Bone
and tooth defects can considerably affect the quality of life
and health of patients, and orthopedic implants remain the primary
method of addressing such defects. However, implant materials cannot
coordinate with the immune microenvironment because of their biological
inertness, which may lead to implant loosening or failure. Motivated
by the microstructure of nacre, we engineered a biomimetic micro/nanoscale
topography on a tantalum surface using a straightforward method. This
comprised an organized array of tantalum nanotubes arranged in a brick
wall structure, with epigallocatechin gallate acting as “mortar.”
The coating improved the corrosion resistance, biocompatibility, and
antioxidant properties. In vitro and in vivo evaluations further confirmed
that coatings can create a favorable bone immune microenvironment
through the synergistic effects of mechanochemistry and enhance bone
integration. This research offers a new viewpoint on the creation
of sophisticated functional implants, possessing vast potential for
use in the regeneration and repair of bone tissue.