Biomedical Applications of Silver Nanoparticles

Abstract

Nanotechnology is a branch of science and engineering dedicated to materials, having dimensions in the order of nanometer scale and it has been widely used for the development of more efficient technology. Nanoparticles offer many benefits to bulk particles such as increased surface-to-volume ratio, and increased magnetic properties. In recent years, nanotechnology has been embraced by industrial sectors due to its applications in the field of electronic storage systems, biotechnology, magnetic separation and pre concentration of target analytes, targeted drug delivery, and vehicles for gene and drug delivery. Over the year’s nanomaterials such as nanoparticles, nanoclusters, nanoreods, nanoshells, and nanocages have been continuously used and modified to enable their use as a diagnostic and therapeutic agent in biomedical applications. Thus, In this chapter, introduction to metal nanoparticles, synthesis (Chemical and green synthesis) and biomedical application silver nanoparticles are presented.

Green synthesis of silver nanoparticles (AgNPs) by Lallemantia royleana leaf Extract: Their Bio-Pharmaceutical and catalytic properties

“…Silver nanoparticles (AgNPs) are more and more popular especially in biomedicines because their broad antimicrobial activity is very helpful in the developed drug delivery systems [10]. A possible mode of action of AgNPs is correlated to their hydrophilic -hydrophobic balance and a target specific localized surface resonance (LSR) characteristic, which offers a variety of chances for the drug delivery and modification systems [11,12].…”

The nano-revolution in the diagnosis and treatment of endometriosis

“…[57][58][59] AgNPs can be functionalized with ligand and homing peptides, but also labelled with a fluorophore that makes them brighter by increasing their fluorescence intensity. 57,58,60,61 Thanks to their low cytotoxicity, easy preparation, high stability, biocompatibility, and functionalization, in the work proposed by Simòn-Gracìa, AgNPs were used as tracker in cells and tissues by optical imaging. The AgNPs were synthesized according to the citrate method of Lee and Meisel 62 and functionalized with PL1, that is well internalized by endometriotic immortalized cell lines.…”

Antimicrobial and Cytotoxic Effect of Positively Charged Nanosilver-Coated Silk Sutures

“…Among many other metals, noble metal silver (Ag) is commonly employed and studied owing to its exceptional properties, including high conductivity, chemical stability, and catalytic and antimicrobial capabilities. This makes AgNPs effectively incorporated into various biomedical applications, such as antimicrobial, biosensing, drug delivery, tissue regeneration, implants, dressings, cosmetics, and coatings . AgNPs are known for their remarkable inhibitory and microbial effects on bacteria, fungi, parasites, and viruses .…”

“…This makes AgNPs effectively incorporated into various biomedical applications, such as antimicrobial, biosensing, drug delivery, tissue regeneration, implants, dressings, cosmetics, and coatings. 9 AgNPs are known for their remarkable inhibitory and microbial effects on bacteria, fungi, parasites, and viruses. 10 The broad spectrum of action or mechanism depends on the release of silver ions that produce ROS and toxic agents that can bind to membrane proteins and nucleic acids, causing a cascade of actions, including structural changes, denaturation, and inhibition of replication, leading to cell death.…”