Biomedical applications of multifunctional magnetoelectric nanoparticles

Apu, Ehsanul Hoque; Nafiujjaman, Md; Sandeep, Srikumar; Makela, Ashley V.; Khaleghi, Ali; Vainio, Seppo; Contag, Christopher H.; Li, Jinxing; Balasingham, Ilangko; Kim, Taeho; Ashammakhi, Nureddin

doi:10.1039/d2qm00093h

Cited by 16 publications

(4 citation statements)

References 143 publications

(288 reference statements)

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“…For magneto-myography (MMG), Zuo et al simulated and developed, as an alternative to a SQUID, a magneto-electric sensor which enabled the measuring of pT MMG signals [176]. Apu et al described the potential use of magneto-electric nanoparticles in drug delivery, bio-imaging, neural stimulation and other biomedical applications [177]. Combining energy harvesting and sensing with a magneto-electric antenna, Das et al modeled such a hybrid antenna as a potential neural implant [178].…”

Section: Other Magnetic Effects and Sensors For Health Monitoringmentioning

confidence: 99%

Magnetic Micro and Nano Sensors for Continuous Health Monitoring

Blachowicz,

Kola,

Ehrmann

et al. 2024

Micro

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Magnetic micro and nano sensors can be used in a broad variety of applications, e.g., for navigation, automotives, smartphones and also for health monitoring. Based on physical effects such as the well-known magnetic induction, the Hall effect, tunnel magnetoresistance and giant magnetoresistance, they can be used to measure positions, flow, pressure and other physical properties. In biomedicine and healthcare, these miniaturized sensors can be either integrated into garments and other wearables, be directed through the body by passive capsules or active micro-robots or be implanted, which usually necessitates bio-functionalization and avoiding cell-toxic materials. This review describes the physical effects that can be applied in these sensors and discusses the most recent micro and nano sensors developed for healthcare applications.

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Section: Other Magnetic Effects and Sensors For Health Monitoringmentioning

confidence: 99%

Magnetic Micro and Nano Sensors for Continuous Health Monitoring

Blachowicz,

Kola,

Ehrmann

et al. 2024

Micro

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“…As a potential solution, lead-free magnetoelectric nanoparticles (MENs) have been explored for biocompatible wireless stimulations within deep tissues, including brain stimulations. [27] However, prevalent approach involves direct injection of MENs with a dosage corresponding to the body weight of an animal, [28,29] elevating the risk of inessential overdosing that could compromise the ability of MENs to precisely stimulate localized areas owing to their nanoscale and potentially induce long-term cytotoxic effects. Therefore, ensuring controlled and targeted delivery of MENs to specific body sites remains a challenge.…”

Section: Introductionmentioning

confidence: 99%

Flexible, Biodegradable, and Wireless Magnetoelectric Paper for Simple In Situ Personalization of Bioelectric Implants

Choe,

Kim,

Lee

et al. 2024

Advanced Materials

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Bioelectronic implants delivering electrical stimulation offer an attractive alternative to traditional pharmaceuticals in electrotherapy. However, achieving simple, rapid, and cost‐effective personalization of these implants for customized treatment in unique clinical and physical scenarios presents a substantial challenge. This challenge is further compounded by the need to ensure safety and minimal invasiveness, requiring essential attributes such as flexibility, biocompatibility, lightness, biodegradability, and wireless stimulation capability. Here, we introduce a flexible, biodegradable bioelectronic paper with homogeneously distributed wireless stimulation functionality for simple personalization of bioelectronic implants. The bioelectronic paper synergistically combines (i) lead‐free magnetoelectric nanoparticles (MENs) that facilitate electrical stimulation in response to external magnetic field and (ii) flexible and biodegradable nanofibers (NFs) that enable localization of MENs for high‐selectivity stimulation, oxygen/nutrient permeation, cell orientation modulation, and biodegradation rate control. We show the effectiveness of wireless electrical stimulation in vitro through enhanced neuronal differentiation of neuron‐like PC12 cells and the controllability of their microstructural orientation. Also, we show scalability, design flexibility, and rapid customizability of the bioelectronic paper by creating various 3D macrostructures using simple paper crafting techniques such as cutting and folding. This platform holds promise for simple and rapid personalization of temporary bioelectronic implants for minimally invasive wireless stimulation therapies.This article is protected by copyright. All rights reserved

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“…Magnetic particles have been found to be favorably responsive towards lungs cancer cells [ 13 ], red blood cells [ 14 , 15 ], and urological cancer cells [ 16 , 17 ]. These MNPs are valuable in the field of life sciences, such as bio-imaging, bio-sensing, and drug administration systems, due to their good magnetic properties, low toxicity, and small diameter [ 18 , 19 ]. The use of hyperthermia in cancer therapy has expanded significantly.…”

Section: Introductionmentioning

confidence: 99%

Cobalt Iron Oxide (CoFe2O4) Nanoparticles Induced Toxicity in Rabbits

Khan

Buzdar

Hussain

et al. 2023

Veterinary Sciences

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The market for nanoparticles has grown significantly over the past few decades due to a number of unique qualities, including antibacterial capabilities. It is still unclear how nanoparticle toxicity works. In order to ascertain the toxicity of synthetic cobalt iron oxide (CoFe2O4) nanoparticles (CIONPs) in rabbits, this study was carried out. Sixteen rabbits in total were purchased from the neighborhood market and divided into two groups (A and B), each of which contained eight rabbits. The CIONPs were synthesized by the co-precipitation method. Crystallinity and phase identification were confirmed by X-ray diffraction (XRD). The average size of the nanoparticles (13.2 nm) was calculated by Scherrer formula (Dhkl = 0.9 λ/β cos θ) and confirmed by TEM images. The saturation magnetization, 50.1 emug−1, was measured by vibrating sample magnetometer (VSM). CIONPs were investigated as contrast agents (CA) for magnetic resonance images (MRI). The relaxivity (r = 1/T) of the MRI was also investigated at a field strength of 0.35 T (Tesla), and the ratio r2/r1 for the CIONPs contrast agent was 6.63. The CIONPs were administrated intravenously into the rabbits through the ear vein. Blood was collected at days 5 and 10 post-exposure for hematological and serum biochemistry analyses. The intensities of the signal experienced by CA with CIONPs were 1427 for the liver and 1702 for the spleen. The treated group showed significantly lower hematological parameters, but significantly higher total white blood cell counts and neutrophils. The results of the serum biochemistry analyses showed significantly higher and lower quantities of different serum biochemical parameters in the treated rabbits at day 10 of the trial. At the microscopic level, different histological ailments were observed in the visceral organs of treated rabbits, including the liver, kidneys, spleen, heart, and brain. In conclusion, the results revealed that cobalt iron oxide (CoFe2O4) nanoparticles induced toxicity via alterations in multiple tissues of rabbits.

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Biomedical applications of multifunctional magnetoelectric nanoparticles

Abstract: Advances in nanotechnology are impacting biomedicine with the potential to improve disease diagnosis, enhance targeted drug delivery, refine imaging of therapeutic responses, control cell and tissue responses, and guide resection....

Cited by 16 publications

References 143 publications

Magnetic Micro and Nano Sensors for Continuous Health Monitoring

Magnetic Micro and Nano Sensors for Continuous Health Monitoring

Flexible, Biodegradable, and Wireless Magnetoelectric Paper for Simple In Situ Personalization of Bioelectric Implants

Cobalt Iron Oxide (CoFe2O4) Nanoparticles Induced Toxicity in Rabbits

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