Biomechanics of the Human Stomach

Miftahof, Roustem N.

doi:10.1007/978-3-319-59677-8_11

Cited by 2 publications

(3 citation statements)

References 27 publications

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“…In humans, the concave edge on the right side of the stomach is called a minor curve, and the convex edge on the left is called a significant curve (Figure 2). The part of the stomach that connects to the esophagus is called the cardia (Miftahof, 2017). The fundus, body (corpus), and antrum are the main sections of the stomach (Brandstaeter et al., 2019) (Figure 2).…”

Section: In Vitro Simulated Digestionmentioning

confidence: 99%

Guidelines for in vitro simulated digestion and absorption of food

et al. 2022

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With the continuous improvement of people's living standards, food intake, bioactivity, and bioavailability have mainly concerned people. Therefore, the digestion and absorption of this kind of food have attracted people's attention. Some food has very high nutritional, medicinal, and medical value. However, because of its low conversion rate and utilization rate, the human body digests and absorbs less material, so the use of human value will be significantly reduced. Therefore, simulation and testing of digestion and absorption in vitro may be significant for dietary intake of bioactive substances. This paper reviews the organs and pathways of simulated food digestion and absorption in vitro and specific processing methods. In an in the vitro simulation system, the role of the human digestive system and absorption system in food digestion and absorption is described, and the performance of various simulation models, exceptionally dynamic in vitro models, is compared. Widespread use and refinement of these models will expand our understanding of the complex interplay of food substrates and digestive and absorptive systems. Therefore, it will be possible to design food with better bioavailability, more benefits to human health, and more targeted delivery, which is also in line with the development trend of food in the future.

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Section: In Vitro Simulated Digestionmentioning

confidence: 99%

Guidelines for in vitro simulated digestion and absorption of food

et al. 2022

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“…More refined models of structural mechanics can be found in the literature (Miftahof 2017; Carniel et al 2017). …”

Section: Bolus-esophageal-gastric Modelmentioning

confidence: 99%

“…This greatly simplified stomach model was used because the region of interest in this work was confined to the LES region. More refined models of structural mechanics can be found in the literature (Miftahof 2017; Carniel et al 2017).…”

Section: Bolus-esophageal-gastric Modelmentioning

confidence: 99%

Studies of abnormalities of the lower esophageal sphincter during esophageal emptying based on a fully coupled bolus–esophageal–gastric model

Kou

Pandolfino

Kahrilas

et al. 2018

Biomech Model Mechanobiol

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The aim of this work was to develop a fully coupled bolus-esophageal-gastric model based on the immersed boundary-finite element method to study the process of esophageal emptying across the esophagogastric junction (EGJ). The model included an esophageal segment, an ellipsoid-shaped stomach, a bolus, and a simple model of the passive and active sphincteric functions of the lower esophageal sphincter (LES). We conducted three sets of case studies: (1) the effect of a non-relaxing LES; (2) the influence of the tissue anisotropy in the form of asymmetrical right- and left-sided compliance of the LES segment; and (3) the influence of LES and gastric wall stiffness on bulge formation of the distal esophageal wall. We found that a non-relaxing LES caused sustained high wall stress along the LES segment and obstruction of bolus emptying. From the simulations of tissue anisotropy, we found that the weaker side (i.e., more compliant) of the LES segment sustained greater deformation, greater wall shear stress, and a greater high-pressure load during bolus transit. In the third set of studies, we found that a right-sided bulge in the esophageal wall tends to develop during esophageal emptying when LES stiffness was decreased or gastric wall stiffness was increased. Hence, the bulge may be partly due to the asymmetric configuration of the gastric wall with respect to the esophageal tube. Together, the observations from these simulations provide insight into the genesis of epiphrenic diverticula, a complication observed with esophageal motility disorders. Future work, with additional layers of complexity to the model, will delve into the mechanics of gastroesophageal reflux and the effects of hiatus hernia on EGJ function.

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Biomechanics of the Human Stomach

Cited by 2 publications

References 27 publications

Guidelines for in vitro simulated digestion and absorption of food

Guidelines for in vitro simulated digestion and absorption of food

Studies of abnormalities of the lower esophageal sphincter during esophageal emptying based on a fully coupled bolus–esophageal–gastric model

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