Biomedical nanomaterials for imaging-guided cancer therapy

Huang, Yongfeng; He, Sha; Cao, Weipeng; Cai, Kaiyong; Liang, Xing‐Jie

doi:10.1039/c2nr31715j

Cited by 194 publications

(130 citation statements)

References 124 publications

(120 reference statements)

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“…Multimodal imaging exploits the advantages of complementary imaging techniques while compensating each other's limitations. By combining optical, magnetic, and photoacoustic imaging (PAI), the QRs can offer high spatial resolution in three dimensions (MRI and PAI), excellent contrast between soft tissues (MRI), high sensitivity (fluorescent imaging, FLI), and high temporal resolution (within seconds) at low cost (FLI), as well as the ability to image across a range of scales (millimeter to hundreds of microns for MRI and PAI respectively) (13,32,33).…”

Section: Resultsmentioning

confidence: 99%

“…These constructs promise to integrate various functionalities by incorporating different nanomaterials into a single, efficient, multimodal system (12,13). However, these systems usually accumulate the specific functionalities of their component modules through multiple steps in their synthetic processes, thereby adding complexity at the expense of performance (11).…”

mentioning

confidence: 99%

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Gold–silica quantum rattles for multimodal imaging and therapy

Hembury

Chiappini

Bertazzo

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

107

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Gold quantum dots exhibit distinctive optical and magnetic behaviors compared with larger gold nanoparticles. However, their unfavorable interaction with living systems and lack of stability in aqueous solvents has so far prevented their adoption in biology and medicine. Here, a simple synthetic pathway integrates gold quantum dots within a mesoporous silica shell, alongside larger gold nanoparticles within the shell's central cavity. This "quantum rattle" structure is stable in aqueous solutions, does not elicit cell toxicity, preserves the attractive near-infrared photonics and paramagnetism of gold quantum dots, and enhances the drug-carrier performance of the silica shell. In vivo, the quantum rattles reduced tumor burden in a single course of photothermal therapy while coupling three complementary imaging modalities: near-infrared fluorescence, photoacoustic, and magnetic resonance imaging. The incorporation of gold within the quantum rattles significantly enhanced the drug-carrier performance of the silica shell. This innovative material design based on the mutually beneficial interaction of gold and silica introduces the use of gold quantum dots for imaging and therapeutic applications.nanomedicine | hybrid nanoparticle | cancer nanotechnology | gold quantum dots | mesoporous silica A lthough gold's potential in nanotechnology has been recognized for many decades (1, 2), new insights into the unique properties of gold nanoparticles (NPs) of less than 2 nm have just recently started to emerge (3, 4). Such extremely small gold NPs could be transformative for a broad set of applications ranging from energy production and storage to catalysis and health care (3). As the size of gold NPs decreases below 2 nm, the quantization of their conduction band leads to molecule-like properties (3). These quantum-sized gold NPs (or gold quantum dots, AuQDs) absorb light in the near-infrared (NIR) biological window (650-900 nm) (2) and convert it into photons and heat (5). Furthermore, whereas bulk gold is diamagnetic, some AuQDs exhibit magnetic properties (4, 6). However, the clear therapeutic and imaging potential of AuQDs in vivo has been undermined by their unfavorable biointeractions and lack of stability in aqueous solvents (5, 7). In biological environments AuQDs tend to aggregate rapidly, reverting to larger gold nanoparticles (AuNPs) (8) and/or bind to protein, which negatively affects their cytotoxicity (7). To retain their advantages, AuQDs require a protective, stabilizing framework that allows proficient biological interactions.Recently, new emphasis has been placed on hybrid NP systems, where multiple nanomaterials are assembled to create multimodal systems that exhibit the combined qualities of the component modules (9-11). These constructs promise to integrate various functionalities by incorporating different nanomaterials into a single, efficient, multimodal system (12, 13). However, these systems usually accumulate the specific functionalities of their component modules through multiple steps in their ...

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Gold–silica quantum rattles for multimodal imaging and therapy

Hembury

Chiappini

Bertazzo

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

107

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“…2 As a result, a new discipline, known as "molecular imaging" (MI) has emerged, which combines molecular biology and in vivo imaging. 3 The aim of MI is to monitor and measure biological processes in living subjects via spectral data. The measurement and monitoring of biological processes provides information similar to that from a biopsy, but it is noninvasive and performed in real time, thereby offering the possibility of sequential and longitudinal monitoring.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents

Estelrich¹,

Sánchez-Martín²,

Busquets³

2015

IJN

262

106

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Magnetic resonance imaging (MRI) has become one of the most widely used and powerful tools for noninvasive clinical diagnosis owing to its high degree of soft tissue contrast, spatial resolution, and depth of penetration. MRI signal intensity is related to the relaxation times ( T 1 , spin–lattice relaxation and T 2 , spin–spin relaxation) of in vivo water protons. To increase contrast, various inorganic nanoparticles and complexes (the so-called contrast agents) are administered prior to the scanning. Shortening T 1 and T 2 increases the corresponding relaxation rates, 1/ T 1 and 1/ T 2 , producing hyperintense and hypointense signals respectively in shorter times. Moreover, the signal-to-noise ratio can be improved with the acquisition of a large number of measurements. The contrast agents used are generally based on either iron oxide nanoparticles or ferrites, providing negative contrast in T 2 -weighted images; or complexes of lanthanide metals (mostly containing gadolinium ions), providing positive contrast in T 1 -weighted images. Recently, lanthanide complexes have been immobilized in nanostructured materials in order to develop a new class of contrast agents with functions including blood-pool and organ (or tumor) targeting. Meanwhile, to overcome the limitations of individual imaging modalities, multimodal imaging techniques have been developed. An important challenge is to design all-in-one contrast agents that can be detected by multimodal techniques. Magnetoliposomes are efficient multimodal contrast agents. They can simultaneously bear both kinds of contrast and can, furthermore, incorporate targeting ligands and chains of polyethylene glycol to enhance the accumulation of nanoparticles at the site of interest and the bioavailability, respectively. Here, we review the most important characteristics of the nanoparticles or complexes used as MRI contrast agents.

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“…All aqueous solutions were prepared with deionized water obtained using a Milli-Q ultrafiltration system (Millipore Corporation, Billerica, MA, USA) with a measured resistivity above 18 mΩ. 1 H nuclear magnetic resonance (NMR) and 13 C NMR spectra were recorded using CDCl 3 or dimethyl sulfoxide solutions at 400 mHz and 600 mHz for 1 H and 100.6 mHz and 150.92 mHz for 13 C. Infrared spectra were recorded on a model 257 grating spectrometer (PerkinElmer, Boston, MA, USA). Mass spectra were obtained using an electrospray ionization source; all electrospray ionization source mass spectra were performed using methanol as the solvent.…”

Section: Materials and Methods Chemicals And Instrumentsmentioning

confidence: 99%

“…[4][5][6][7][8][9][10][11] In order to fully exploit their potential, magnetic nanoparticles are often engineered by conjugation with biomolecules to target specific cells. The scientific community is seeking to obtain medical breakthroughs in diagnosis and therapy, 12,13 giving rise to the concept of theranostics.…”

Section: Introductionmentioning

confidence: 99%

In vivo anticancer evaluation of the hyperthermic efficacy of anti-human epidermal growth factor receptor-targeted PEG-based nanocarrier containing magnetic nanoparticles

Baldi¹,

Ravagli²,

Mazzantini³

et al. 2014

IJN

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Polymeric nanoparticles with targeting moieties containing magnetic nanoparticles as theranostic agents have considerable potential for the treatment of cancer. Here we report the chemical synthesis and characterization of a poly(D,L-lactide- co -glycolide)- b -poly(ethylene glycol)-based nanocarrier containing iron oxide nanoparticles and human epithelial growth factor receptor on the outer shell. The nanocarrier was also radiolabeled with 99m Tc and tested as a theranostic nanomedicine, ie, it was investigated for both its diagnostic ability in vivo and its therapeutic hyperthermic effects in a standard A431 human tumor cell line. Following radiolabeling with 99m Tc, the biodistribution and therapeutic hyperthermic effects of the nanosystem were studied noninvasively in vivo in tumor-bearing mice. A substantial decrease in tumor size correlated with an increase in both nanoparticle concentration and local temperature was achieved, confirming the possibility of using this multifunctional nanosystem as a therapeutic tool for epidermoid carcinoma.

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Biomedical nanomaterials for imaging-guided cancer therapy

Cited by 194 publications

References 124 publications

Gold–silica quantum rattles for multimodal imaging and therapy

Gold–silica quantum rattles for multimodal imaging and therapy

Nanoparticles in magnetic resonance imaging: from simple to dual contrast agents

In vivo anticancer evaluation of the hyperthermic efficacy of anti-human epidermal growth factor receptor-targeted PEG-based nanocarrier containing magnetic nanoparticles

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