Biomedical probe using a fiber‐optic coupled scintillator

Swinth, K.L.; Ewins, J.H.

doi:10.1118/1.594274

Cited by 21 publications

(4 citation statements)

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“…Colton and Hardy designed a portable gamma-ray detection probe for intraoperative use [3]. A similar system was described by Swinth and Ewins [24]. Harvey and Lancaster de- signed a surgical biopsy probe based on the same principles and gave a full technical description of this system [12].…”

Section: Discussionmentioning

confidence: 99%

Intraoperative radioactive localization of small bone tumours

Boeck

Casteleyn

Bossuyt

et al. 1992

International Orthopaedics

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A sodium-iodide scintillation probe and a portable scaler rate-metre were used to localize small bone tumours at operation, after the preoperative injection of technetium-99m methylene diphosphonate. This technique allows complete removal of the tumour nidus of an osteoid osteoma or the active part of other lesions without undue sacrifice of the surrounding bone. The method has been used for successful relief of pain in thirteen patients.

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Section: Discussionmentioning

confidence: 99%

Intraoperative radioactive localization of small bone tumours

Boeck

Casteleyn

Bossuyt

et al. 1992

International Orthopaedics

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“…To the best of our knowledge, Swinth et al [ 50 ] first applied IOSFD for low-background, low-energy biomedical photon counting. The biomedical radiation-sensitive probe comprised a large piece of NaI : Tl crystal coupled to a bundle of glass optical fibers.…”

Section: Development Of Iosfdsmentioning

confidence: 99%

Advances on inorganic scintillator-based optic fiber dosimeters

Ding

Wang³

et al. 2020

EJNMMI Phys

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This article presents a new perspective on the development of inorganic scintillator-based fiber dosimeters (IOSFDs) for medical radiotherapy dosimetry (RTD) focusing on real-time in vivo dosimetry. The scintillator-based optical fiber dosimeters (SFD) are compact, free of electromagnetic interference, radiation-resistant, and robust. They have shown great potential for real-time in vivo RTD. Compared with organic scintillators (OSs), inorganic scintillators (IOSs) have larger X-ray absorption and higher light output. Variable IOSs with maximum emission peaks in the red part of the spectrum offer convenient stem effect removal. This article outlines the main advantages and disadvantages of utilizing IOSs for SFD fabrication. IOSFDs with different configurations are presented, and their use for dosimetry in X-ray RT, brachytherapy (BT), proton therapy (PT), and boron neutron capture therapy (BNCT) is reviewed. Challenges including the percentage depth dose (PDD) deviation from the standard ion chamber (IC) measurement, the angular dependence, and the Cherenkov effect are discussed in detail; methods to overcome these problems are also presented.

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“…Consequently, there is an interest in the development of devices that can image radiotracers in an intraoperative setting. Early imaging devices have focused on the detection of gamma radiation and have found use both in clinical trials and the clinic 10 11 12 13 14 15 . The disadvantage of imaging gamma radiation is that gamma rays travel many centimeters through tissue before they can be detected, leading to decreased resolution and a high level of background signal from distant tissue that may have high tracer uptake.…”

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confidence: 99%

Endoscopic detection of cancer with lensless radioluminescence imaging and machine vision

Türkcan

Naczynski

Nolley

et al. 2016

Sci Rep

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Complete removal of residual tumor tissue during surgical resection improves patient outcomes. However, it is often difficult for surgeons to delineate the tumor beyond its visible boundary. This has led to the development of intraoperative detectors that can image radiotracers accumulated within tumors, thus facilitating the removal of residual tumor tissue during surgical procedures. We introduce a beta imaging system that converts the beta radiation from the radiotracer into photons close to the decay origin through a CdWO4 scintillator and does not use any optical elements. The signal is relayed onto an EMCCD chip through a wound imaging fiber. The sensitivity of the device allows imaging of activity down to 100 nCi and the system has a resolution of at least 500 μm with a field of view of 4.80 × 6.51 mm. Advances in handheld beta cameras have focused on hardware improvements, but we apply machine vision to the recorded images to extract more information. We automatically classify sample regions in human renal cancer tissue ex-vivo into tumor or benign tissue based on image features. Machine vision boosts the ability of our system to distinguish tumor from healthy tissue by a factor of 9 ± 3 and can be applied to other beta imaging probes.

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Biomedical probe using a fiber‐optic coupled scintillator

Cited by 21 publications

References 0 publications

Intraoperative radioactive localization of small bone tumours

Intraoperative radioactive localization of small bone tumours

Advances on inorganic scintillator-based optic fiber dosimeters

Endoscopic detection of cancer with lensless radioluminescence imaging and machine vision

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