Biomedical nanomaterials in tissue engineering

Kim, N.J.; Lee, S.J.; Atala, Anthony

doi:10.1533/9780857097231.1

Cited by 16 publications

(13 citation statements)

References 105 publications

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“…Nano-scale particles are increasingly used in TE, this is due to the natural mimics of biological environments that could restore and enhance the physiological function in livings tissue or organs. 96 Other than that, nanomaterials are expected to influence the TE applications to achieve successful implantations in the future development of nanotechnology.…”

Section: Biomaterials Used In Tementioning

confidence: 99%

A review of biomaterials scaffold fabrication in additive manufacturing for tissue engineering

Shick

Kadir

Ngadiman

et al. 2019

Journal of Bioactive and Compatible Polymers

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The current developments in three-dimensional printing also referred as “additive manufacturing” have transformed the scenarios for modern manufacturing and engineering design processes which show greatest advantages for the fabrication of complex structures such as scaffold for tissue engineering. This review aims to introduce additive manufacturing techniques in tissue engineering, types of biomaterials used in scaffold fabrication, as well as in vitro and in vivo evaluations. Biomaterials and fabrication methods could critically affect the outcomes of scaffold mechanical properties, design architectures, and cell proliferations. In addition, an ideal scaffold aids the efficiency of cell proliferation and allows the movements of cell nutrient inside the human body with their specific material properties. This article provides comprehensive review that covers broad range of all the biomaterial types using various additive manufacturing technologies. The data were extracted from 2008 to 2018 mostly from Google Scholar, ScienceDirect, and Scopus using keywords such as “Additive Manufacturing,” “3D Printing,” “Tissue Engineering,” “Biomaterial” and “Scaffold.” A 10 years research in this area was found to be mostly focused toward obtaining an ideal scaffold by investigating the fabrication strategies, biomaterials compatibility, scaffold design effectiveness through computer-aided design modeling, and optimum printing machine parameters identification. As a conclusion, this ideal scaffold fabrication can be obtained with the combination of different materials that could enhance the material properties which performed well in optimum additive manufacturing condition. Yet, there are still many challenges from the printing methods, bioprinting and cell culturing that needs to be discovered and investigated in the future.

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Section: Biomaterials Used In Tementioning

confidence: 99%

A review of biomaterials scaffold fabrication in additive manufacturing for tissue engineering

Shick

Kadir

Ngadiman

et al. 2019

Journal of Bioactive and Compatible Polymers

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“…Elastin and gelatin/elastin nanocomposites have been proposed to play a role in vascular grafting. PLA/gelatin nanofibers have acted as a good support for the adhesion of cells and also promoted the viability and proliferation of HUVEC and human smooth muscle cells critical for vascular engineering …”

Section: Vascular Tementioning

confidence: 99%

“…NMs possess better physical and chemical properties and have superior biocompatibility as compared to bulk molecules from which these are synthesized. The properties of NMs can be altered easily by modifying the fabrication process and method of assembly . NMs consist of nanotubes, dendrimers, nanofibers, nanoparticles (NPs), nanowires, and many other nanostructural forms .…”

Section: Introductionmentioning

confidence: 99%

“…The properties of NMs can be altered easily by modifying the fabrication process and method of assembly. 8 NMs consist of nanotubes, dendrimers, nanofibers, nanoparticles (NPs), nanowires, and many other nanostructural forms. 9 Nanotechnology-based materials can be synthesized to release and deliver important growth factors or bioactive molecules to the targeted damaged organs/tissues.…”

Section: Introductionmentioning

confidence: 99%

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Nanomaterials as potential and versatile platform for next generation tissue engineering applications

et al. 2019

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Tissue engineering (TE) is an emerging field where alternate/artificial tissues or organ substitutes are implanted to mimic the functionality of damaged or injured tissues. Earlier efforts were made to develop natural, synthetic, or semisynthetic materials for skin equivalents to treat burns or skin wounds. Nowadays, many more tissues like bone, cardiac, cartilage, heart, liver, cornea, blood vessels, and so forth are being engineered using 3‐D biomaterial constructs or scaffolds that could deliver active molecules such as peptides or growth factors. Nanomaterials (NMs) due to their unique mechanical, electrical, and optical properties possess significant opportunities in TE applications. Traditional TE scaffolds were based on hydrolytically degradable macroporous materials, whereas current approaches emphasize on controlling cell behaviors and tissue formation by nano‐scale topography that closely mimics the natural extracellular matrix. This review article gives a comprehensive outlook of different organ specific NMs which are being used for diversified TE applications. Varieties of NMs are known to serve as biological alternatives to repair or replace a portion or whole of the nonfunctional or damaged tissue. NMs may promote greater amounts of specific interactions stimulated at the cellular level, ultimately leading to more efficient new tissue formation. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 2433–2449, 2019.

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“…Biomedical applications of nanotechnology became a hot subject because different nanomaterials are utilized for the synthesis of scaffolds or implants [ 23 , 24 ]. These nanomaterials may be metallic [ 25 ], ceramic, or polymeric [ 26 ] with different structural forms such as tubes, rods, fibers, and spheres [ 27 ]. Various properties of materials such as physiochemical, electrical, mechanical, optical, catalytic, and magnetic properties can be improved at the nanoscale [ 28 ] and tailored to specific applications.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Survey on Nanobiomaterials for Bone Tissue Engineering Applications

et al. 2020

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One of the most important ideas ever produced by the application of materials science to the medical field is the notion of biomaterials. The nanostructured biomaterials play a crucial role in the development of new treatment strategies including not only the replacement of tissues and organs, but also repair and regeneration. They are designed to interact with damaged or injured tissues to induce regeneration, or as a forest for the production of laboratory tissues, so they must be micro-environmentally sensitive. The existing materials have many limitations, including impaired cell attachment, proliferation, and toxicity. Nanotechnology may open new avenues to bone tissue engineering by forming new assemblies similar in size and shape to the existing hierarchical bone structure. Organic and inorganic nanobiomaterials are increasingly used for bone tissue engineering applications because they may allow to overcome some of the current restrictions entailed by bone regeneration methods. This review covers the applications of different organic and inorganic nanobiomaterials in the field of hard tissue engineering.

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Biomedical nanomaterials in tissue engineering

Cited by 16 publications

References 105 publications

A review of biomaterials scaffold fabrication in additive manufacturing for tissue engineering

A review of biomaterials scaffold fabrication in additive manufacturing for tissue engineering

Nanomaterials as potential and versatile platform for next generation tissue engineering applications

Comprehensive Survey on Nanobiomaterials for Bone Tissue Engineering Applications

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