Biomedical applications of solid-binding peptides and proteins

One‐Pot Synthesis of Bioinspired Peptide‐Decorated Apatite Nanoparticles for Nanomedicine

“…Beyond this proof of concept, this synthetic strategy allows to access to a family of structurally and functionally well‐defined hybrid peptide apatite NPs as tailorable, multifunctional bioactive nanosystems. From an applicative biomedical viewpoint, [ 46 ] peptide‐functionalized compounds can offer tunable properties in nanomedicine, whether for diagnostics (using fluorescent peptides) and therapeutic (e.g., antibacterial peptides) applications, [ 47 ] for use in bio‐sensing and regenerative medicine. Peptide‐decorated apatite NPs could, e.g., be envisioned in the field of dermatology (e.g., for wound healing) or for bone repair, in combination with a support matrix.…”

Peptide-based self-assembled monolayers (SAMs): what peptides can do for SAMs and vice versa

“…[63][64][65] SBPs are employed to increase the biocompatibility of hybrid materials under physiological conditions, and exhibit tunable properties for the presentation of biomolecular cues with minimum impact on their function as part of biomedical applications, such as drug delivery, biosensing, and regenerative therapies. 66 In the context of peptide-based SAMs, SBPs have been employed for non-covalent surface modification as part of biosensing platforms and dental implants. Their ability to immobilise probes combined with their antifouling protection of metal surfaces against nonspecific adsorption make them suitable candidates for biosensing applications.…”

Towards predictive control of reversible nanoparticle assembly with solid-binding proteins

“…27 However, most are 7 to 12 residues-long sequences selected by combinatorial display techniques for their affinity for a target material. 28 While solid-binding peptides and proteins have been extensively used to study biotic-abiotic interactions, control biomimetic mineralization, and connect inorganic and synthetic components in nanobiotechnology and biomedical applications, 26,[29][30][31][32] their potential to drive colloidal reconfiguration in response to external triggers remains largely unexplored.…”