Biomedical applications of magneto-responsive scaffolds

Adedoyin, Adedokun A.; Ekenseair, Adam K.

doi:10.1007/s12274-018-2198-2

Cited by 77 publications

(72 citation statements)

References 90 publications

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“…Nanotechnologies aim to ease and to satisfy the needs of regenerative medicine 1 by providing multifunctional, theranostic, and stimuli-responsive biomaterials [1,2]. In particular, stimuli-responsive biomaterials such as magneto-responsive biomaterials are devices capable of reacting to an external magnetic field spatiotemporally in a specific way [3].…”

Section: Introductionmentioning

confidence: 99%

Biomedical Applications of Biomaterials Functionalized with Magnetic Nanoparticles

Lodi¹,

Fanti²

2020

Smart Nanosystems for Biomedicine, Optoelectronics and Catalysis

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The combination of magnetic nanoparticles and a biocompatible material leads to the manufacturing of a multifunctional and remotely controlled platform useful for diverse biomedical issues. If a static magnetic field is applied, a magnetic scaffold behaves like an attraction platform for magnetic carriers of growth factors, thus being a potential tool to enhance magnetic drug delivery in regenerative medicine. To translate in practice this potential application, a careful and critical description of the physics and the influence parameter is required. This chapter covers the mathematical modeling of the process and assesses the problem of establishing the influence of the drug delivery system on tissue regeneration. On the other hand, if a time-varying magnetic field is applied, the magnetic nanoparticles would dissipate heat, which can be exploited to perform local hyperthermia treatment on residual cancer cells in the bone tissue. To perform the treatment planning, it is necessary to account for the modeling of the intrinsic nonlinear nature of the heat dissipation dynamic in magnetic prosthetic implants. In this work, numeric experiments to investigate the physiopathological features of the biological system, linked to the properties of the nanocomposite magnetic material, to assess its effectiveness as therapeutic agents are presented.

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Section: Introductionmentioning

confidence: 99%

Biomedical Applications of Biomaterials Functionalized with Magnetic Nanoparticles

Lodi¹,

Fanti²

2020

Smart Nanosystems for Biomedicine, Optoelectronics and Catalysis

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show abstract

Section: Introductionmentioning

confidence: 99%

“…In the area of tissue engineering, the controlled release of therapeutics (growth factors, anti‐inflammatory agents, or pain killers), is also highly needed . However, another emerging strategy is the possibility of remotely activating by external fields, tissue actuation for bone, cardiac, neuronal, or muscle regeneration which should result in very attractive applications . Other emerging applications for which nanotechnology hold great promises also concerns the development of integrated systems or devices releasing antimicrobial agents to fight against biofilm formation at implant surface or insulin for glucose regulation in the case of diabetes, where an implanted biomaterial would be more convenient than injection .…”

Section: Introductionmentioning

confidence: 99%

“…The design of smart and remotely responsive nanocomposite scaffolds emerged this last decade as a powerful strategy for applications in nanomedicine, biomaterials, and tissue engineering. [1][2][3][4] For instance, in some antitumoral treatments, important advantages are highlighted in the use of implants as alternatives to circulating nanomaterials. [5] Indeed, by achieving a sustained delivery of therapeutics to a specific diseased tissue, these implants can ensure a local delivery of antitumor drugs to fight cancer, with an optimized dose and minimum loss of drugs administered avoiding side effects.…”

Section: Introductionmentioning

confidence: 99%

“…[4,6,7] However, another emerging strategy is the possibility of remotely activating by external fields, tissue actuation for Dr. D. Mertz The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adtp.201900143 DOI: 10.1002/adtp.201900143 bone, cardiac, neuronal, or muscle regeneration which should result in very attractive applications. [1][2][3]8,9] Other emerging applications for which nanotechnology hold great promises also concerns the development of integrated systems or devices releasing antimicrobial agents to fight against biofilm formation at implant surface [10] or insulin for glucose regulation in the case of diabetes, where an implanted biomaterial would be more convenient than injection. [11,12] Hence, the development of smart new implants, remotely controlled by the application of external fields could be very attractive to treat these diseases.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Nanocomposite Polymer Scaffolds Responding under External Stimuli for Drug Delivery and Tissue Engineering Applications

Mertz

Harlepp

Goetz

et al. 2019

Advanced Therapeutics

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The blossoming development of nanomaterials and polymer science has opened the way toward new biocompatible scaffolds responding remotely to external stimuli (magnetic field, light, electric field). Such smart scaffolds are envisioned as new implantable tissues displaying multiple therapeutic and imaging functionalities. They hold great promises to achieve a controlled delivery of therapeutics for various diseases, or to ensure a stimuli‐induced cellular response for bone, cardiac, or muscle tissue engineering.

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Iron‐Chelated Silk Microfibers as a Novel Magneto‐Responsive Architecture for In Situ Aligning Biomaterial Scaffolds

Wojnowski,

Martin,

Kanber

et al. 2023

Adv Funct Materials

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Magnetically functionalized biomaterials represent an exciting prospect in the development of stimuli‐responsive tissue engineering scaffolds. Magneto‐responsive properties are traditionally imparted to scaffold systems via integration of iron oxide‐based magnetic nanoparticles (MNPs), yet poor understanding of long‐term MNP toxicity presents a significant translational challenge. Given the demonstrated iron‐binding capacity of silk fibroin (SF), passive chelation of ferric iron ions is explored herein as an alternative, MNP‐free approach for magnetic functionalization of silk fibroin (SF)‐based biomaterials. SF microfibers treated with aqueous ferric chloride (FeCl3) exhibit significantly increased iron content relative to the nascent protein. Coupled with the absence of detectable chlorine traces and inorganic iron oxide species, the ferric oxidation state of the iron detected within the FeCl3‐treated microfibers suggests that iron is incorporated, without reduction, at innate oxygen‐containing ligands in SF. On exposure to an external magnetic field, these ferric iron‐chelated SF microfibers (Fe3+‐mSF) display paramagnetic magnetization behaviors that facilitate field‐parallel alignment. Both magnetization and directional uniformity increase with iron exposure during FeCl3 treatment, suggesting the observed magnetic response of Fe3+‐mSF is derived from the chelated iron. This work is the first to investigate the magneto‐responsive properties and biocompatibility of ferric iron‐chelated SF, highlighting a novel, MNP‐free mechanism for synthesizing magnetically functionalizedscaffolds.

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Biomedical applications of magneto-responsive scaffolds

Cited by 77 publications

References 90 publications

Biomedical Applications of Biomaterials Functionalized with Magnetic Nanoparticles

Biomedical Applications of Biomaterials Functionalized with Magnetic Nanoparticles

Nanocomposite Polymer Scaffolds Responding under External Stimuli for Drug Delivery and Tissue Engineering Applications

Iron‐Chelated Silk Microfibers as a Novel Magneto‐Responsive Architecture for In Situ Aligning Biomaterial Scaffolds

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