BIOMedical Search Engine Framework: Lightweight and customized implementation of domain-specific biomedical search engines

Jácome, Alberto G.; Fdez-Riverola, Florentino; Lourenço, Anália

doi:10.1016/j.cmpb.2016.03.030

Cited by 4 publications

(1 citation statement)

References 30 publications

(20 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other tools include Twister that is aimed at reducing the screening time of systematic literature reviews [37]; SWIFT-Review, which is a workbench for systematic review based on NLP [38]; SparkText, which is a big data framework for mining biomedical literature [39]; and GIS, which is an NLP-based framework for gene discovery from scientific literature [40]. In addition to these tools, several frameworks for mining biomedical literature have been developed [41][42][43][44][45][46][47].…”

Section: Exploring Voluminous Informationmentioning

confidence: 99%

DES-ROD: Exploring Literature to Develop New Links between RNA Oxidation and Human Diseases

Essack

Salhi

Neste

et al. 2020

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Normal cellular physiology and biochemical processes require undamaged RNA molecules. However, RNAs are frequently subjected to oxidative damage. Overproduction of reactive oxygen species (ROS) leads to RNA oxidation and disturbs redox (oxidation-reduction reaction) homeostasis. When oxidation damage affects RNA carrying protein-coding information, this may result in the synthesis of aberrant proteins as well as a lower efficiency of translation. Both of these, as well as imbalanced redox homeostasis, may lead to numerous human diseases. The number of studies on the effects of RNA oxidative damage in mammals is increasing by year due to the understanding that this oxidation fundamentally leads to numerous human diseases. To enable researchers in this field to explore information relevant to RNA oxidation and effects on human diseases, we developed DES-ROD, an online knowledgebase that contains processed information from 298,603 relevant documents that consist of PubMed abstracts and PubMed Central full-text articles. The system utilizes concepts/terms from 38 curated thematic dictionaries mapped to the analyzed documents. Researchers can explore enriched concepts, as well as enriched pairs of putatively associated concepts. In this way, one can explore mutual relationships between any combinations of two concepts from used dictionaries. Dictionaries cover a wide range of biomedical topics, such as human genes and proteins, pathways, Gene Ontology categories, mutations, noncoding RNAs, enzymes, toxins, metabolites, and diseases. This makes insights into different facets of the effects of RNA oxidation and the control of this process possible. The usefulness of the DES-ROD system is demonstrated by case studies on some known information, as well as potentially novel information involving RNA oxidation and diseases. DES-ROD is the first knowledgebase based on text and data mining that focused on the exploration of RNA oxidation and human diseases.

show abstract