Biomechanical properties of the mandibular condylar cartilage and their relevance to the TMJ disc

Singh, Milind; Detamore, Michael S.

doi:10.1016/j.jbiomech.2008.12.012

Cited by 88 publications

(84 citation statements)

References 97 publications

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“…Plowing has been extensively investigated in the temporomandibular joint (TMJ), in particular in its fibrocartilaginous disc, which is subject to compression by the underlying mandibular condyle that in general translates and rotates simultaneously (Donzelli et al, 2004;Mow et al, 1993;Nickel et al, 2009;Adams et al, 2009;Detamore and Athanasiou, 2003;Singh and Detamore, 2009;Tanaka, 2003). In our previous work, the complex TMJ disc deformation, and thus indirectly its loading, has been studied quantitatively from in vivo data by coupling magnetic resonance imaging (MRI) and jaw-tracking of human subjects (Gallo et al, 2000;Gallo, 2005;Gallo et al, 2006;Palla et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Coupling plowing of cartilage explants with gene expression in models for synovial joints

Correro-Shahgaldian

Colombo

Spencer

et al. 2011

Journal of Biomechanics

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Articular cartilage undergoes complex loading modalities generally including sliding, rolling and plowing (i.e. the compression by a condyle normally to the tissue surface under simultaneously tangential displacement, thus generating a tractional force due to tissue deformation). Although in in vivo studies it was shown that excessive plowing can lead to osteoarthritis, little quantitative experimental work on this loading modality and its mechanobiological effects is available in the literature. Therefore, a rolling/plowing explant test system has been developed to study the effect on pristine cartilage of plowing at different perpendicular forces. Cartilage strips harvested from bovine nasal septa of 12-months-old calves were subjected for 2h to a plowing-regime with indenter normal force of 50 or 100 N and a sliding speed of 10 mm s(-1). 50 N produced a tractional force of 1.2±0.3N, whereas 100 N generated a tractional force of 8.0±1.4N. Furthermore, quantitative-real-time polymerase chain reaction experiments showed that TIMP-1 was 2.5x up-regulated after 50 N plowing and 2x after 100 N plowing, indicating an ongoing remodeling process. The expression of collagen type-I was not affected after 50 N plowing but it was up-regulated (6.6x) after 100 N plowing, suggesting a possible progression to an injury stage of the cartilage, as previously reported in cartilage of osteoarthritic patients. We conclude that plowing as performed by our mimetic system at the chosen experimental parameters induces changes in gene expression depending on the tractional force, which, in turn, relates to the applied normal force. . 50 N produced a tractional force of 1.2 ± 0.3 N, whereas 100 N generated a tractional force of 8.0 ± 1.4 N. Furthermore, quantitativereal-time polymerase chain reaction experiments showed that TIMP-1 was 2.5x upregulated after 50 N plowing and 2x after 100 N plowing, indicating an ongoing remodeling process. The expression of Collagen type I was not affected after 50 N plowing but it was up-regulated (6.6x) after 100 N plowing, suggesting a possible progression to an injury stage of the cartilage, as previously reported in cartilage of osteoarthritic patients. We conclude that plowing as performed by our mimetic system at the chosen experimental parameters induces changes in gene expression depending on the tractional force, which, in turn, relates to the applied normal force.

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Section: Introductionmentioning

confidence: 99%

Coupling plowing of cartilage explants with gene expression in models for synovial joints

Correro-Shahgaldian

Colombo

Spencer

et al. 2011

Journal of Biomechanics

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“…The structure of TMJ, particularly of the disc, under light microscopy has been described as composed of collagen and elastic fibres with chondroid cells [14][15][16]. The TMJ structures are mainly covered with fibrous cartilage.…”

Section: Pathology Of Temporomandibular Jointmentioning

confidence: 99%

Inflammatory markers in temporomandibular joint disorders

Kostrzewa-Janicka¹,

Jurkowski²,

Nędzi-Góra³

et al. 2012

cejoi

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“…FEA of these models can provide useful information about contact stresses that possibly contribute to dysfunction of the mandible and the TMJ. Patient-specific FEMs are expected to add another dimension to TMD diagnosis, which is currently based on clinical, radiographic and morphological evaluations (Singh and Detamore, 2009). …”

Section: Anatomical Modeling and Finite Element Analysismentioning

confidence: 99%

“…For balanced load simulation, 200N force was applied in vertically upward direction on the second molar on both sides of the mandible. During parafunctional activities, loading conditions are different from those under normal loading (Singh and Detamore, 2009). To simulate unbalanced loading, same location and orientation of force were used with 250N on the left second molar and 200N on the right second molar of the mandible.…”

Section: Model 2 -Feamentioning

confidence: 99%