Similar to AeD7L1, AlboD7L1 had the highest affinity to biogenic amine (serotonin and norepinephrine). Serotonin, norepinephrine, epinephrine, and tryptamine stimulate vasoconstriction and reduce the blood flow to the injury site [ 15 , 50 ]. We detected binding to tryptamine, a natural vasoconstrictor similar to serotonin [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

“…Serotonin, norepinephrine, epinephrine, and tryptamine stimulate vasoconstriction and reduce the blood flow to the injury site [ 15 , 50 ]. We detected binding to tryptamine, a natural vasoconstrictor similar to serotonin [ 50 ]. This is the first time tryptamine binding is tested with a D7 protein.…”

Section: Discussionmentioning

confidence: 99%

Aedes albopictus D7 Salivary Protein Prevents Host Hemostasis and Inflammation

et al. 2020

View full text Add to dashboard Cite

Mosquitoes inject saliva into the host skin to facilitate blood meal acquisition through active compounds that prevent hemostasis. D7 proteins are among the most abundant components of the mosquito saliva and act as scavengers of biogenic amines and eicosanoids. Several members of the D7 family have been characterized at the biochemical level; however, none have been studied thus far in Aedes albopictus, a permissive vector for several arboviruses that causes extensive human morbidity and mortality. Here, we report the binding capabilities of a D7 long form protein from Ae. albopictus (AlboD7L1) by isothermal titration calorimetry and compared its model structure with previously solved D7 structures. The physiological function of AlboD7L1 was demonstrated by ex vivo platelet aggregation and in vivo leukocyte recruitment experiments. AlboD7L1 binds host hemostasis agonists, including biogenic amines, leukotrienes, and the thromboxane A2 analog U-46619. AlboD7L1 protein model predicts binding of biolipids through its N-terminal domain, while the C-terminal domain binds biogenic amines. We demonstrated the biological function of AlboD7L1 as an inhibitor of both platelet aggregation and cell recruitment of neutrophils and eosinophils. Altogether, this study reinforces the physiological relevance of the D7 salivary proteins as anti-hemostatic and anti-inflammatory molecules that help blood feeding in mosquitoes.

show abstract

“…Tryptamine, which is found in fungi, plants, and animals [146] are naturally occurring indole alkaloids that exhibit a broad range of medicinal and biological activities [147]. Thus, α-methyltryptamine may act as an antidepressant, a powerful psychedelic drug, a stimulant, and a monoamine oxidase inhibitor [148]. Similarly, 5-carboxamidotryptamine presents a powerful vasodilator effect [149].…”

Section: Of 35mentioning

confidence: 99%

Ultrasound for Drug Synthesis: A Green Approach

2020

View full text Add to dashboard Cite

This last century, the development of new medicinal molecules represents a real breakthrough in terms of humans and animal life expectancy and quality of life. However, this success is tainted by negative environmental consequences. Indeed, the synthesis of drug candidates requires the use of many chemicals, solvents, and processes that are very hazardous, toxic, energy consuming, expensive, and generates a large amount of waste. Many large pharmaceutical companies have thus moved to using green chemistry practices for drug discovery, development, and manufacturing. One of them is the use of energy-efficient activation techniques, such as ultrasound. This review summarizes the latest most representative works published on the use of ultrasound for sustainable bioactive molecules synthesis.

show abstract

Biomedical Significance of Tryptamine: A Review

Cited by 29 publications

References 45 publications

Preparation, spectroscopic study of Schiff base derived from dopamine and metal Ni(II), Pd(II), and Pt(IV) complexes, and activity determination as antioxidants

Preparation, spectroscopic study of Schiff base derived from dopamine and metal Ni(II), Pd(II), and Pt(IV) complexes, and activity determination as antioxidants

Aedes albopictus D7 Salivary Protein Prevents Host Hemostasis and Inflammation

Ultrasound for Drug Synthesis: A Green Approach

Contact Info

Product

Resources

About