Biomedical research and capacity building: Bilateral collaboration between research institutes in South Africa and Cameroon

Jacobs, Graeme Brendon; Ikomey, George Mondinde

doi:10.7196/samj.2016.v106i10.11365

Cited by 1 publication

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Ethiopia, from 40 up to 70% of HIV patients also have tuberculosis 11 , 12 . To battle the disease's spread and timeliness, WHO suggests a variety of combined measures for HIV/TB co-infection, such as initiating antiretroviral therapy (ART) to minimize the risk of morbidity and mortality related to HIV, or improving the life quality for HIV-positive peoples 13 . Despite the WHO recommendation that all TB/HIV co-infected patients start ART regardless of their baseline CD4 cell level, Ethiopia's national annual performance report found that ART coverage of patients co-infected with TB and HIV was 70% 14 .…”

Section: Introductionmentioning

confidence: 99%

Survival rate and predictors of mortality among TB/HIV co-infected adult patients: retrospective cohort study

Lelisho

Wotale

Tareke

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Nowadays, Tuberculosis remains the major cause of HIV-associated mortality, which accounts for 1 out of every 5 HIV-related mortality worldwide. This study aimed to determine the survival rate and predictors of mortality among TB/HIV co-infected patients. An institution-based retrospective cohort study was undertaken on adult TB/HIV co-infected individuals between 1st February 2014 and 30th January 2022 at Mettu Karl Referral Hospital. A Cox regression model was used to identify predictors of survival time to death among TB/HIV co-infected patients. This study comprised 402 TB and HIV co-infected adult patients. Among these, 84 (20.9%) died, and 318 (79.1%) were censored. The study subjects have been followed up for 6920 person-months with an overall median survival time of 17.6 months. The overall incidence rate was 12.1 per 1000 person months [95% CI: 9.77–14.98]. The results of a multivariable Cox regression analysis showed that being at an older age, urban residence, WHO clinical stage II & IV, CD4 count of ≥ 200 cells/mm3, bedridden functional status, using INH, and using CPT were associated with the survival time of TB and HIV co-infected patients at a significance level of alpha = 0.05. This retrospective study found that high mortality of TB/HIV co-infected patients occurred in the earlier months of treatment initiation. Close monitoring of patients with low CD4, who do not utilize CPT, who are in advanced WHO stages, and who have poor functional levels can help them improve their health and live longer.

show abstract

Section: Introductionmentioning

confidence: 99%