Biomechanical testing and degradation analysis of MgCa0.8 alloy screws: A comparative in vivo study in rabbits

Erdmann, Nina; Angrisani, Nina; Reifenrath, Janin; Lucas, Arne; Thorey, Fritz; Bormann, Dirk; Meyer‐Lindenberg, Andrea

doi:10.1016/j.actbio.2010.10.031

Cited by 199 publications

(112 citation statements)

References 34 publications

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“…In this regard, various methods such as selection on alloying elements [97][98][99][100], microstructural adjustment [101][102][103][104] and surface modification [96,105] have been applied. All the mentioned methods have been widely investigated for examining the in vivo and in vitro characteristics of common implant devices such as screws, plates, and pins [106][107][108]. In addition to the clinical trials of McBride and Verbrugge [109], at the first half of the 20th century, to employ Mg screws, plates and nails, recently, a few researchers [110,111] developed Mg-based implant devices and utilized them in patients'0 body to fix the bone fractures.…”

Section: Recent Developments Of Bm Wires In Bone Applicationsmentioning

confidence: 99%

Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Asgari

Hang

Chang

et al. 2018

Metals

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Abstract:Owing to significant advantages of bioactivity and biodegradability, biodegradable metallic materials such as magnesium, iron, and zinc and their alloys have been widely studied over recent years. Metallic wires with superior tensile strength and proper ductility can be fabricated by a traditional metalworking process (drawing). Drawn biodegradable metallic wires are popular biodegradable materials, which are promising in different clinical applications such as orthopedic fixation, surgical staples, cardiovascular stents, and aneurysm occlusion. This paper presents recent advances associated with the application of biodegradable metallic wires used in dental and orthopedic fields. Furthermore, the effects of some parameters such as the surface modification, alloying elements, and fabrication process affecting the degradation rate as well as biocompatibility, bioactivity, and mechanical stability are reviewed in the most recent works pertaining to these materials. Finally, possible pathways for future studies regarding the production of more efficient biodegradable metallic wires in the regeneration of bone defects are also proposed.

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Section: Recent Developments Of Bm Wires In Bone Applicationsmentioning

confidence: 99%

Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Asgari

Hang

Chang

et al. 2018

Metals

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“…Both alloys were chosen because of their promising biomechanical properties, and both had been evaluated in vivo in previous studies. [13][14][15][16][17][18][19][20][21] ZEK100 pins have shown promising initial mechanical stability. 15,20 Lensing et al reported good biocompatibility and an osteoconductive effect of ZEK100 in the middle ear of rabbit.…”

Section: Introductionmentioning

confidence: 99%

“…1,25 Several studies have investigated the properties and corrosion behavior of binary magnesium-calcium alloys. 13,14,18,19,[26][27][28][29][30] The addition of calcium provides solid solution strengthening and contributes to grain refinement owing to grain boundary strengthening. 1 It was observed that the addition of calcium above the solubility limit of approximately 1.34 wt% Ca enhanced the corrosion rate.…”

Section: Introductionmentioning

confidence: 99%

“…The accumulation of gas associated with MgCa0.8 implants was mild to moderate in vivo, with no harmful effects toward the animal. 14 In this in vitro study, we investigated the corrosion behavior and mechanical properties of two different alloys (MgCa0.8 and ZEK100) in Hank's Balanced Salt Solution (HBSS). The results were compared with a titanium alloy plate (Ti6Al4V) of similar sample size and shape.…”

Section: Introductionmentioning

confidence: 99%

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Comparative in vitro study and biomechanical testing of two different magnesium alloys

et al. 2013

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In this in vitro study, magnesium plates of ZEK100 and MgCa0.8 alloy similar to common titanium alloy osteosynthesis plates were investigated as degradable biomedical materials with a focus on primary stability. Immersion tests were performed in Hank's Balanced Salt Solution at 37 C. The bending strength of the samples was determined using the fourpoint bending test according to ISO 9585:1990. The initial strength of the noncorroded ZEK100 plate was 11% greater than that of the MgCa0.8 plate; both were approximately 65% weaker than a titanium plate. The bending strength was determined after 48 and 96 h of immersion in Hank's Balanced Salt Solution; both magnesium alloys decreased by approximately 7% after immersion for 96 h. The degradation rate and the Mg 2þ release of ZEK100 were lower than those of MgCa0.8. Strong pitting and filiform corrosion were observed in the MgCa0.8 samples after 96 h of immersion. The surface of the ZEK100 plates exhibited only small areas of filiform corrosion. The results of this in vitro study indicate that the ZEK100 alloy may be more suitable for biomedical applications.

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“…The latest developments include magnesium biodegradable stents which were successfully clinically tested on humans in the first decade of 21 th century [9]. In addition, magnesium based screws were recently shown to have excellent biocompatibility and bone-implant interface strength [16]. Despite these results, commercial medical implants containing Mg alloys are still not available.…”

Section: Introductionmentioning

confidence: 99%

Structure, Mechanical and Corrosion Properties of Magnesium Alloys for Medical Applications

Vojtěch¹,

Kubásek²

2013

Acta Metall. Slovaca Conf.

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Magnesium is considered as promising metal for construction of temporary biodegradable medical implants like stents or fixation devices for fractured bones. A biodegradable implant progressively corrodes in human body fluids and is replaced by the healing tissue. This paper presents structural, mechanical and corrosion properties of as-cast Mg, Mg-3X (in wt. %, X = Zn, Sn, Gd, Nd), AZ31 (Mg-3Al-1Zn), AJ62 (Mg-6Al-2Sr) and WE43 (Mg-4Y-3RE-0.5Zr, RE = rare earths) alloys. All the alloys were composed of α-Mg solid solution and interdendritic intermetallic phases. Hardness and tensile strength increased with incresing the total amount of alloying elements. Moreover, rare earths elements showed strong strengthening effects. The best corrosion resistance in the simulated physiological solution was observed in the case of alloys containing rare earts elements.

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Biomechanical testing and degradation analysis of MgCa0.8 alloy screws: A comparative in vivo study in rabbits

Cited by 199 publications

References 34 publications

Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Comparative in vitro study and biomechanical testing of two different magnesium alloys

Structure, Mechanical and Corrosion Properties of Magnesium Alloys for Medical Applications

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