Biomechanics of Acute Subdural Hematoma in the Elderly: A Fluid-Structure Interaction Study

Zhou, Zhou; Li, Xiaogai; Kleiven, Svein

doi:10.1089/neu.2018.6143

Cited by 46 publications

(29 citation statements)

References 42 publications

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“…In recent decades, FE head models have been increasingly used to fill the knowledge gap between external loading, localized brain response, and resultant injury. [24][25][26][27][28][29] Partially inspired by the aforementioned mechanism that axonal elongation triggers TAI occurrence, various endeavors have been made recently to simulate deformation along WM fiber tracts (i.e., the tract-oriented strain). [30][31][32][33][34][35][36][37][38][39][40][41][42][43][44] Of note, the tract-oriented strain is synonymous with axonal strain or fiber strain, which are both terms used in multiple studies.…”

Section: Introductionmentioning

confidence: 99%

White matter tract-oriented deformation is dependent on real-time axonal fiber orientation

Zhou

Domel

et al. 2020

Preprint

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Traumatic axonal injury (TAI) is a critical public health issue with its pathogenesis remaining largely elusive. Finite element (FE) head models are promising tools to bridge the gap between mechanical insult and localized brain response and resultant injury. In particular, the FE-derived deformation along the direction of white matter (WM) tracts (i.e., tract-oriented strain) has been shown to be an appropriate predictor for TAI. However, the evolution of fiber orientation in time during the impact and its potential influence on tract-oriented strain remained unknown. To address this question, the present study leveraged an embedded element approach to track real-time fiber orientation during impacts. A new scheme to calculate the tract-oriented strain was proposed by projecting the strain tensors from pre-computed simulations along the temporal fiber direction instead of its static counterpart directly obtained from diffuse tensor imaging. The results revealed that incorporating the real-time fiber orientation not only altered the direction but also amplified the magnitude of the tract-oriented strain, resulting in a generally more extended distribution and a larger volume ratio of WM exposed to high deformation along fiber tracts. Results of this study provide important insights into how best to incorporate fiber orientation in head injury models and derive the WM tract-oriented deformation from computational simulations, which is important for furthering our understanding of the underlying mechanisms of TAI.

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Section: Introductionmentioning

confidence: 99%

White matter tract-oriented deformation is dependent on real-time axonal fiber orientation

Zhou

Domel

et al. 2020

Preprint

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“…In preference to the Lagrangian-based CSF representation, recent models have employed an arbitrary Lagrangian-Eulerian (ALE) multi-material formulation to describe the subarachnoid CSF combined with a fluid-structure coupling algorithm for the brain-skull interface. [36][37][38][39] However, such a modeling strategy has not been implemented for the brain-ventricle interface to date, especially in traumatic scenarios. This may be partially attributed to a highresolution description of the interfacial geometry being indispensable for fluid-structure interaction (FSI) implementation.…”

Section: Introductionmentioning

confidence: 99%

Biomechanics of Periventricular Injury

Zhou

Kleiven

2020

Journal of Neurotrauma

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Periventricular injury is frequently noted as one aspect of severe traumatic brain injury (TBI) and the presence of the ventricles has been hypothesized to be a primary pathogenesis associated with the prevalence of periventricular injury in patients with TBI. Although substantial endeavors have been made to elucidate the potential mechanism, a thorough explanation for this hypothesis appears lacking. In this study, a three-dimensional (3D) finite element (FE) model of the human head with an accurate representation of the cerebral ventricles is developed accounting for the fluid properties of the intraventricular cerebrospinal fluid (CSF) as well as its interaction with the brain. An additional model is developed by replacing the intraventricular CSF with a substitute with brain material. Both models are subjected to rotational accelerations with magnitudes suspected to induce severe diffuse axonal injury. The results reveal that the presence of the ventricles leads to increased strain in the periventricular region, providing a plausible explanation for the vulnerability of the periventricular region. In addition, the strain-exacerbation effect associated with the presence of the ventricles is also noted in the paraventricular region, although less pronounced than that in the periventricular region. The current study advances the understanding of the periventricular injury mechanism as well as the detrimental effects that the ventricles exert on the periventricular and paraventricular brain tissue.

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“…The fluid-like CSF utilizes an elastic solid material with fluid-like constitutive behavior and an equation of state constitutive model [13]. In recent years, many groups have shifted to the use of fluid-structure interaction (FSI) models [14][15][16][17][18]. Since the start of this project, recent work has shown that others are also attempting to use similar numerical methods to simulate FSI of CSF with brain, but with geometrically simplified 2D models [19].…”

Section: Introductionmentioning

confidence: 99%

“…While the importance of including CSF in the numerical simulations is now well-documented [21], the current finite element studies reported in the literature often lack more detailed anatomical structures [12,14,15,[22][23][24][25]. The brain is more complex in structure than what has been described in prior models.…”

Section: Introductionmentioning

confidence: 99%

Mechanism of Coup and Contrecoup Injuries Induced by a Knock-Out Punch

Toma

Chan-Akeley

Lipari

et al. 2020

MCA

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Primary Objective: The interaction of cerebrospinal fluid with the brain parenchyma in an impact scenario is studied. Research Design: A computational fluid-structure interaction model is used to simulate the interaction of cerebrospinal fluid with a comprehensive brain model. Methods and Procedures: The method of smoothed particle hydrodynamics is used to simulate the fluid flow, induced by the impact, simultaneously with finite element analysis to solve the large deformations in the brain model. Main Outcomes and Results: Mechanism of injury resulting in concussion is demonstrated. The locations with the highest stress values on the brain parenchyma are shown. Conclusions: Our simulations found that the damage to the brain resulting from the contrecoup injury is more severe than that resulting from the coup injury. Additionally, we show that the contrecoup injury does not always appear on the side opposite from where impact occurs.

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Biomechanics of Acute Subdural Hematoma in the Elderly: A Fluid-Structure Interaction Study

Cited by 46 publications

References 42 publications

White matter tract-oriented deformation is dependent on real-time axonal fiber orientation

White matter tract-oriented deformation is dependent on real-time axonal fiber orientation

Biomechanics of Periventricular Injury

Mechanism of Coup and Contrecoup Injuries Induced by a Knock-Out Punch

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