Biomechanisms for modelling cerebral cortical folding

Geng, Guangqiang; Johnston, Leigh A.; Yan, Edwin BingBing; Britto, Joanne M.; Smith, David W.; Walker, David; Egan, Gary F.

doi:10.1016/j.media.2008.12.005

Cited by 37 publications

(14 citation statements)

References 44 publications

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“…Borrell and colleagues have reported that in ferrets the density of dividing progenitors at P3 (3rd postnatal day, when the ferret cortex is still smooth) was higher under the region that will become later the splenial gyrus compared with the neighbouring regions, that will become sulci. Alternatively, folds could result from bending due to the active contraction of axonal fibres connecting different neocortical areas together (Van Essen, 1997;Geng et al, 2009;Barbas, 2005, 2006). Van Essen (1997) reported that neighbouring areas with strong interconnections were more often on facing sides of a gyrus, compared with weakly connected areas, which tended to be separated by a sulcus.…”

Section: Development Of Neocortical Arealisationmentioning

confidence: 99%

Mechanical morphogenesis and the development of neocortical organisation

Foubet

Toro

2015

Preprint

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The development and evolution of complex neocortical organisations is thought to result from the interaction of genetic and activity-dependent processes. Here we propose that a third type of process -mechanical morphogenesis -may also play an important role. We review recent theoretical and experimental results in non-linear physics showing how homogeneous growth can produce a rich variety of forms, in particular neocortical folding. The mechanical instabilities that produce these forms also induce heterogeneous patterns of stress at the scale of the organ. We review the evidence showing how these stresses can influence cell proliferation, migration and apoptosis, cell differentiation and shape, migration and axonal guidance, and could thus be able to influence regional neocortical identity and connectivity.

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Section: Development Of Neocortical Arealisationmentioning

confidence: 99%

Mechanical morphogenesis and the development of neocortical organisation

Foubet

Toro

2015

Preprint

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“…For small ratios of layer to foundation stiffness, µ l /µ s 10, the system instead localizes the deformation and a fold or crease develops. For many biological systems, it is the latter scenario that is of most interest; for example, the deep folding patterns that are formed during the growth of brains are believed to be partially caused by this instability [11,13,17].…”

Section: Introductionmentioning

confidence: 99%

Wrinkling, creasing, and folding in fiber-reinforced soft tissues

Stewart

Waters

Sayed

et al. 2016

Extreme Mechanics Letters

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Many biological tissues develop elaborate folds during growth and development. The onset of this folding is often understood in relation to the creasing and wrinkling of a thin elastic layer that grows whilst attached to a large elastic foundation. In reality, many biological tissues are reinforced by fibres and so are intrinsically anisotropic. However, the correlation between the fiber directions and the pattern formed during growth is not well understood. Here, we consider the stability of a two-layer tissue composed of a thin hyperelastic strip adhered to an elastic half-space in which are embedded elastic fibers. The combined object is subject to a uniform compression and, at a critical value of this compression, buckles out of the plane -it wrinkles. We characterize the wrinkle wavelength at onset as a function of the fiber orientation both computationally and analytically and show that the onset of surface instability can be either promoted or inhibited as the fiber stiffness increases, depending on the fibre angle. However, we find that the structure of the resulting folds is approximately independent of the fiber orientation. We also explore numerically the formation of large creases in fiber-reinforced tissue in the post-buckling regime.

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“…Tension-induced wrinkling of elastic thin films was studied by Cerda and Mahadevan [21], and strain incompatibility due to Poisson effect was found as the major wrinkling mechanism. Large mismatch in stiffness of constituents was also a key factor in creating wrinkles on composite surface layers such as soft biological tissues and soft-hard materials interfaces [22][23][24]. Inspired by the mismatch factor, Chen and Elbanna recently showed that a composite film with periodic arrangement of stiff strips transferprinted on a compliant substrate wrinkles under tension, and the tension and periodic arrangement control the amplitude of wrinkles (corrugation) [25].…”

Section: Introductionmentioning

confidence: 99%

Frictional Energy Dissipation in Wavy Surfaces

Liu

Eriten

2016

Journal of Applied Mechanics

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Accurate estimation and tuning of frictional damping are critical for proper design, safety, and reliability of assembled structures. In this study, we investigate how surface geometry and boundary conditions affect frictional energy dissipation under microslip contact situations. In particular, we investigate the frictional losses of a two-dimensional (2D) deformable wavy surface in contact with rigid plate under specific normal and tangential loading. We also propose a dissipation tuning mechanism by tension-induced wrinkling of a composite surface. This surface is made of stiff strips printed on a compliant substrate. We show that the contact geometry of wrinkling surfaces can be altered significantly by tensile loading and design of the composite surface. Using this, we present frictional dissipation maps as functions of applied tension and one of the geometric parameters in the composite design; spacing between stiff strips. Those maps illustrate the dissipation tuning capability of wrinkled surfaces, and thus present a unique mean of damping control.

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Biomechanisms for modelling cerebral cortical folding

Cited by 37 publications

References 44 publications

Mechanical morphogenesis and the development of neocortical organisation

Mechanical morphogenesis and the development of neocortical organisation

Wrinkling, creasing, and folding in fiber-reinforced soft tissues

Frictional Energy Dissipation in Wavy Surfaces

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