Biomechanics of the Human Urinary Bladder

Miftahof, Roustem N.; Nam, Hong Gil

doi:10.1007/978-3-642-36146-3

Cited by 10 publications

(13 citation statements)

References 121 publications

(118 reference statements)

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“…Urinary bladder compliance is a result of passive bladder wall elasticity mainly corresponding to ECM biomechanics and smooth muscle tension regulated by the nervous system (Miftahof & Nam, ). Current biotechnology struggles to provide tools for simultaneously enhancing the regeneration of all histological components and building a bladder wall.…”

Section: Tissue Engineering Strategies For Urinary Tract Reconstructionmentioning

confidence: 99%

Reconstructive urology and tissue engineering: Converging developmental paths

Adamowicz

Kuffel

Breda

et al. 2019

J Tissue Eng Regen Med

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Reconstructive urology is a complex and demanding branch of modern urology.Complicated cases, necessity of microsurgical approach, and constant exposure to urine make urinary reconstruction especially difficult. With impaired healing, excessive scarring, and recurring fibrosis, functional results are still not satisfying.For better, more successful outcomes, a novel tissue engineering technology-based solutions are being gradually investigated. The use of tissue engineering is the most promising strategy to improve results of reconstructive urology procedures due to possibility of designing organ-specific grafts. Moreover, targeted modification of healing environment by stem cells and growth factors is a unique opportunity that might bring reconstructive urology on molecular level. This review defined limitations and problems encountered in reconstructive urology and discussed relevant tissue engineering-based achievements in the field of urethra, urinary bladder, and ureter regeneration. The background justifying tissue engineering approach to urethra, urinary bladder, and ureter reconstruction was discussed. Then, the wide range of experimental methods utilising biomaterials and cell seeding was deliberated to show readers the current tools offered by tissue engineering. At the end, we characterised major challenges that are needed to be addressed before tissue entering would become standard technology in urological departments.

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Section: Tissue Engineering Strategies For Urinary Tract Reconstructionmentioning

confidence: 99%

Reconstructive urology and tissue engineering: Converging developmental paths

Adamowicz

Kuffel

Breda

et al. 2019

J Tissue Eng Regen Med

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“…conditions relevant to understanding material changes that take place under certain pathologies (15,36). However, in silico models have not yet provided a comprehensive description of normal and pathological bladder behavior (23), indicating that additional studies are required to biomechanically characterize detrusor smooth muscle (DSM).…”

mentioning

confidence: 99%

Slowly cycling Rho kinase-dependent actomyosin cross-bridge “slippage” explains intrinsic high compliance of detrusor smooth muscle

Neal

Lin

Hurley

et al. 2017

American Journal of Physiology-Renal Physiology

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Biological soft tissues are viscoelastic because they display time-independent pseudoelasticity and time-dependent viscosity. However, there is evidence that the bladder may also display plasticity, defined as an increase in strain that is unrecoverable unless work is done by the muscle. In the present study, an electronic lever was used to induce controlled changes in stress and strain to determine whether rabbit detrusor smooth muscle (rDSM) is best described as viscoelastic or viscoelastic plastic. Using sequential ramp loading and unloading cycles, stress-strain and stiffness-stress analyses revealed that rDSM displayed reversible viscoelasticity, and that the viscous component was responsible for establishing a high stiffness at low stresses that increased only modestly with increasing stress compared with the large increase produced when the viscosity was absent and only pseudoelasticity governed tissue behavior. The study also revealed that rDSM underwent softening correlating with plastic deformation and creep that was reversed slowly when tissues were incubated in a Ca-containing solution. Together, the data support a model of DSM as a viscoelastic-plastic material, with the plasticity resulting from motor protein activation. This model explains the mechanism of intrinsic bladder compliance as "slipping" cross bridges, predicts that wall tension is dependent not only on vesicle pressure and radius but also on actomyosin cross-bridge activity, and identifies a novel molecular target for compliance regulation, both physiologically and therapeutically.

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“…Th e bladder is a hollow muscular organ, and its wall consists of four layers, from the innermost to the outermost, mucous, submucous layer, muscular and serous layer. Details on the morphology can be found in many text books and dedicated reviews [16][17][18][19] . Th e innermost layer, the tunica muscosa, is made of a thin layer of stratifi ed transitional epithelial cells (e.g., basal cells, intermediate cells and umbrella cells).…”

Section: Invited Articlementioning

confidence: 99%

“…In the 1990s and early 2000s, the focus shifted from the description of the passive behavior only, to the characterization of the mechanics of the UBW both in its passive and active phase. Multiple authors 18,40,41 hypothesized that the total stress acting on the muscles in the detrusor could be defined as the sum of a passive stress and an active stress. Specifically, in Coldinq-Jørqensen and Steven 40 , the behavior of a SMC sheet has been modeled as a sum of parallel muscle strips.…”

Section: Passive and Active Behavior Of The Ubwmentioning

confidence: 99%

“…good results when compared to a set of planar biaxial mechanical tests performed on whole and decellularized tissue in the control and post spinal cord injured rats. More recently, Mift ahof and Nam developed a model for the active and passive behavior of the detrusor 18 . In this work, the authors modeled the behavior of the UBW, once again, as the summation of a passive and an active stress.…”

Section: Invited Articlementioning

confidence: 99%

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Understanding the mechanics of the bladder through experiments and theoretical models: Where we started and where we are heading

Roccabianca

Bush

2016

Technology

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Bladder control problems affect both men and women and range from an overactive bladder, to urinary incontinence, to bladder obstruction and cancer. These disorders affect more than 200 million people worldwide. Loss of bladder function significantly affects the quality of life, both physically and psychologically, and also has a large impact on the healthcare system, i.e., the incurring costs related to diagnosis, treatment and medical/nursing care. Improvements in diagnostic capabilities and disease management are essential to improve patient care and quality of life and reduce the economic burden associated with bladder disorders. This paper summarizes some of the key contributions to understanding the mechanics of the bladder ranging from work conducted in the 1970s through the present time with a focus on material testing and theoretical modeling. Advancements have been made in these areas and a significant contribution to these changes was related to technological improvements.

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Biomechanics of the Human Urinary Bladder

Cited by 10 publications

References 121 publications

Reconstructive urology and tissue engineering: Converging developmental paths

Reconstructive urology and tissue engineering: Converging developmental paths

Slowly cycling Rho kinase-dependent actomyosin cross-bridge “slippage” explains intrinsic high compliance of detrusor smooth muscle

Understanding the mechanics of the bladder through experiments and theoretical models: Where we started and where we are heading

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