Biomedical microdevices for neural interfaces

Meyer, J.-U.; Schüttler, Martin; Thielecke, Hagen

doi:10.1109/mmb.2000.893824

Cited by 14 publications

(5 citation statements)

References 6 publications

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“…Optimal elaboration algorithms should also be studied, so that to get the most from the actuation response, depending on the application of interest. Non-invasive recording electrodes are obviously preferable with respect to invasive solutions, even though the latter can provide more selective and less noisy signals, as in the case of cuff electrodes (less invasive and less selective) or sieve electrodes (more invasive -the nerve grows through-but much more selective) 17 . As a final remark, a clarification on the use of the term activation can be made.…”

Section: Resultsmentioning

confidence: 99%

Activation of dielectric elastomer actuators by means of human electrophysiological signals

Carpi¹,

Raspopović²,

Rossi³

2006

SPIE Proceedings

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The assessed high electromechanical performances of dielectric elastomer actuators are encouraging the study of possible future applications of such devices for active prosthetic or orthotic systems for humans. Although the high electric fields currently needed for their driving prevent today a short-term use in endo-prostheses, their adoption for eso-prostheses or orthoses can be considered more realistic. Exoskeletons for improving muscular performance in specific tasks or for rehabilitation are examples of possible fields of investigation. Beyond a necessary technological development towards materials and devices capable of improved performances at reduced fields, the study of such applications requires even the identification of suitable strategies of activation and control. In particular, actuators to be used for such applications may take advantage from the possibility of being activated by electrophysiological signals. This would permit advantageous body's controls of the artificial system. In this context, this work presents activities carried on towards such a goal. In particular, activations of silicone-made dielectric elastomer actuators by means of different types of electrophysiological signals, opportunely elaborated, are presented and discussed.

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Section: Resultsmentioning

confidence: 99%

Activation of dielectric elastomer actuators by means of human electrophysiological signals

Carpi¹,

Raspopović²,

Rossi³

2006

SPIE Proceedings

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“…The biologically applications for MEMS is knows as BioMEMS, that describes devices and structures for analytical applications, such as biomolecular recognition and affinity sensors [18,19], devices for chemical and enzymatic diagnostic analyses [20][21][22][23], porous filters fabricated in micro-channels used for bio-cell separation and ELISA [24], impedance measurements for high-throughput drug screening [25], different types of valves for microfluidic use [26][27][28], and a magnetic mixer [29], MEMS structures for microdialysis [30], arrayed microholes for gene therapy applications [31], microfabricated dispensing devices with a precision pipetting head [32] and a drop dispenser [33], and microfabricated templates for scaffolds used in tissue engineering [34].…”

Section: Drug Delivery Using Memsmentioning

confidence: 99%

An Integrated Platform for Bio-Analysis and Drug Delivery

Amer¹,

Badawy

2005

CPB

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The advances in the microelectronics fabrication allow the strong appearance of micro-electro-mechanical systems known as MEMS. MEMS enable the fabrication of smaller devices that are manufactured using standard micro-fabrication techniques similar to the ones that are used to create computer silicon chips. Several MEMS devices including micro-reservoirs, micro-pumps, cantilevers, rotors, channels, valves, sensors, and other structures have been designed, fabricated and tested from using materials that have been demonstrated to be biocompatible. This paper reviews the status of Micro-electronic and MEMS systems that can be used for adaptive drug administration. It presents different components and describes a possible implementation. Finally it presents a prototype that is termed ipill which stands intelligent pill.

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“…The implication of this result is important. From a classical standpoint, the miniaturisation of chemical cell-adhesive micropatterns towards single-neuron size dimensions (10 pm) is considered to be appealing, as it allows a more precise positioning of cells on small, pre-defined areas (SINGHVI et al, 1994) such as micro-electrodes (MEYER et al, 2000;(BUITENWEG et al, 1998). However, the unwanted side effect is the accelerated death of neuronal tissue and faster overgrowth of neurites over the pattern after longer periods of time, owing to the smaller gaps between the neuron-adhesive areas.…”

Section: Medical and Biological Engineering And Computing 2003 Vol 41mentioning

confidence: 99%

Long-term adhesion and survival of dissociated cortical neurons on miniaturised chemical patterns

Ruardij¹,

Goedbloed²,

Rutten³

2003

Med. Biol. Eng. Comput.

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The influence of neuron-adhesive pattern geometry on long-term adhesion, survival and pattern compliance of cortical neuronal tissue was studied over a period of 15 days. The results are relevant for a successful, long-term integration of neuronal cells with electrodes from micro-electronic devices. Microwells (depth 0.5 microm), with diameters of 25, 50, 100 and 150 microm and spacing distances of 15, 30, 60 and 90 microm, were etched in a neuron-repellent fluorocarbon (FC) layer and coated with neuron-adhesive polyethylenimine (PEI). Results showed that adhesion, survival and compliance to the underlying patterns were geometry- and time-dependent. After 1 day, adhesion was inversely proportional to the diameter of the microwells, thus favouring the 25 microm microwells. However, adhesion was best on 50 microm microwells after 15 days. Survival of neurons was limited on 25 microm microwells (viability function V(D, T) was 0.08), as opposed to the better survival on 150 microm microwells (V(D, T) was 0.25) after 15 days. In summary, the study shows that the chemical patterns with microwells of 150 microm diameter (90 microm spacing gap) are most suitable for application on neuro-electronic devices owing to the better long-term survival and high pattern compliance of the neuronal cells.

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Biomedical microdevices for neural interfaces

Cited by 14 publications

References 6 publications

Activation of dielectric elastomer actuators by means of human electrophysiological signals

Activation of dielectric elastomer actuators by means of human electrophysiological signals

An Integrated Platform for Bio-Analysis and Drug Delivery

Long-term adhesion and survival of dissociated cortical neurons on miniaturised chemical patterns

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