Biomedical Materials: Engineered Bacterial Bioreactor for Tumor Therapy via Fenton‐Like Reaction with Localized H<sub>2</sub>O<sub>2</sub> Generation (Adv. Mater. 16/2019)

Fan, Jin‐Xuan; Peng, Mengyun; Wang, He; Zheng, Haoran; Liu, Zonglin; Li, Chu‐Xin; Wang, Xia‐Nan; Liu, Xinhua; Cheng, Si‐Xue; Zhang, Xian‐Zheng

doi:10.1002/adma.201970119

Cited by 27 publications

(22 citation statements)

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“…[ 11a,157 ] In addition, some physical methods have been developed to temporarily open the BBB and also achieve the purpose of brain‐targeted drug delivery. [ 158 ] It is worth mentioning that for brain diseases such as ICH, nasal delivery is a suitable method of administration. Some studies have focused on the use of nasal delivery to treat ICH.…”

Section: Discussionmentioning

confidence: 99%

The Development of Drug Delivery Systems for Efficient Intracranial Hemorrhage Therapy

Liu

Zhou

et al. 2023

Adv Healthcare Materials

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Intracerebral hemorrhage (ICH) is the most devastating form of stroke, which accounts for 10-15% of cases and causes high morbidity and mortality. With the continuous exploration of the pathological mechanism of ICH, extensive research focusing on ICH therapy has been conducted. However, the traditional treatment methods, such as surgery for removing the hematoma and pharmacotherapy for improving the clearance of the hematoma and neuroprotection, are greatly limited due to their poor practicality and treatment efficiency. The rapid development of drug delivery systems offers an important prospect for treating ICH as they exhibit great versatility, which can improve the pharmacokinetic behavior of drugs in vivo, increase the drug accumulation in specific cell types or tissues, and enhance the therapeutic effect with diminished toxic effect. In this review, the main molecular pathological mechanisms of ICH are comprehensively described and the limitation of traditional pharmacotherapy are also discussed. Then the development based on drug delivery systems for treating ICH is highlighted. Finally, based on these discussions the challenges of drug delivery systems with a view to providing a new feasible path for the treatment of ICH are summarized.

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Section: Discussionmentioning

confidence: 99%

The Development of Drug Delivery Systems for Efficient Intracranial Hemorrhage Therapy

Liu

Zhou

et al. 2023

Adv Healthcare Materials

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“…Recently, therapeutic Fenton-like reactions for generating toxic ROS have received increasing attention. One example is the use of a Fenton-like bioreactor composed of magnetic Fe 3 O 4 nanoparticle-decorated E. coli MG1655 overexpressing respiratory chain enzyme II (NDH-2) [63]. In this constructed bioreactor, the Fenton-like reaction occurs with continuously generated H 2 O 2 produced by engineered bacteria, and abundant tumor cell apoptosis is triggered by the produced cytotoxic hydroxyl radicals ( • OH).…”

Section: Synergistic Bacteria-mediated Photothermal Therapymentioning

confidence: 99%

“…Certain bacteria-based self-supplied therapeutic Fenton-like bioreactors offer a promising approach to eliminate tumor cells and have shown great potential in biomedical fields (Fig. 5) [63].…”

Section: Synergistic Bacteria-mediated Photothermal Therapymentioning

confidence: 99%

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Bacteria-Mediated Synergistic Cancer Therapy: Small Microbiome Has a Big Hope

et al. 2021

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The use of bacteria to specifically migrate to cancerous tissue and elicit an antitumor immune response provides a promising platform against cancer with significantly high potency. With dozens of clinical trials underway, some researchers hold the following views: “humans are nearing the first commercial live bacteria therapeutic.” However, the facultative anaerobe Salmonella typhimurium VNP20009, which is particularly safe and shows anticancer effects in preclinical studies, had failed in a phase I clinical trial due to low tumor regression and undesired dose-dependent side effects. This is almost certain to disappoint people’s inflated expectations, but it is noted that recent state-of-the-art research has turned attention to bacteria-mediated synergistic cancer therapy (BMSCT). In this review, the foundation of bacteria-mediated bio-therapy is outlined. Then, we summarize the potential benefits and challenges of bacterial bio-therapy in combination with different traditional anticancer therapeutic modalities (chemotherapy, photothermal therapy, reactive oxygen and nitrogen species therapy, immunotherapy, or prodrug-activating therapy) in the past 5 years. Next, we discuss multiple administration routes of BMSCT, highlighting potentiated antitumor responses and avoidance of potential side effects. Finally, we envision the opportunities and challenges for BMSCT development, with the purpose of inspiring medicinal scientists to widely utilize the microbiome approach in patient populations.

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“…In 2016, Zhang et al reported the first Fe-based nanocatalyst, amorphous Fe, which can be used to generate •OH in MCF-7 cells via classical Fenton reaction. 10 After that, many iron-containing nanostructures (MON-P53, 18 rMOF-FA, 19 SnFe 2 O 4 , 13 MCDION-Se, 20 Ec-pE@MNP, 21 FMDF NPs, 22 MnSiO 3 @ Fe 3 O 4 , 23 and FcPWNPs 24 ) have been designed and fabricated for triggering the process of CDT. In 2018, Wang et al 25 fabricated a multifunctional polymeric nanoparticle which contained ferrocene carboxylic acid hexadecyl ester (DFc) and ascorbyl palmitate (PA) block.…”

Section: Metal-based Nanocatalyst For Cdtmentioning

confidence: 99%

Metal-Based Nanocatalyst for Combined Cancer Therapeutics

et al. 2020

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As a classical nanocatalyst-based therapeutic modality, chemodynamic therapy (CDT) has received more and more attention. To improve the therapeutic efficacy of CDT, various metal-based nanocatalysts have been designed and constructed to catalyze the Fenton or Fenton-like reaction in the past few years. However, the therapeutic efficacy of certain CDT is still restricted by the tumor microenvironment, such as limited concentration of intracellular H2O2, inappropriate pH condition, as well as overexpressed glutathione (GSH). Therefore, many other therapeutic modalities, such as photodynamic therapy (PDT), photothermal therapy (PTT), starvation therapy, chemotherapy, and gas therapy, have been utilized to combine with CDT for increasing the tumor treatment performance. In this review, we summarized the development of combinatory therapeutic modalities based on CDT in recent years.

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Biomedical Materials: Engineered Bacterial Bioreactor for Tumor Therapy via Fenton‐Like Reaction with Localized H₂O₂ Generation (Adv. Mater. 16/2019)

Cited by 27 publications

References 0 publications

The Development of Drug Delivery Systems for Efficient Intracranial Hemorrhage Therapy

The Development of Drug Delivery Systems for Efficient Intracranial Hemorrhage Therapy

Bacteria-Mediated Synergistic Cancer Therapy: Small Microbiome Has a Big Hope

Metal-Based Nanocatalyst for Combined Cancer Therapeutics

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Biomedical Materials: Engineered Bacterial Bioreactor for Tumor Therapy via Fenton‐Like Reaction with Localized H2O2 Generation (Adv. Mater. 16/2019)

Cited by 27 publications

References 0 publications

The Development of Drug Delivery Systems for Efficient Intracranial Hemorrhage Therapy

The Development of Drug Delivery Systems for Efficient Intracranial Hemorrhage Therapy

Bacteria-Mediated Synergistic Cancer Therapy: Small Microbiome Has a Big Hope

Metal-Based Nanocatalyst for Combined Cancer Therapeutics

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Biomedical Materials: Engineered Bacterial Bioreactor for Tumor Therapy via Fenton‐Like Reaction with Localized H₂O₂ Generation (Adv. Mater. 16/2019)