Biomechanics of osteochondral impact with cushioning and graft Insertion: Cartilage damage is correlated with delivered energy

Su, Alvin W.; Chen, Yunchan; Yang, Dong; Wailes, Dustin H; Wong, Van W.; Chen, Albert C.; Cai, Shengqiang; Bugbee, William D.; Sah, Robert L.

doi:10.1016/j.jbiomech.2018.03.037

Cited by 11 publications

(9 citation statements)

References 35 publications

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“…It could be found that the impact modulus and impact energy of bicontinuous hydrogel are superior to the NBR rubber and cartilage. 47,48…”

Section: Resultsmentioning

confidence: 99%

“…It could be found that the impact modulus and impact energy of bicontinuous hydrogel are superior to the NBR rubber and cartilage. 47,48 Fig. 5 Schematic illustrations of the mechanism of hierarchical energy dissipation in the bicontinuous hydrogel.…”

Section: Dynamic Impact Resistant Propertymentioning

confidence: 99%

“…(d) The impact energy calculated by integrating the area of the stress-strain curve. (e) Comparison of dynamic impact property in impact energy in relation with Quasi-Satic Young's modulus for the bicontinuous and homogeneous hydrogels, reported tough hydrogels, NBR rubber, cartilage 47,48.…”

mentioning

confidence: 99%

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An impact resistant hydrogel enabled by bicontinuous phase structure and hierarchical energy dissipation

Qiu

Liu

et al. 2023

J. Mater. Chem. B

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“…It could be found that the impact modulus and impact energy of bicontinuous hydrogel are superior to the NBR rubber and cartilage. 47,48…”

Section: Resultsmentioning

confidence: 99%

Section: Dynamic Impact Resistant Propertymentioning

confidence: 99%

See 1 more Smart Citation

An impact resistant hydrogel enabled by bicontinuous phase structure and hierarchical energy dissipation

Qiu

Liu

et al. 2023

J. Mater. Chem. B

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“…There are several limitations to the present study. First, in addition to the magnitude of load, injuries would also be affected by loading rate 31–33 , which cannot be separated in the present drop‐tower impacting configuration. Therefore, the rabbit model cannot completely simulate motor vehicle dashboard‐type injury.…”

Section: Discussionmentioning

confidence: 99%

A Post‐Traumatic Osteoarthritic Model of Hip Following Fracture of Acetabulum in Rabbit: A Preliminary Study by Macroscopic and Radiographic Assessment

Feng

Liu

et al. 2021

Orthopaedic Surgery

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Objective To develop a post‐traumatic osteoarthritic model of hip following fracture of acetabulum in rabbit for revealing biochemical mechanism of post‐traumatic osteoarthritis. Methods A total of 36 mature male New Zealand white rabbits were equally divided into sham group (n = 12), non‐ORIF group (n = 12), and open reduction and internal fixation (ORIF) group (n = 12). Except for the sham group, rabbits had survival surgeries to create acetabular fractures of dorsal wall for simulating dashboard impaction mechanism. The ORIF group received open reduction and internal fixation, while fractures in the non‐ORIF group were left as displaced but transverse fracture and dislocation was reduced. Besides intraoperative appearance and postoperative recovery, macroscopic and radiographic characteristics of the hips were recorded and assessed by a radiographic scoring scale at 3 weeks, 6 weeks, and 6 months, respectively. Results Out of 24 modeled acetabula, 21 (87.5%) were pure dorsal wall fractures as proposed and the remaining three were associated fractures (dorsal wall plus transverse fracture) accompanied by dorsal dislocation or not. All hips were stable, and no sciatic nerve injury was observed. One rabbit in the ORIF group died of deep infection 4 days after surgery. Rabbits in the sham and ORIF groups returned to normal gait in 2 weeks, but animals in the non‐ORIF group suffered from limping and restricted movement. As the time progressed, the hips in the non‐ORIF group experienced progressive and severe degeneration which exhibited dramatically malformed and hypertrophic joints at 6 months, but the ORIF group maintained much better morphological structure. Corresponding to morphological changes, the average radiographic scores of the non‐ORIF group increased from 1.25 at 3 weeks to 2.75 at 6 months and showed statistically significant difference when compared to the sham group at all three time points (P = 0.011, 0.011, 0.015, respectively, <0.0167). Although the scores of the ORIF group showed apparent improvements (increased from 0.67 at 3 weeks to 2.00 at 6 months), there was no significant difference between the two modeled groups at all three time points. Conclusion The fracture model with high consistency and reproducibility showed progressive post‐traumatic osteoarthritic changes which could be improved by open reduction and internal fixation surgery and provided an alternative selection for investigating potential pathogenesis and pathology of post‐traumatic osteoarthritis following fracture of acetabulum.

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“…Longer grafts were found to require an increased number of insertional impacts and cumulative impact force detrimental to surface chondrocyte viability and graft survival. [12][13][14] Studies exist evaluating the biomechanical properties of OCAs of 7 mm in depth and longer, but no study has clearly defined the minimal graft depth required to resist deforming forces. [15][16][17] Deforming forces leading to graft protrusion or subsidence of more than 1 mm can lead to unfavorable outcomes and fibrocartilaginous, rather than osteochondral incorporation.…”

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confidence: 99%

Osteochondral Allograft Transplantation: Identifying the Biomechanical Impact of Using Shorter Grafts and Pulsatile Lavage on Graft Stability

et al. 2018

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This study seeks to identify the ability of shorter osteochondral allografts (OCAs) to resist displacement/failure. Additionally, this study seeks to evaluate the effect of pulsatile lavage (PL) on the biomechanical stability of the OCA. Fifteen-millimeter diameter, human cadaveric, OCAs of 4, 7, and 10 mm in depth were harvested for comparison of resistance to compressive and tensile loads. For each group, seven specimens were subjected to tensile loads and three specimens subjected to compressive loads until failure (pullout or subsidence). An additional study group of 10 pulsatile-lavaged OCAs of 15 mm in diameter and 7 mm in depth were introduced for comparison to the original 7 mm depth OCA group. The average tensile forces for failure for the 4, 7, and 10 mm plugs were 23.74, 199.57, and 197.69 N, respectively (p = 1.5 × 10−5). After post hoc analysis of the tensile groups, significant differences in the mean tensile force to failure were appreciated between the 4 and 7 mm groups (p = 4.12 × 10−5) and the 4 and 10 mm groups (p = 1.78 × 10−5) but not between the 7 and 10 mm groups (p = 0.9601). There were no significant differences between the average tensile forces resulting in failure for the 7 mm and 7 mm PL groups (199.57 and 205.2 N, p = 0.90) or compressive forces to failure, respectively (733.6 and 656 N, p = 0.7062). For OCAs of 15 mm in diameter, a commonly used size in practice, plugs of 7 mm in depth showed comparable resistance to pull out and subsidence as 10 mm plugs and significantly better resistance to pull out than 4 mm grafts. PL of allografts prior to insertion did not take away from the structural integrity and stability of the plug.

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Biomechanics of osteochondral impact with cushioning and graft Insertion: Cartilage damage is correlated with delivered energy

Cited by 11 publications

References 35 publications

An impact resistant hydrogel enabled by bicontinuous phase structure and hierarchical energy dissipation

An impact resistant hydrogel enabled by bicontinuous phase structure and hierarchical energy dissipation

A Post‐Traumatic Osteoarthritic Model of Hip Following Fracture of Acetabulum in Rabbit: A Preliminary Study by Macroscopic and Radiographic Assessment

Osteochondral Allograft Transplantation: Identifying the Biomechanical Impact of Using Shorter Grafts and Pulsatile Lavage on Graft Stability

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