Biomedical Applications Polymer Blends

Eastmond, G. C.; Höcker, Hartwig; Klee, Doris

doi:10.1007/3-540-48838-3

Advances in Polymer Science 1999

DOI: 10.1007/3-540-48838-3

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Biomedical Applications Polymer Blends

G. C. Eastmond¹,

Hartwig Höcker²,

Doris Klee³

Abstract: ~ Spri ngerThis series presents critical reviews of the present and future trends in polymer and biopolymer science including chemistry, physical chemistry, physics and materials science. It is addressed to all scientists at universities and in industry who wish to keep abreast of advances in the topics covered.As a rule, contributions are specially commissioned. The editors and publishers will, however, always be pleased to receive suggestions and supplementary information.

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Cited by 11 publications

References 45 publications

(187 reference statements)

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Effect of bisphenol A on the miscibility, phase morphology, and specific interaction in immiscible biodegradable poly(ε‐caprolactone)/poly(L‐lactide) blends

Kuo

Huang

Tung

et al. 2006

J of Applied Polymer Sci

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ABSTRACT:We have investigated the enhancement in miscibility, upon addition of bisphenol A (BPA) of immiscible binary biodegradable blends of poly(-caprolactone) (PCL) and poly(l-lactide) (PLLA). That BPA is miscible with both PCL and PLLA was proven by the single value of T g observed by differential scanning calorimetry (DSC) analyses over the entire range of compositions. At various compositions and temperatures, Fourier transform infrared spectroscopy confirmed that intermolecular hydrogen bonding existed between the hydroxyl group of BPA and the carbonyl groups of PCL and PLLA. The addition of BPA enhances the miscibility of the immiscible PCL/PLLA binary blend and transforms it into a miscible blend at room temperature when a sufficient quantity of the BPA is present. In addition, optical microscopy (OM) measurements of the phase morphologies of ternary BPA/PCL/ PLLA blends at different temperatures indicated an upper critical solution temperature (UCST) phase diagram, since the ⌬K effect became smaller at higher temperature (200°C) than at room temperature. An analysis of infrared spectra recorded at different temperatures correlated well with the OM analyses.

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Effect of bisphenol A on the miscibility, phase morphology, and specific interaction in immiscible biodegradable poly(ε‐caprolactone)/poly(L‐lactide) blends

Kuo

Huang

Tung

et al. 2006

J of Applied Polymer Sci

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Crystallization behavior of poly(ϵ‐caprolactone) in poly(ϵ‐caprolactone) and poly(vinyl methyl ether) mixtures

Meng

Huo

et al. 2007

J of Applied Polymer Sci

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ABSTRACT:The morphological development and crystallization behavior of poly(e-caprolactone) (PCL) in miscible mixtures of PCL and poly(vinyl methyl ether) (PVME) were investigated by optical microscopy as a function of the mixture composition and crystallization temperature. The results indicated that the degree of crystallinity of PCL was independent of the mixture composition upon melt crystallization because the glass-transition temperatures of the mixtures were much lower than the crystallization temperature of PCL. The radii of the PCL spherulites increased linearly with time at crystallization temperatures ranging from 42 to 498C. The isothermal growth rates of PCL spherulites decreased with the amount of the amorphous PVME components in the mixtures. Accounting for the miscibility of PCL/PVME mixtures, the radial growth rates of PCL spherulites were well described by a kinetic equation involving the Flory-Huggins interaction parameter and the free energy for the nuclei formation in such a way that the theoretical calculations were in good agreement with the experimental data. From the analysis of the equilibrium melting point depression, the interaction energy density of the PVME/PCL system was calculated to be À3.95 J/cm 3 .

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Effects of microtopographic patterns on platelet adhesion and activation on titanium oxide surfaces

Ding¹,

Leng²,

Huang³

et al. 2012

J Biomedical Materials Res

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This study systematically investigated the effects of microtopographic patterns of titanium oxide on platelet adhesion and activation in order to reveal the mechanisms of interactions between platelet and surface topography. Periodic arrays of groove and pillar patterns with dimensions ranging from submicron to several micrometers were fabricated by photolithography and deep reactive-ion etching on silicon substrates, followed by the sputter deposition of titanium oxide (TiO(2)). Platelet adhesion and activation on TiO(2) patterned surfaces were evaluated by lactate dehydrogenase (LDH) and GMP-140 assays, respectively. The morphology of adherent platelets was examined by scanning electron microscope (SEM). The results showed that the microtopographic patterns were able to effectively manipulate the platelet response by varying geometry and size of patterns. A groove pattern resulted in much higher levels of platelet adhesion and activation than a pillar pattern. The study revealed that a difference in pattern size led to two distinctive modes of platelet adhesion: the "bridging" mode in which platelets can bridge over spacing between adjacent patterns when spacing size is smaller than 1.5 μm; and the "full-contact" mode in which platelets cannot bridge but fully contact the entire surface when spacing size is larger than 3 μm. Our analysis indicates good correlations between platelet behavior and hydrophobicity/wetting anisotropy in "bridging" mode, and effective surface contact area in "full-contact" mode.

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Biomedical Applications Polymer Blends

Cited by 11 publications

References 45 publications

Effect of bisphenol A on the miscibility, phase morphology, and specific interaction in immiscible biodegradable poly(ε‐caprolactone)/poly(L‐lactide) blends

Effect of bisphenol A on the miscibility, phase morphology, and specific interaction in immiscible biodegradable poly(ε‐caprolactone)/poly(L‐lactide) blends

Crystallization behavior of poly(ϵ‐caprolactone) in poly(ϵ‐caprolactone) and poly(vinyl methyl ether) mixtures

Effects of microtopographic patterns on platelet adhesion and activation on titanium oxide surfaces

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