Biomedical application of aggregation-induced emission luminogen-based fluorescent sensors

Duo, Yanhong; Xiang, Zhongyuan; Gao, Ge; Luo, Guanghong; Tang, Ben Zhong

doi:10.1016/j.trac.2023.117252

Cited by 9 publications

(6 citation statements)

References 254 publications

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“…Reversible binding was confirmed by alternating Cu 2+ and GSH additions, which respectively quenched and restored fluorescence (Figure B). TPEs samples, soft yellow and pale-orange solids, exhibit distinct emissions from TPEs–Cu 2+ complexes, likely as a result of copper interfering with the π–π* transitions of the TPE moiety (Figure C) . Finally, we explored practical applications using filter paper strips dipped in TPEs solutions.…”

Section: Resultsmentioning

confidence: 99%

“…This explains the strong reversible interaction of GSH with copper in the probes–copper complex . In addition to the importance of specific detection of Cu 2+ ions and GSH, aggregation-induced emission (AIE) is a technologically important and remarkable phenomenon that has received much attention since the beginning of the century . It is particularly useful for the specific detection of ions, which is a crucial area of research.…”

Section: Introductionmentioning

confidence: 99%

“… 32 In addition to the importance of specific detection of Cu 2+ ions and GSH, aggregation-induced emission (AIE) is a technologically important and remarkable phenomenon that has received much attention since the beginning of the century. 33 It is particularly useful for the specific detection of ions, which is a crucial area of research. In this context, tetraphenylethene (TPE) is an effective fluorophore that exhibits AIE.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of Phenol-Hydrazide-Appended Tetraphenylethenes as Novel On–Off–On Cascade Sensors of Copper and Glutathione

Bayindir,

Akar

2024

ACS Omega

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This study reports the synthesis of novel fluorescent probes, phenol-hydrazide-appended tetraphenylethenes (TPEs I and II), and explores their photochemical properties. The probes exhibit aggregation-induced emission (AIE) in increasing water content, as observed using fluorescence spectroscopy. Further investigation with UV−vis and fluorescence techniques revealed their potential as ion sensors. Both TPE I and TPE II act as "turnoff" sensors for Cu 2+ ions, showing decreased fluorescence intensity in their presence. Their limit of detection (LOD) and association constant (K a ) for Cu 2+ were found to be comparable at 747 nM/597 nM, and 2.46 × 10 5 M −1/2 /1.78 × 10 5 M −1/2 , respectively. Moreover, the quantum yields of TPE I and TPE II were also calculated and found to be 0.651 and 0.325, respectively. Interestingly, these probes also function as "turn-on" sensors for glutathione (GSH) in the presence of copper. This means their fluorescence can be reversibly switched off and on by alternating CuCl 2 and GSH additions. Moreover, the LOD values for GSH with TPE II−Cu 2+ were calculated to be 544 nM. In addition, the investigation also employed visual analysis to assess the color alterations of TPEs on filter paper and in real water samples. Overall, this research introduces promising new probes with potential applications in copper ion detection and biomolecule glutathione sensing in real water samples.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthesis of Phenol-Hydrazide-Appended Tetraphenylethenes as Novel On–Off–On Cascade Sensors of Copper and Glutathione

Bayindir,

Akar

2024

ACS Omega

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“…According to these changes, the input analyte can be analyzed [25]. Surface plasmon resonance (SPR) [27,28], fluorescence [29,30], surface-enhanced Raman scattering (SERS) [31,32], and colorimetric detection are methods used for optical biosensors [33]. Surface plasmon occurs when photons in the incident wave encounter electrons on the surface of the metal and are analyzed due to the shift in the refractive index caused by this encounter [34].…”

Section: Introductionmentioning

confidence: 99%

Optical biosensors for diagnosis of COVID-19: nanomaterial-enabled particle strategies for post pandemic era

Tekin,

Kul,

Sagdic

et al. 2024

Microchim Acta

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The COVID-19 pandemic underlines the need for effective strategies for controlling virus spread and ensuring sensitive detection of SARS-CoV-2. This review presents the potential of nanomaterial-enabled optical biosensors for rapid and low-cost detection of SARS-CoV-2 biomarkers, demonstrating a comprehensive analysis including colorimetric, fluorescence, surface-enhanced Raman scattering, and surface plasmon resonance detection methods. Nanomaterials including metal-based nanomaterials, metal–organic frame–based nanoparticles, nanorods, nanoporous materials, nanoshell materials, and magnetic nanoparticles employed in the production of optical biosensors are presented in detail. This review also discusses the detection principles, fabrication methods, nanomaterial synthesis, and their applications for the detection of SARS-CoV-2 in four categories: antibody-based, antigen-based, nucleic acid–based, and aptamer-based biosensors. This critical review includes reports published in the literature between the years 2021 and 2024. In addition, the review offers critical insights into optical nanobiosensors for the diagnosis of COVID-19. The integration of artificial intelligence and machine learning technologies with optical nanomaterial-enabled biosensors is proposed to improve the efficiency of optical diagnostic systems for future pandemic scenarios. Graphical Abstract

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“…In this regard, homogeneous fluorescent methods open up new possibilities due to their simplicity, speed, and sensitivity [13][14][15][16]. For example, fluorescence polarization/ anisotropy-based immunoassays have been successfully used to detect AFB1 [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

A Fluorescence Resonance Energy Transfer Aptasensor for Aflatoxin B1 Based on Ligand-Induced ssDNA Displacement

Serebrennikova,

Samokhvalov,

Zherdev

et al. 2023

Molecules

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In this study, a fluorescence resonance energy transfer (FRET)-based aptasensor for the detection of aflatoxin B1 (AFB1) was designed using a carboxyfluorescein (FAM)-labeled aptamer and short complementary DNA (cDNA) labeled with low molecular quencher RTQ1. The sensing principle was based on the detection of restored FAM-aptamer fluorescence due to the ligand-induced displacement of cDNA in the presence of AFB1, leading to the destruction of the aptamer/cDNA duplex and preventing the convergence of FAM and RTQ1 at the effective FRET distance. Under optimal sensing conditions, a linear correlation was obtained between the fluorescence intensity of the FAM-aptamer and the AFB1 concentration in the range of 2.5–208.3 ng/mL with the detection limit of the assay equal to 0.2 ng/mL. The assay time was 30 min. The proposed FRET aptasensor has been successfully validated by analyzing white wine and corn flour samples, with recovery ranging from 76.7% to 91.9% and 84.0% to 86.5%, respectively. This work demonstrates the possibilities of labeled cDNA as an effective and easily accessible tool for sensitive AFB1 detection. The homogeneous FRET aptasensor is an appropriate choice for contaminant screening in complex matrices.

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Biomedical application of aggregation-induced emission luminogen-based fluorescent sensors

Cited by 9 publications

References 254 publications

Synthesis of Phenol-Hydrazide-Appended Tetraphenylethenes as Novel On–Off–On Cascade Sensors of Copper and Glutathione

Synthesis of Phenol-Hydrazide-Appended Tetraphenylethenes as Novel On–Off–On Cascade Sensors of Copper and Glutathione

Optical biosensors for diagnosis of COVID-19: nanomaterial-enabled particle strategies for post pandemic era

A Fluorescence Resonance Energy Transfer Aptasensor for Aflatoxin B1 Based on Ligand-Induced ssDNA Displacement

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