Biomechanics of the Human Stomach

Miftahof, Roustem N.

doi:10.1007/978-3-319-59677-8

Cited by 7 publications

(4 citation statements)

References 27 publications

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“…The antrum is conical and lies between the lower part of the body and the pyloric canal. The pylorus is the thinnest part of the stomach, surrounded by a thick layer of smooth muscle (Miftahof et al, 2017;Rogers, 2011). The nervous system tightly controls the sphincter connecting the stomach, esophagus, and duodenum (Figure 2).…”

Section: In Vitro Simulated Digestionmentioning

confidence: 99%

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Guidelines for in vitro simulated digestion and absorption of food

et al. 2022

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With the continuous improvement of people's living standards, food intake, bioactivity, and bioavailability have mainly concerned people. Therefore, the digestion and absorption of this kind of food have attracted people's attention. Some food has very high nutritional, medicinal, and medical value. However, because of its low conversion rate and utilization rate, the human body digests and absorbs less material, so the use of human value will be significantly reduced. Therefore, simulation and testing of digestion and absorption in vitro may be significant for dietary intake of bioactive substances. This paper reviews the organs and pathways of simulated food digestion and absorption in vitro and specific processing methods. In an in the vitro simulation system, the role of the human digestive system and absorption system in food digestion and absorption is described, and the performance of various simulation models, exceptionally dynamic in vitro models, is compared. Widespread use and refinement of these models will expand our understanding of the complex interplay of food substrates and digestive and absorptive systems. Therefore, it will be possible to design food with better bioavailability, more benefits to human health, and more targeted delivery, which is also in line with the development trend of food in the future.

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Section: In Vitro Simulated Digestionmentioning

confidence: 99%

“…In humans, the concave edge on the right side of the stomach is called a minor curve, and the convex edge on the left is called a significant curve (Figure 2). The part of the stomach that connects to the esophagus is called the cardia (Miftahof, 2017).…”

Section: In Vitro Simulated Digestionmentioning

confidence: 99%

Guidelines for in vitro simulated digestion and absorption of food

et al. 2022

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“…We utilised the finite element method (FEM) in order to predict the behaviour of the post-operative stomach under specific biological conditions. FEM is a commonly used mathematical method to solve complex mechanical and biological problems using sophisticated computing [11,12]. A larger structure is reduced into individual finite elements and their behaviour under specific conditions is solved during repeated simulation.…”

Section: Key Pointsmentioning

confidence: 99%

Mechanism of Staple Line Leak After Sleeve Gastrectomy via Isobaric Pressurisation Concentrating Stress Forces at the Proximal Staple Line

et al. 2022

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Purpose Staple line leak following sleeve gastrectomy is a significant problem and has been hypothesised to be related to hyperpressurisation in the proximal stomach. There is, however, little objective evidence demonstrating how these forces could be transmitted to the luminal wall. We aimed to define conditions in the proximal stomach and simulate the transmission of stress forces in the post-operative stomach using a finite element analysis (FEA). Materials and Methods The manometry of fourteen patients post sleeve gastrectomy was compared to ten controls. Manometry, boundary conditions, and volumetric CT were integrated to develop six models. These models delineated luminal wall stress in the proximal stomach. Key features were then varied to establish the influence of each factor. Results The sleeve gastrectomy cohort had a significantly higher peak intragastric isobaric pressures 31.58 ± 2.1 vs. 13.49 ± 1.3 mmHg (p = 0.0002). Regions of stress were clustered at the staple line near the GOJ, and peak stress was observed there in 67% of models. A uniform greater curvature did not fail or concentrate stress under maximal pressurisation. Geometric variation demonstrated that a larger triangulated apex increased stress by 17% (255 kPa versus 218 kPa), with a 37% increase at the GOJ (203kPA versus 148kPA). A wider incisura reduced stress at the GOJ by 9.9% (128 kPa versus 142 kPa). Conclusion High pressure events can occur in the proximal stomach after sleeve gastrectomy. Simulations suggest that these events preferentially concentrate stress forces near the GOJ. This study simulates how high-pressure events could translate stress to the luminal wall and precipitate leak. Graphical Abstract

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“…The stomach is known to exhibit nonlinear, anisotropic and viscoelastic properties (Gregersen, 2003;Miftahof, 2017). The anisotropic and nonlinear elastic behavior has been examined by quasi-static tests on animal or human gastric tissue (Aydin et al, 2017;Bauer et al, 2020;Carniel et al, 2020;Egorov et al, 2002;Jia et al, 2015;Rotta et al, 2019;Toniolo et al, 2022;Yamada, 1970;Zhao et al, 2008Zhao et al, , 2005.…”

Section: Introductionmentioning

confidence: 99%