Biomedical Applications of Lactoferrin on the Ocular Surface

Regueiro, Uxía; López-López, Maite; Varela-Fernández, Rubén; Otero-Espinar, Francisco J.; Lema, M

doi:10.3390/pharmaceutics15030865

Cited by 7 publications

(4 citation statements)

References 154 publications

(235 reference statements)

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“…LF’s therapeutic effects include mitigating CECs damage and promoting cellular repair, as demonstrated in animal models of DED ( Pattamatta et al, 2013 ; Regueiro et al, 2023 ). Connell et al (2021) also observed that LF can increase tear secretion, inhibit the expression of inflammatory factors, and induce a short-lasting effect on tear secretion by modulating the gut microbiota to stimulate the production of short-chain FAs in a mouse model of DED.…”

Section: Impact Of Nutrients On the Ocular Surface And Potential Risksmentioning

confidence: 99%

Recommendations for nutritional supplements for dry eye disease: current advances

Cong,

Zhang,

Han

et al. 2024

Front. Pharmacol.

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Dry eye disease (DED) represents a prevalent ocular surface disease. The development of effective nutritional management strategies for DED is crucial due to its association with various factors such as inflammation, oxidative stress, deficiencies in polyunsaturated fatty acids (PUFAs), imbalanced PUFA ratios, and vitamin insufficiencies. Extensive research has explored the impact of oral nutritional supplements, varying in composition and dosage, on the symptoms of DED. The main components of these supplements include fish oils (Omega-3 fatty acids), vitamins, trace elements, and phytochemical extracts. Beyond these well-known nutrients, it is necessary to explore whether novel nutrients might contribute to more effective DED management. This review provides a comprehensive update on the therapeutic potential of nutrients and presents new perspectives for combination supplements in DED treatment.

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Section: Impact Of Nutrients On the Ocular Surface And Potential Risksmentioning

confidence: 99%

Recommendations for nutritional supplements for dry eye disease: current advances

Cong,

Zhang,

Han

et al. 2024

Front. Pharmacol.

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“…Despite the strong interest in clinical applications of Lf, there are just a few comprehensive clinical studies on topical, ophthalmic Lf formulations [ 92 ] ( Table 2 ).…”

Section: Strategies For Ocular Delivery Of Lfmentioning

confidence: 99%

Development, Optimization, and Clinical Relevance of Lactoferrin Delivery Systems: A Focus on Ocular Delivery

Ponzini,

Astolfi,

Grandori

et al. 2024

Pharmaceutics

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Lactoferrin (Lf), a multifunctional protein found abundantly in secretions, including tears, plays a crucial role in ocular health through its antimicrobial, immunoregulatory, anti-inflammatory, and antioxidant activities. Advanced delivery systems are desirable to fully leverage its therapeutic potential in treating ocular diseases. The process of Lf quantification for diagnostic purposes underscores the importance of developing reliable, cost-effective detection methods, ranging from conventional techniques to advanced nano-based sensors. Despite the ease and non-invasiveness of topical administration for ocular surface diseases, challenges such as rapid drug elimination necessitate innovations, such as Lf-loaded contact lenses and biodegradable polymeric nanocapsules, to enhance drug stability and bioavailability. Furthermore, overcoming ocular barriers for the treatment of posterior segment disease calls for nano-formulations. The scope of this review is to underline the advancements in nanotechnology-based Lf delivery methods, emphasizing the pivotal role of multidisciplinary approaches and cross-field strategies in improving ocular drug delivery and achieving better therapeutic outcomes for a wide spectrum of eye conditions.

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“…Lactoferrin possesses immunomodulatory, anti-inflammatory, antioxidant, antiviral, antimicrobial and anticancerogenic activities. Lately, various technologies have been developed to advance the lactoferrin's role in the ocular drug bioavailability (Figure 6) [58]. 2.1.9.…”

Section: Lactoferrinmentioning

confidence: 99%

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

Chelu,

Musuc

2023

Processes

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Biomaterials are mostly any natural and synthetic materials which are compatible from a biological point of view with the human body. Biomaterials are widely used to sustain, increase, reestablish or substitute the biological function of any injured tissue and organ from the human body. Additionally, biomaterials are uninterruptedly in contact with the human body, i.e., tissue, blood and biological fluids. For this reason, an essential feature of biomaterials is their biocompatibility. Consequently, this review summarizes the classification of different types of biomaterials based on their origin, as natural and synthetic ones. Moreover, the advanced applications in pharmaceutical and medical domains are highlighted based on the specific mechanical and physical properties of biomaterials, concerning their use. The high-priority challenges in the field of biomaterials are also discussed, especially those regarding the transfer and implementation of valuable scientific results in medical practice.

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Biomedical Applications of Lactoferrin on the Ocular Surface

Cited by 7 publications

References 154 publications

Recommendations for nutritional supplements for dry eye disease: current advances

Recommendations for nutritional supplements for dry eye disease: current advances

Development, Optimization, and Clinical Relevance of Lactoferrin Delivery Systems: A Focus on Ocular Delivery

Advanced Biomedical Applications of Multifunctional Natural and Synthetic Biomaterials

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