Biomechanics of Scar Tissue and Uninjured Skin

Mitigation of hypertrophic scar contraction via an elastomeric biodegradable scaffold

“…We postulate that the mechanical properties of human skin are critical to consider during the design of a scaffold for HSc prevention. Scaffolds with tensile elastic moduli greater than human skin may inhibit joint motion, similar to how stiffened scar inhibits motion [24,35]. Therefore, BSEs should possess an elastic modulus less than or equal to that of human skin.…”

“…break and ultimate tensile stress less than that of human skin may cause a scaffold to rupture beneath the skin prior to completion of healing. Along with its tensile characteristics, skin is viscoelastic in nature, allowing it to stretch and relax across joints repetitively [35]. Burns that occur across joints, especially those of the upper body, are the most common location for HSc to occur [1].…”

Finite Element Model Analysis of Cephalic Trim on Nasal Tip Stability

“…10,15–17 There is sparse information with respect to (1) time-dependent evolution of force across a healing surgical incision, (2) the magnitude of these forces as a function of time, and (3) the way these changes alter tissue mechanical properties locally and at a distance over time. Hence, experimental data are inadequate to simulate true wound healing.…”

The pathophysiologic basis of abdominal aortic aneurysm progression: a critical appraisal

“…impaired matrix homeostasis ('disturbed repair') in AAA disease. The histological, biochemical and molecular signature of the matrix in large AAA is that of fibrosis [111], with clear qualitative defects in the newly formed extracellular matrix (FIGURES 1 & 4) that include defects in wall (micro) architecture [15], factors that may contribute to weakening of the aneurysm wall [112]. On the cellular level, the disease is characterized by both quantitative and qualitative changes in the mesenchymal cell population.…”