Biomedical properties of laser prepared silver-doped hydroxyapatite

Jelı́nek, M.; Weiserová, Marie; Kocourek, T.; Zezulová, Marketa; Strnad, Jakub

doi:10.1134/s1054660x11130159

Cited by 19 publications

(18 citation statements)

References 15 publications

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“…Pathogens found at infected oral implant sites, including S. mutans 90) , S. aureus 93,94) , S. oralis 43) , P. gingivalis and A. actinomycetemcomitans 84) were killed or significantly reduced upon contact with silver-implanted surfaces. All tested silver surfaces, such as hydroxyapatite (HA)-silver-surfaces 42,44,[46][47][48][49][50][51]91,161) or plasma sprayed silver-implanted HA 45,95) shared good antimicrobial activity.…”

Section: Silver-implanted Surfacesmentioning

confidence: 99%

Antimicrobial dental implant functionalization strategies —A systematic review

Grischke

Eberhard

Stiesch

2016

Dental Materials Journal

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Section: Silver-implanted Surfacesmentioning

confidence: 99%

Antimicrobial dental implant functionalization strategies —A systematic review

Grischke

Eberhard

Stiesch

2016

Dental Materials Journal

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“…The plates were incubated overnight and the number of growing colonies was counted. The bactericidal efficacy expressing the antibacterial properties of different silver doped films was estimated according the formula [10,11,21]:…”

Section: Methodsmentioning

confidence: 99%

“…1. Since silver is known for its excellent antibacterial properties, its use as a suitable dopant seemed a viable road to take [10][11][12][13][14][15][16][17]. In this contribution the silver doped metallic materials (titanium alloy Ti6Al4V and 316L steel) of various concentrations was created by pulsed laser deposition (PLD) method.…”

Section: Introductionmentioning

confidence: 99%

Silver doped metal layers for medical applications

Kocourek

Jelı́nek

Mikšovský

et al. 2014

J. Phys.: Conf. Ser.

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View the article online for updates and enhancements. Related contentSilver-doped metal layers for medical applications T Kocourek, M Jelínek, J Mikšovský et al. Abstract. Biological, physical and mechanical properties of silver-doped layers of titanium alloy Ti6Al4V and 316L steel prepared by pulsed laser deposition were studied. Metallic silver-doped coatings could be a new route for antibacterial protection in medicine. Thin films of silver and silver-doped materials were synthesized using KrF excimer laser deposition. The materials were ablated from two targets, which were composed either from titanium alloy with silver segments or from steel with silver segments. The concentration of silver ranged from 1.54 at% to 4.32 at% for steel and from 3.04 at% to 13.05 at% for titanium alloy. The layer properties such as silver content, structure, adhesion, surface wettability, and antibacterial efficacy (evaluated by Escherichia coli and Bacillus subtilis bacteria) were measured. Film adhesion was studied using scratch test. The antibacterial efficacy changed with silver doping up to 99.9 %. Our investigation was focused on minimum Ag concentration needed to reach high antibacterial efficiency, high film adhesion, and hardness.

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“…Chromium is also a common part of stainless steels and alloys used for implants (up to 30 wt%) [4]. Chromium-doped diamond-like carbon (DLC) layers were prepared by a hybrid technology using a combination of PLD and magnetron sputtering (2 inch.…”

Section: Cr: Dlc Coating (For Better Adhesion)mentioning

confidence: 99%

Doped and Multilayer Biocompatible Materials Prepared by Hybrid Laser Deposition

Jelı́nek¹,

Kocourek²,

Remsa³

et al. 2018

IJBBB

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Abstract:Hybrid laser technology for synthesizing doped, nanocomposite, single and multilayers of amorphous or nanocrystalline materials are presented. The technique use method of pulsed laser deposition (PLD) or combination of PLD with magnetron sputtering, radiofrequency discharges or two PLD running together. Examples of deposition and study of doped biocompatible materials as Cr: DLC, Ti: DLC, Ag: DLC, Ag: hydroxyapatite, and enhancement of sp3-DLC layers bonds by in situ ion gun bombardment are given.Key words: PLD, hybrid PLD, biocompatible coating, implants. IntroductionBiomaterials, i.e. natural or artificial materials designed for application in biotechnologies and medicine, are widely used for replacing irreversibly damaged tissues in the human body. Biomaterials have to meet the requirements for well-functioning and long-term durability of the implants, namely biocompatibility, good corrosion and fatigue resistance, wear resistance and biomechanical compatibility [1]. In many cases a single coating material alone cannot fulfil the technical requirements. To improve physical, mechanical and biocompatible properties of implant coatings, the layers can be doped (enriched) with other elements.The cheapest way for laser fabrication of doped biocompatible coating is to cover the rotating target material (matrix) with a piece of dopant material. But in present study of layers, multilayers and superlattices of doped biocompatible materials the focus is on increasing flexibility and range of deposition conditions by way of combining PLD with magnetron sputtering (MS), PLD with RF discharges, ion gun layers modification and on the combination of two simultaneously running PLD systems (dual PLD). The methods allow carefully study the influence of dopation on a large scale of dopants and to create nanocomposite biomaterials of new properties [2] Experiences with deposition of chromium, silver and titanium doped diamond-like carbon (DLC) and hydroxyapatite (HA) films and ferroelectric BaTiO3 multilayers for coating of metallic bone implants are presented. Layers of different dopants concentration and ferroelectric-based multilayers were prepared. Overwiev of our research in that direction and the results of physical and biomedical analysis are presented in summary. The doped and multilayer biocompatible coatings were prepared by PLD, PLD combined with radiofrequency discharges (RF), PLD with magnetron sputtering (MS), PLD with ion bombardment, and by dual PLD. The two KrF excimer lasers (LUMONICS PM 842, λ = 248 nm, τ = 20 ns and COMPexProTM 205 F, λ = 248 nm, τ = 20 ns) were used. (Fig. 1) The energy density of laser beam on the target ranged from 2 to 16 Jcm -2 , repetition rate of pulses were from 1 to 50 Hz, argon atmosphere pressure from 10 -4 Pa (vacuum) to 1 Pa. Thin layers of DLC were deposited on fused silica (FS), Si (100) or metallic substrates. The substrate deposition temperature for DLC films was T S = 20°C. The target-substrate distance (D T-S ) was 45 mm for PLD, 85 mm for MS, and 260 mm for ion bo...

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Biomedical properties of laser prepared silver-doped hydroxyapatite

Cited by 19 publications

References 15 publications

Antimicrobial dental implant functionalization strategies —A systematic review

Antimicrobial dental implant functionalization strategies —A systematic review

Silver doped metal layers for medical applications

Doped and Multilayer Biocompatible Materials Prepared by Hybrid Laser Deposition

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