Biomedical Applications of Titanium Alloys Modified with MOFs—Current Knowledge and Further Development Directions

Abstract

MOFs (Metal–Organic Frameworks) are so-called coordination polymers with a porous crystalline structure. In this review, the main emphasis was placed on these compounds’ use in modifying titanium implants. The article describes what MOFs are, gives examples of ligands used in the synthesis of MOFs, and describes a subgroup of these materials, i.e., Zeolitic imidazolate frameworks. The article also lists the basic biomedical applications of these compounds. This review shows the significant impact of titanium surface modification with Metal–Organic Frameworks. These modifications make it possible to obtain layers with antibacterial properties, better corrosion resistance, increasing cell proliferation, faster bone growth in vivo, and much more. The presented work shows that the modification of titanium with MOFs is a very promising method of improving their properties. We hope that the prepared review will help research groups from around the world in the preparation of implants modified with Metal–Organic Frameworks with enhanced properties and utility applications.

Zinc‐doped hydroxyapatite as a pH responsive drug delivery system for anticancer drug 6‐mercaptopurine

“…In addition, drug delivery systems should be biocompatible and not release toxic substances. However, MOFs degrade under aqueous conditions and thus release the toxic ligand 18 . In addition, the ideal carrier of anti‐cancer substances should be released only and exclusively in the vicinity of cancer cells.…”

Recent Developments in Multifunctional Coordination Polymers

“…The identification of small or complex organic molecules [27][28][29] and the detection of luminescent polymeric materials [30] have been consistently investigated. Numerous analytical applications have been developed for food components [31] and agricultural products [32], as well as for biomolecules, pharmaceuticals [33,34] and medical investigations [35][36][37][38].…”