Biomedical applications of plasma polymerization and plasma treatment of polymer surfaces

Yasuda, H.; Gazicki, M.

doi:10.1016/0142-9612(82)90036-9

Cited by 214 publications

(83 citation statements)

References 9 publications

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“…Plasma action is limited to the 10 nmthick surface layer and does not affect the bulk of the material. [5][6][7][8][9][10] The physical effects of plasma include surface cleaning (removing low-molecular components that have migrated to the surface), etching, smoothing or roughening, whereas chemical surface modification may involve crosslinking, branching, activation, and attachment of chemical groups. Depending on the treatment conditions such as type of gas, Figure 6.…”

Section: Discussionmentioning

confidence: 99%

“…The main outcome of plasma treatment is surface cleaning, microetching, and surface activation (attachment of chemical groups, modification of surface charge, increasing the surface's free energy, enhancing wettability). [5][6][7][8][9][10] In recent years, porous scaffolds from poly(L/DLlactide) 80/20%, mainly microporous membranes and sponges, have been used to treat critical-size bone defects [11][12][13][14][15] and to culture osteogenic cells, 16,17 chondrocytes, 18 and fibroblasts. 19 It has been found that these scaffolds facilitate bone regeneration and support attachment, growth, and activity of cells.…”

Section: Introductionmentioning

confidence: 99%

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Attachment, growth, and activity of rat osteoblasts on polylactide membranes treated with various low‐temperature radiofrequency plasmas

Gugala

Gogolewski

2005

J Biomedical Materials Res

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Nonporous and porous membranes from poly(L/DL-lactide) 80/20% were treated with low-temperature oxygen, ammonia, or sulphur dioxide-hydrogen plasmas and the late effects of plasma treatment on physicochemical characteristics of the membranes' surface were analyzed. The plasma treatment resulted in the permanent attachment of sulphur and nitrogen functionalities to the membrane's surface, and increased the surface concentration of oxygen, thereby increasing the surface wettability. To assess whether the plasma treatment affects the cellular response, primary rat osteoblasts were cultured on nontreated and plasma-treated nonporous and microporous membranes, and attachment, growth, and activity of cells were investigated. It was found that attachment and growth of osteoblasts on all the plasma-treated membranes were greater compared with nontreated controls. The treatment with ammonia plasma was most efficacious. The beneficial effects of plasma treatment on cells were most pronounced for microporous polylactide membranes irrespective of the plasma used. The results of the study suggest that the treatment of porous polylactide structures with plasma can be an effective means of enhancing their suitability for tissue engineering. Plasma exposure may also have an advantageous effect on bone healing when polylactide membranes are used to treat bone defects.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Attachment, growth, and activity of rat osteoblasts on polylactide membranes treated with various low‐temperature radiofrequency plasmas

Gugala

Gogolewski

2005

J Biomedical Materials Res

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“…Other surface modification approaches include deposition of glow-discharge polymers such as hexamethyldisil'oxane or tetrafluoroethylene [151][152][153][154][155]. The radiofrequency glow discharge treatment of some polymers, results in a dramatic improvement in patency, studied in the ex vivo femoral shunt model [153], although it is not clear if this also improves the long-term in vivo patency.…”

Section: Polymer Surface Modification and Blood Compatibilitymentioning

confidence: 99%

Selected topics in biomedical polyurethanes. A review

Gogolewski

1989

Colloid & Polymer Sci

222

140

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“…[1][2][3][4] The use of plasma for controlled surface modifications of various substrate materials has advanced rapidly over the last few decades and continues to grow. [5][6][7] However, there is still a lack of understanding of the chemical and physical properties required of a particular substrate material (be that organic or inorganic) to ensure an optimal coating with a plasma polymer film of choice is stable and adherent. Therefore, study of the interface region that forms between a substrate and its plasma polymer are of particular interest.…”

Section: Introductionmentioning

confidence: 99%

Probing the Interfacial Structure of Bilayer Plasma Polymer Films via Neutron Reflectometry

Nelson

Easton

et al. 2015

Plasma Process. Polym.

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Bilayer plasma polymer (PP) films were examined using a combination of X-ray and neutron reflectometery and X-ray photoelectron spectroscopy to gain an understanding of the interfacial structures that form between the films. Three different PP films were produced from the monomers hexamethyldisiloxane (HMDSO), di(ethylene glycol) dimethyl ether (DG), and allylamine (AA) at different load powers. These films were used as ''substrates'' for the subsequent deposition of a deuterated DG (dDG) PP top film. The width of the interfacial region was found to be strongly dependent on the chemical and physical properties of the substrate film. These findings have relevance to the general use and application of plasma polymer films.

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Biomedical applications of plasma polymerization and plasma treatment of polymer surfaces

Cited by 214 publications

References 9 publications

Attachment, growth, and activity of rat osteoblasts on polylactide membranes treated with various low‐temperature radiofrequency plasmas

Attachment, growth, and activity of rat osteoblasts on polylactide membranes treated with various low‐temperature radiofrequency plasmas

Selected topics in biomedical polyurethanes. A review

Probing the Interfacial Structure of Bilayer Plasma Polymer Films via Neutron Reflectometry

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