Biomechanical wall properties of human intracranial aneurysms resected following surgical clipping (IRRAs Project)

Costalat, Vincent; Sanchez, Mathieu; Ambard, Dominique; Thines, L.; Lonjon, Nicolas; Nicoud, Franck; Brunel, H.; Lejeune, Jean‐Paul; Dufour, H.; Bouillot, Pierre; J.P., Lhaldky,; K., Kouri,; Segnarbieux, F.; Maurage, Claude‐Alain; Lobotesis, Kyriakos; Villa‐Uriol, Maria‐Cruz; Zhang, Chong; Frangi, Alejandro F.; Mercier, Grégoire; Bonafé, Alain; Sarry, Laurent; Jourdan, F

doi:10.1016/j.jbiomech.2011.07.026

Cited by 77 publications

(88 citation statements)

References 29 publications

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“…Our results clearly suggest that the wall displacement provides information about the level of degradation of the aneurysm wall and, thanks to the findings of Costalat et al, 13 about the rupture risk of the aneurysm sac. Our study shows that whatever the location of the aneurysm on the circle of Willis, the aneurysmal pulsatility was about 7 times higher for soft/ruptured aneurysms in comparison with stiff/unruptured aneurysms (26% versus 4%).…”

Section: Discussionsupporting

confidence: 84%

“…The details of the study establishing the correlation between the aneurysm status and tissue mechanical properties are given in the work of Costalat et al 13 The methodology and main results are briefly given for the sake of completeness. A similar study was conducted by Duprey et al 15 for thoracic aortic aneurysms.…”

Section: Identification Of Mechanical Behavior Of Aneurysm Wallmentioning

confidence: 99%

“…5 The problem is the lack of data on mechanical properties of cerebral arteries and aneurysms; most of the studies based on an FSI 6-10 framework do not use experimental mechanical behavior of the aneurysm wall as input. A few exceptions exist for abdominal aorta aneurysms 11,12 but not for intracranial aneurysms until recently when, in a study by Costalat et al, 13 the aneurysm wall properties were characterized and a classification of aneurysm wall behavior was carried out. One of the main conclusions of this work was that the clinical status of the aneurysm (unruptured, preruptured, and ruptured) was strongly correlated with the mechanical behavior of the aneurysm wall and, hence, a classification was proposed (stiff, intermediate, and soft).…”

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confidence: 99%

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Intracranial Aneurysmal Pulsatility as a New Individual Criterion for Rupture Risk Evaluation: Biomechanical and Numeric Approach (IRRAs Project)

Sanchez

Ecker²,

Ambard

et al. 2014

American Journal of Neuroradiology

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BACKGROUND AND PURPOSE:The present study follows an experimental work based on the characterization of the biomechanical behavior of the aneurysmal wall and a numerical study where a significant difference in term of volume variation between ruptured and unruptured aneurysm was observed in a specific case. Our study was designed to highlight by means of numeric simulations the correlation between aneurysm sac pulsatility and the risk of rupture through the mechanical properties of the wall.

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Section: Discussionsupporting

confidence: 84%

Section: Identification Of Mechanical Behavior Of Aneurysm Wallmentioning

confidence: 99%

mentioning

confidence: 99%

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Intracranial Aneurysmal Pulsatility as a New Individual Criterion for Rupture Risk Evaluation: Biomechanical and Numeric Approach (IRRAs Project)

Sanchez

Ecker²,

Ambard

et al. 2014

American Journal of Neuroradiology

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“…This pattern of hemodynamic changes in the parent vessel visible with the large aneurysms leads us to make two hypotheses: (1) the parent vessel segment in-between the upstream and downstream measurement locations, including the diseased aneurysmal segment, presents an increased compliance (or distensibility) and/or (2) the aneurysm geometry induces significant flow modifications that affect the measurement in the downstream segment of the parent vessel. The first hypothesis is in good agreement with some biomechanical properties of aneurysm wall reported by some authors, [21][22][23] and especially a higher distensibility at the aneurysm's dome. 22 Indeed, we can reasonably assume that in large aneurysms the dome surface should be large and therefore induce significant impact on flow.…”

Section: Discussionsupporting

confidence: 90%

MR Derived Volumetric Flow Rate Waveforms of Internal Carotid Artery in Patients Treated for Unruptured Intracranial Aneurysms by Flow Diversion Technique

Boudjeltia

Corredor-Jerez

Bars

et al. 2015

J Cereb Blood Flow Metab

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Little is known about the hemodynamic disturbances induced by the cerebral aneurysms in the parent artery and the effect of flow diverter stents (FDS) on these latter. A better understanding of the aneurysm-parent vessel complex relationship may aid our understanding of this disease and to optimize its treatment. The ability of volumetric flow rate (VFR) waveform to reflect the arterial compliance modifications is well known. By analyzing the VFR waveform and the pulsatility in the parent vessel, this study aimed to test the hypotheses that (1) intracranial aneurysms might disrupt the blood flow of the parent vessel and (2) the treatment by FDS might have measurable corrective effect on these changes. Ten patients followed for unruptured intracranial aneurysms treated by FDS and ten healthy volunteers as control group were included in this study. Two-dimensional quantitative phase-contrast magnetic resonance imaging (MRI) was performed on each patient on the ICA artery upstream and downstream to the aneurysm, and on each volunteer at similar locations. The aneurysms altered significantly the parent vessel pulsatility and this effect was correlated to their volume. The aneurysms treatment by FDS allowed for the restoration of a normally modulated flow and pulsatility correction in the parent vessel.

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“…In computational simulations, vessel stress is calculated as a function of the vessel diameter [7,34], wall thickness [36,37], asymmetry [14,18,34,36], tortuosity [21], material property [17,24,29,38], calcification [15,22], intraluminal thrombus (ILT) [5,15,16,33], and blood flow [4, 9, 13, 14, 17, 20, 25, 26, 28-30, 32, 35-41]. Blood vessel strength is measured by ex vivo studies [11,12,23,31,44] or estimated by effective features such as ILT existence, sex, and genetic vulnerability [10]. Medical treatment techniques of aneurysms, mainly stent applications, are also investigated [35,40].…”

mentioning

confidence: 99%

Investigation of material modeling in fluid–structure interaction analysis of an idealized three-layered abdominal aorta: aneurysm initiation and fully developed aneurysms

Şimşek

Kwon

2015

J Biol Phys

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Different material models for an idealized three-layered abdominal aorta are compared using computational techniques to study aneurysm initiation and fully developed aneurysms. The computational model includes fluid-structure interaction (FSI) between the blood vessel and the blood. In order to model aneurysm initiation, the medial region was degenerated to mimic the medial loss occurring in the inception of an aneurysm. Various cases are considered in order to understand their effects on the initiation of an abdominal aortic aneurysm. The layers of the blood vessel were modeled using either linear elastic materials or Mooney-Rivlin (otherwise known as hyperelastic) type materials. The degenerated medial region was also modeled in either linear elastic or hyperelastic-type materials and assumed to be in the shape of an arc with a thin width or a circular ring with different widths. The blood viscosity effect was also considered in the initiation mechanism. In addition, dynamic analysis of the blood vessel was performed without interaction with the blood flow by applying time-dependent pressure inside the lumen in a three-layered abdominal aorta. The stresses, strains, and displacements were compared for a healthy aorta, an initiated aneurysm and a fully developed aneurysm. The study shows that the material modeling of the vessel has a sizable effect on aneurysm initiation and fully developed aneurysms. Different material modeling of degeneration regions also affects the stressstrain response of aneurysm initiation. Additionally, the structural analysis without considering FSI (called noFSI) overestimates the peak von Mises stress by 52% at the interfaces of the layers.

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Biomechanical wall properties of human intracranial aneurysms resected following surgical clipping (IRRAs Project)

Cited by 77 publications

References 29 publications

Intracranial Aneurysmal Pulsatility as a New Individual Criterion for Rupture Risk Evaluation: Biomechanical and Numeric Approach (IRRAs Project)

Intracranial Aneurysmal Pulsatility as a New Individual Criterion for Rupture Risk Evaluation: Biomechanical and Numeric Approach (IRRAs Project)

MR Derived Volumetric Flow Rate Waveforms of Internal Carotid Artery in Patients Treated for Unruptured Intracranial Aneurysms by Flow Diversion Technique

Investigation of material modeling in fluid–structure interaction analysis of an idealized three-layered abdominal aorta: aneurysm initiation and fully developed aneurysms

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