Biomedical Applications of Promising Nanomaterials with Carbon Nanotubes

Gerasimenko, Alexander Yu.; Ичкитидзе, Л. П.; Podgaetsky, Vitaly M.; Селищев, С. В.

doi:10.1007/s10527-015-9476-z

Cited by 31 publications

(22 citation statements)

References 15 publications

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“…The sizes of CNTs are close to the sizes of the main components of the natural cellular matrix, and their mechanical properties are similar to the properties of the protein structures. [18][19][20] To create the composite biostructures, we used single-walled carbon nanotubes (SWCNTs). Nanotubes were synthesized by an arc discharge method using Ni/Y catalyst, then they are cleaned in a mixture of HNO 3 ∕H 2 SO 4 with the following washing until neutral reaction.…”

Section: Methodsmentioning

confidence: 99%

Laser structuring of carbon nanotubes in the albumin matrix for the creation of composite biostructures

et al. 2017

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This paper presents the composite biostructures created by laser structuring of the single-walled carbon nanotubes (SWCNTs) in an albumin matrix. Under the exposure of femtosecond laser radiation, the heating of the albumin aqueous solution causes liquid water to evaporate. As a result, we obtained a solid-state composite in the bulk or film form. Using the molecular dynamic method, we showed the formation of a framework from SWCNTs by the example of splicing of the open end of one nanotube with the defect region of another nanotube under the action of the laser heating. Laser heating of SWCNTs up to a temperature of 80°C to 100°C causes the C ? C bond formation. Raman spectra measured for the composite biostructures allowed us to describe the binding of oxygen atoms of amino acid residues of the albumin with the carbon atoms of the SWCNTs. It is found that the interaction energy of the nanotube atoms and albumin atoms amounts up to 580 ?? kJ / mol . We used atomic force microscopy to investigate the surface of the composite biostructures. The pore size is in the range of 30 to 120 nm. It is proved that the proliferation of the fibroblasts occurred on the surface of the composite biostructures during 72 h of incubation.

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Section: Methodsmentioning

confidence: 99%

Laser structuring of carbon nanotubes in the albumin matrix for the creation of composite biostructures

et al. 2017

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“…Some studies have been undertaken to investigate the use of carbon-based nanomaterials for bone tissue engineering in vivo [4]. The new properties of carbon materials such as fullerene, CNT, and graphene have significantly increased their study and applications [5,6]. Due to their unique properties and high mechanical strength, they have been widely used to reinforce materials with biomedical applications and for tissue regeneration [7].…”

Section: Introductionmentioning

confidence: 99%

Nanocomposite Films of Chitosan-Grafted Carbon Nano-Onions for Biomedical Applications

et al. 2020

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The design of scaffolding from biocompatible and resistant materials such as carbon nanomaterials and biopolymers has become very important, given the high rate of injured patients. Graphene and carbon nanotubes, for example, have been used to improve the physical, mechanical, and biological properties of different materials and devices. In this work, we report the grafting of carbon nano-onions with chitosan (CS-g-CNO) through an amide-type bond. These compounds were blended with chitosan and polyvinyl alcohol composites to produce films for subdermal implantation in Wistar rats. Films with physical mixture between chitosan, polyvinyl alcohol, and carbon nano-onions were also prepared for comparison purposes. Film characterization was performed with Fourier Transformation Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), Differential Scanning Calorimetry (DSC), Tensile strength, X-ray Diffraction Spectroscopy (XRD), and Scanning Electron Microscopy (SEM). The degradation of films into simulated body fluid (SBF) showed losses between 14% and 16% of the initial weight after 25 days of treatment. Still, a faster degradation (weight loss and pH changes) was obtained with composites of CS-g-CNO due to a higher SBF interaction by hydrogen bonding. On the other hand, in vivo evaluation of nanocomposites during 30 days in Wistar rats, subdermal tissue demonstrated normal resorption of the materials with lower inflammation processes as compared with the physical blends of ox-CNO formulations. SBF hydrolytic results agreed with the in vivo degradation for all samples, demonstrating that with a higher ox-CNO content increased the stability of the material and decreased its degradation capacity; however, we observed greater reabsorption with the formulations including CS-g-CNO. With this research, we demonstrated the future impact of CS/PVA/CS-g-CNO nanocomposite films for biomedical applications.

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“…It is known that CNTs can adsorb extracellular and serum proteins and improve interaction with cell cultures due to their high bioactivity and biocompatibility [10]. Unique electronic properties of CNTs are used to create biocompatible materials with high electrical conductivity [11,12]. The framework of such materials is a branched CNT network, and the filler is one of the proteins or a protein complex.…”

Section: Introductionmentioning

confidence: 99%

“…However, the main problem of such biomaterials is the reduction of the mass fraction of CNTs, so that the material is not toxic, without loss of high electrical conductivity [11]. One way to solve this problem is to optimize the junctions between CNTs, which should provide the minimum possible contact resistance [17].…”

Section: Introductionmentioning

confidence: 99%

“…One of the interesting and common junctions between CNTs in branched networks is the T-junction. Such networks are already widely synthesized [31,32] and are used to produce biocompatible composite materials for medical purposes and tissue engineering [11]. The electrical conductivity of biomaterials with such CNT networks can be quite high [32].…”

Section: Introductionmentioning

confidence: 99%

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Specific Features of Structure, Electrical Conductivity and Interlayer Adhesion of the Natural Polymer Matrix from the Layers of Branched Carbon Nanotube Networks Filled with Albumin, Collagen and Chitosan

et al. 2018

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This paper considers the problem of creating a conductive matrix with a framework made of carbon nanotubes (CNTs) for cell and tissue engineering. In silico investigation of the electrical conductivity of the framework formed by T-junctions of single-walled carbon nanotubes (SWNTs) (12, 12) with a diameter of 1.5 nm has been carried out. A numerical evaluation of the contact resistance and electrical conductivity of seamless and suture T-junctions of SWCNTs is given. The effect of the type of structural defects in the contact area of the tubes on the contact resistance of the T-junction of SWCNTs was revealed. A coarse-grained model of a branched SWCNT network with different structure densities is constructed and its electrical conductivity is calculated. A new layered bioconstruction is proposed, the layers of which are formed by natural polymer matrixes: CNT-collagen, CNT-albumin and CNT-chitosan. The energy stability of the layered natural polymer matrix has been analyzed, and the adhesion of various layers to each other has been calculated. Based on the obtained results, a new approach has been developed in the formation of 3D electrically conductive bioengineering structures for the restoration of cell activity.

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Biomedical Applications of Promising Nanomaterials with Carbon Nanotubes

Cited by 31 publications

References 15 publications

Laser structuring of carbon nanotubes in the albumin matrix for the creation of composite biostructures

Laser structuring of carbon nanotubes in the albumin matrix for the creation of composite biostructures

Nanocomposite Films of Chitosan-Grafted Carbon Nano-Onions for Biomedical Applications

Specific Features of Structure, Electrical Conductivity and Interlayer Adhesion of the Natural Polymer Matrix from the Layers of Branched Carbon Nanotube Networks Filled with Albumin, Collagen and Chitosan

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