Biomedical device prototype based on small scale hydrodynamic cavitation

Abstract

This study presents a biomedical device prototype based on small scale hydrodynamic cavitation. The application of small scale hydrodynamic cavitation and its integration to a biomedical device prototype is offered as an important alternative to other techniques, such as ultrasound therapy, and thus constitutes a local, cheap, and energy-efficient solution, for urinary stone therapy and abnormal tissue ablation (e.g., benign prostate hyperplasia (BPH)). The destructive nature of bubbly, cavitating, flows was exploited, and the potential of the prototype was assessed and characterized. Bubbles generated in a small flow restrictive element (micro-orifice) based on hydrodynamic cavitation were utilized for this purpose. The small bubbly, cavitating, flow generator (micro-orifice) was fitted to a small flexible probe, which was actuated with a micromanipulator using fine control. This probe also houses an imaging device for visualization so that the emerging cavitating flow could be locally targeted to the desired spot. In this study, the feasibility of this alternative treatment method and its integration to a device prototype were successfully accomplished.

Design and fabrication of a vigorous “cavitation-on-a-chip” device with a multiple microchannel configuration

“…However, applications of HC at the conventional scale have been successfully realized in the food and beverage industry [4][5][6] and hydrometallurgy 7 . Furthermore, its extensive applications at the microscale are emerging, such as wastewater treatment 8 , biomedical applications [9][10][11] , energy harvesting 12,13 , and liquid phase exfoliation 14 .…”

Localization and quantification of radical production in cavitating flows with luminol chemiluminescent reactions

“…Finally, the microfluidic channels can often ease the implementation of optical probing methods. In spite of these advantages, the research field on the topic of cavitation in microchannels involves only a few groups [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] .…”

Local Carpet Bombardment of Immobilized Cancer Cells With Hydrodynamic Cavitation

“…Due to a wide variety of potential cavitation applications, many researchers have conducted studies on the cavitation physics to facilitate earlier inception [3], [4] and to intensify cavitating flows [5]. The energy released from the collapse of cavitation bubbles has been effectively employed for various applications such as wastewater treatment [6], food manufacturing [7], energy harvesting [8], [9], bacterial inactivation [10], biomedical treatment [11], and other industrial applications [12]. The use of hydrodynamic cavitation in biomedical applications is an emerging field in the literature.…”