Biomedical significance of endothelial cell specific growth factor, angiopoietin

Koh, Gou Young; Kim, Injune; Kwak, Hee Jin; Yun, Mijin; Leem, Jaechan

doi:10.1038/emm.2002.1

Cited by 50 publications

(48 citation statements)

References 2 publications

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“…The decreased ANGPT-2/ANGPT-1 ratio at Day 40 of early pregnancy in the present study indicates consistent stability of blood vessels. Moreover, ANGPT-1 plays a role as a survival factor of endothelial cells [26]. Thus, the increase of ANGPT-1 mRNA indicates that ANGPT-1 may support the maintenance of endothelial cells without vessel stabilization through smooth muscle cells or pericytes in consideration of the fact that less SMA was detected on Day 40.…”

Section: Discussionmentioning

confidence: 98%

Vascular Changes in the Corpus Luteum During Early Pregnancy in the Cow

Beindorff

Nagai

Shirasuna

et al. 2010

Journal of Reproduction and Development

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Abstract. The present study determined vascular changes in the bovine corpus luteum (CL) at Day 16 (early maternal recognition period) and Day 40 in early pregnancy and compared them to the CL from Day 12 and Day 16 of the estrous cycle. The CLs were analyzed in the central and peripheral regions, where site-depending features of vessels and angiogenic factors are evident. The same protein level of the endothelial cell marker von Willebrand factor was retained in the CL from Day 16 of the estrous cycle to Day 40 of early pregnancy. The protein level of pericytes and smooth muscle cells was determined using smooth muscle α-actin; the level decreased at Day 40 of early pregnancy in both regions of the CL. No significant change in the expressions of vascular endothelial growth factors VEGF164 and VEGF120 mRNA occurred from Day 16 of the estrous cycle until Day 40 of early pregnancy. Angiopoietin (ANGPT)-2 / ANGPT-1 mRNA ratio (an index of instability of vasculature) increased in the periphery at Day 16 of the estrous cycle and then decreased until Day 40 of early pregnancy. The results suggest that there is no difference in vascular structure between non-pregnant and pregnant luteal tissue during the early maternal recognition period (Day 16). Also, luteal rescue by early pregnancy may be not associated with further blood vessel formation but rather may be related to the decrease of blood vessels per unit of area and blood vessel stabilization in the bovine CL. he corpus luteum (CL) is temporarily formed in the ovary following ovulation and secretes progesterone (P) to regulate the estrous cycle and to support the establishment of pregnancy. In cows, the CL begins to regress within 17-18 days after ovulation during the estrous cycle but retains a functional lifespan of more than 200 days during pregnancy [1]. Up to 40% of total embryonic loss occurs between Days 7 and 17 of pregnancy [2,3], which is a period associated with inadequate P concentrations. Thus, some changes of function and morphology in the CL to approve conception are critical during the estrous cycle, the early maternal recognition period and early pregnancy in the cow.Several distinct cell types, such as small and large luteal cells, vascular endothelial cells and pericytes, are distributed in the bovine CL [4]. More than 50% of cells in the mature CL are of vascular origin [4]. Alterations in luteal vascularity are associated with the luteinization and formation of the CL [5]. Angiogenesis is critical to development of the CL, as an inadequate microvasculature compromises luteal function [6]. The formation of a dense capillary network in the ovary enables the hormone-producing cells to obtain the oxygen, nutrients and also precursors necessary to synthesize and release different hormones essential for maintenance of the ovarian functions. Large luteal blood vessels, i.e., arteriolovenous vessels, have a smooth muscle cell layer and exist in the peripheral, but not central, region of the rabbit CL [7]. Indeed, in the bovine CL, the arteriolovenous ...

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Section: Discussionmentioning

confidence: 98%

Vascular Changes in the Corpus Luteum During Early Pregnancy in the Cow

Beindorff

Nagai

Shirasuna

et al. 2010

Journal of Reproduction and Development

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“…[3][4][5][6] Angiopoietins and vascular endothelial growth factor (VEGF) are growth factors that have been shown to play an important role in the development, physiology and pathophysiology of endothelial cells. 7 Angiopoietin-1 (Ang-1) activates the endothelial Tie-2 receptor thereby maintaining a quiescent resting state of the endothelium. On the other side, Angiopoietin-2 (Ang-2) binds to the same site of the Tie-2 receptor but functions as an antagonist ligand of Tie-2.…”

Section: Introductionmentioning

confidence: 99%

Angiopoietin-2, Marker and Mediator of Endothelial Activation With Prognostic Significance Early After Trauma?

Ganter¹,

Cohen²,

Brohi³

et al. 2008

Annals of Surgery

113

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“…Gene products that augment O2 supply at the tissue level include erythropoietin (Epo), which increases the proliferation of erythrocytes, tyrosine hydroxylase, which is necessary for the synthesis of the neurotransmitter dopamine in the carotid bodies, and the angiogenic factor VEGF (vascular endothelial cell growth factor), which stimulates growth of new capillaries (Chandel et al, 2000;Koh et al, 2002). Oxygen homeostasis is primarily controlled by a cellular oxygen-sensing transcription factor, hypoxia-induHypoxia activates signal transducers and activators of transcription 5 (STAT5) and increases its binding activity to the GAS elem ent in m am m ary epithelial cells cible factor 1 (HIF-1), which induces the transcription of more than 40 proteins, including VEGF (Choi et al, 2003).…”

Section: Introductionmentioning

confidence: 99%