Biomedical Applications of Polylactide (PLA) and Its Copolymers

Giammona, Gaetano; Craparo, Emanuela Fabiola

doi:10.3390/molecules23040980

Cited by 24 publications

(15 citation statements)

References 9 publications

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“…Among other filaments, FDM technology allows for additive manufacturing of biopolymers such as lignin and polylactides (PLA), a biodegradable filament used for tissue engineering purposes in various fields of regenerative medicine and dentistry [24][25][26]. Despite environmental advantage in terms of biodegradability, recent studies showed improvements of the mechanical properties by changing the layups of the fibers of subsequent layers [20].…”

Section: Introductionmentioning

confidence: 99%

How Accurate Is Oral Implant Installation Using Surgical Guides Printed from a Degradable and Steam-Sterilized Biopolymer?

Pieralli

Spies

Hromadnik

et al. 2020

JCM

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3D printed surgical guides are used for prosthetically-driven oral implant placement. When manufacturing these guides, information regarding suitable printing techniques and materials as well as the necessity for additional, non-printed stock parts such as metal sleeves is scarce. The aim of the investigation was to determine the accuracy of a surgical workflow for oral implant placement using guides manufactured by means of fused deposition modeling (FDM) from a biodegradable and sterilizable biopolymer filament. Furthermore, the potential benefit of metal sleeve inserts should be assessed. A surgical guide was designed for the installation of two implants in the region of the second premolar (SP) and second molar (SM) in a mandibular typodont model. For two additive manufacturing techniques (stereolithography [SLA]: reference group, FDM: observational group) n = 10 surgical guides, with (S) and without (NS) metal sleeves, were used. This resulted in 4 groups of 10 samples each (SLA-S/NS, FDM-S/NS). Target and real implant positions were superimposed and compared using a dedicated software. Sagittal, transversal, and vertical discrepancies at the level of the implant shoulder, apex and regarding the main axis were determined. MANOVA with posthoc Tukey tests were performed for statistical analyses. Placed implants showed sagittal and transversal discrepancies of <1 mm, vertical discrepancies of <0.6 mm, and axial deviations of ≤3°. In the vertical dimension, no differences between the four groups were measured (p ≤ 0.054). In the sagittal dimension, SLA groups showed decreased deviations in the implant shoulder region compared to FDM (p ≤ 0.033), whereas no differences in the transversal dimension between the groups were measured (p ≤ 0.054). The use of metal sleeves did not affect axial, vertical, and sagittal accuracy, but resulted in increased transversal deviations (p = 0.001). Regarding accuracy, biopolymer-based surgical guides manufactured by means of FDM present similar accuracy than SLA. Cytotoxicity tests are necessary to confirm their biocompatibility in the oral environment.

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Section: Introductionmentioning

confidence: 99%

How Accurate Is Oral Implant Installation Using Surgical Guides Printed from a Degradable and Steam-Sterilized Biopolymer?

Pieralli

Spies

Hromadnik

et al. 2020

JCM

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“…Incorporating two monomers with different physicochemical properties in one copolymer is of great interest, especially for biomedical applications. Copolymerization brings the advantages and properties of both monomers into one macromolecular structure, and several copolymers have already been synthesized and used for biomedical applications [ 28 , 36 , 37 , 38 , 51 , 52 , 53 , 54 ]. Since we have previously shown the effectiveness of the 1-pyreneacetic acid/P 4 - t -Bu initiator/base system for the homopolymerization of both diMeMLABn & diMeMLAHe, the same initiator/base system has been selected to polymerize sequentially diMeMLAHe and diMeMLABn in two ratios allowing to modulate the hydrophobic/hydrophilic balance of the final amphiphilic block copolymers ( Scheme 4 ).…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Poly(Dimethylmalic Acid) Homo- and Copolymers to Produce Biodegradable Nanoparticles for Drug Delivery: Cell Uptake and Biocompatibility Evaluation in Human Heparg Hepatoma Cells

Khalil

Saba²,

Ribault³

et al. 2020

Polymers

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Hydrophobic and amphiphilic derivatives of the biocompatible and biodegradable poly(dimethylmalic acid) (PdiMeMLA), varying by the nature of the lateral chains and the length of each block, respectively, have been synthesized by anionic ring-opening polymerization (aROP) of the corresponding monomers using an initiator/base system, which allowed for very good control over the (co)polymers’ characteristics (molar masses, dispersity, nature of end-chains). Hydrophobic and core-shell nanoparticles (NPs) were then prepared by nanoprecipitation of hydrophobic homopolymers and amphiphilic block copolymers, respectively. Negatively charged NPs, showing hydrodynamic diameters (Dh) between 50 and 130 nm and narrow size distributions (0.08 < PDI < 0.22) depending on the (co)polymers nature, were obtained and characterized by dynamic light scattering (DLS), zetametry, and transmission electron microscopy (TEM). Finally, the cytotoxicity and cellular uptake of the obtained NPs were evaluated in vitro using the hepatoma HepaRG cell line. Our results showed that both cytotoxicity and cellular uptake were influenced by the nature of the (co)polymer constituting the NPs.

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“…in which X is the OD 600 value, which describes the biomass concentration, μ m is the maximum specific growth rate (h −1 ), and X m is the maximum OD 600 . l-Lactic acid production was described by the Luedeking-Piret function [20] = + (2) in which P is the l-lactic acid concentration (g/L), α is a growth-associated constant, and β is a non-growthassociated constant.…”

Section: Kinetic Modelsmentioning

confidence: 99%

“…In recent years, the urgent need to reduce environmental pollution caused by plastics has driven the development of biodegradable green plastics. Polylactic acid (PLA), a type of environmentally friendly plastic, has attracted unprecedented global attention owing to its biodegradable and biocompatible properties; it has the potential to replace traditional plastics produced by petroleum fuels [1][2][3]. Some properties of PLA, including its crystallinity, thermal stability and hydrolysis resistance, are affected by the relative fractions of l-and d-isomers in polymer chains [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Kinetic characteristics of long‐term repeated fed‐batch (LtRFb) l‐lactic acid fermentation by a Bacillus coagulans strain

Zhang

Liu

Xiao

et al. 2020

Engineering in Life Sciences

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Application of degradable plastics is the most critical solution to plastic pollution. As the precursor of biodegradable plastic PLA (polylactic acid), efficient production of l-lactic acid is vital for the commercial replacement of traditional plastics. Bacillus coagulans H-2, a robust strain, was investigated for effective production of l-lactic acid using long-term repeated fed-batch (LtRFb) fermentation. Kinetic characteristics of l-lactic acid fermentation were analyzed by two models, showing that cell-growth coupled production gradually replaces cellmaintenance coupled production during fermentation. With the LtRFb strategy, l-lactic acid was produced at a high final concentration of 192.7 g/L, on average, and a yield of up to 93.0% during 20 batches of repeated fermentation within 487.5 h. Thus, strain H-2 can be used in the industrial production of l-lactic acid with optimization based on kinetic modeling.

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Biomedical Applications of Polylactide (PLA) and Its Copolymers

Abstract: n/a

Cited by 24 publications

References 9 publications

How Accurate Is Oral Implant Installation Using Surgical Guides Printed from a Degradable and Steam-Sterilized Biopolymer?

How Accurate Is Oral Implant Installation Using Surgical Guides Printed from a Degradable and Steam-Sterilized Biopolymer?

Synthesis of Poly(Dimethylmalic Acid) Homo- and Copolymers to Produce Biodegradable Nanoparticles for Drug Delivery: Cell Uptake and Biocompatibility Evaluation in Human Heparg Hepatoma Cells

Kinetic characteristics of long‐term repeated fed‐batch (LtRFb) l‐lactic acid fermentation by a Bacillus coagulans strain

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