Biomechanical Properties of Hip Cartilage in Experimental Animal Models

Athanasiou, K. A.; Agarwal, Animesh; Muffoletto, Anthony J.; Dzida, F. J.; Constantinides, Georgios; Clem, Michael F.

doi:10.1097/00003086-199507000-00035

Cited by 133 publications

(120 citation statements)

References 0 publications

Supporting

Mentioning

116

Contrasting

Order By: Relevance

“…In general, the theoretical creep consolidation curves closely fit the observed experimental data, and were qualitatively similar to the creep responses for cartilage and meniscus. The average intrinsic compressive modulus of the bovine labrum is approximately one-quarter to onehalf that reported for bovine articular cartilage [2,20], and is similar to that reported for the bovine meniscus [15,21]. The average permeability of the labrum tissue was much lower than that reported for bovine articular cartilage [2,20], and also lower than that observed in the bovine meniscus [15,21].…”

Section: Labrum Regionsupporting

confidence: 64%

“…The average intrinsic compressive modulus of the bovine labrum is approximately one-quarter to onehalf that reported for bovine articular cartilage [2,20], and is similar to that reported for the bovine meniscus [15,21]. The average permeability of the labrum tissue was much lower than that reported for bovine articular cartilage [2,20], and also lower than that observed in the bovine meniscus [15,21]. The low permeability and aggregate modulus of the labrum greatly influence its creep response, with a correspondingly large time constant, as evidenced by the long time (-36000 s) required for the tissue to reach its equilibrium displacement.…”

Section: Labrum Regionmentioning

confidence: 80%

“…Confined compression testing apparatus. The cylindrical labrum plug ( I ) is seated in an impermeable confining chamber (2). A step load, weights lowered by a stepper motor ( 3 ) , is applied from above through a porous sintered metal piston (4).…”

Section: (A)mentioning

confidence: 99%

“…6). A thermocouple in the PBS solution (1) is held between two spring-loaded clamps (2). The lower clamp is fixed to the stationary lnstron testing frame (3), while the upper clamp is fixed to a 100 N load cell mounted on the moving Intron cross-head (4).…”

Section: S J Fergiiwn ('1 Id I Journul Qf Ovthojiucclic Reseurclimentioning

confidence: 99%

See 3 more Smart Citations

The material properties of the bovine acetabular labrum

Ferguson

Bryant

Ito

2001

Journal Orthopaedic Research

View full text Add to dashboard Cite

The compressive and tensile material properties of the bovine acetabular labrum were measured. Confined compression testing was used to determine the aggregate compressive modulus and the permeability of the labrum. The compressive modulus of the labrum (0.157 & 0.057 MPa) is comparable to that of the morphologically similar meniscus, and approximately one-quarter to onehalf that of the adjoining acetabular cartilage. The permeability of the labrum (4.98 =k 3.43 x m'/N s) was lower than that of the meniscus and cartilage, with a significantly higher resistance to interstitial fluid flow across the acetabular rim than along the rim. Specimens from the posterior and superior regions of the labrum were tested to failure in uniaxial tension. The maximum stress at failure ( I I .9 i 6.1 MPa), maximuni strain at failure (26.5 i 7.6%) and tangent modulus (74.7 * 44.3 MPa) were similar to those reported for the bovine meniscus, and to other tissues composed of highly oriented collagen fiber bundles. In tension, the labrum is much stiffer (10-1 5x) than the adjoining articular cartilage, and the posterior region of the labrum is significantly stiffer (45'%) than the superior region. The labrum's low permeability may contribute to sealing of the hip joint. The high circumferential tensile stiffness of the labrum, together with its ring structure, reinforce the acetabular rim and may contribute to joint stability.

show abstract

Section: Labrum Regionsupporting

confidence: 64%

Section: Labrum Regionmentioning

confidence: 80%

Section: (A)mentioning

confidence: 99%

Section: S J Fergiiwn ('1 Id I Journul Qf Ovthojiucclic Reseurclimentioning

confidence: 99%

See 2 more Smart Citations

The material properties of the bovine acetabular labrum

Ferguson

Bryant

Ito

2001

Journal Orthopaedic Research

View full text Add to dashboard Cite

show abstract

“…The Young's modulus of the PCM is chosen to be = 15 kPa [29,31], unless specifically stated otherwise. Based on previous studies, the Young's modulus of the ECM is chosen to be = 1.1 MPa [32,33]. The Poisson's ratio is 0.4 for the ECM [34] and 0.125 for the PCM [15].…”

Section: Isotropic Hyperelasticitymentioning

confidence: 99%

Computational investigation of in situ chondrocyte deformation and actin cytoskeleton remodelling under physiological loading

2013

View full text Add to dashboard Cite

Perspectives: A proposed general model of the “mechanostat” (suggestions from a new skeletal-biologic paradigm)

Frost

1996

Anat. Rec.

171

View full text Add to dashboard Cite

This provisional general model for the skeleton's mechanostat spans the biologic “distance” between the organ and macromolecule. It could apply to bone, cartilage and fibrous tissue, and to bones, joints, ligaments and other organs made wholly or in part from the basic tissues. It suggests where small things such as a cytokine effect on some cell should fit in the overall scheme of skeletal physiology. It proposes that interlocking negative feedback loops provide mechanical‐usage‐dedicated message traffic routes on which nonmechanical agents could act to optimize or impair postnatal skeletal adaptations to varied mechanical and nonmechanical challenges, and treatments of disease too. It suggests that future research must try to understand the mechanostat's cell‐ and molecular‐biologic roots. © 1996 Wiley‐Liss, Inc.

show abstract

Biomechanical Properties of Hip Cartilage in Experimental Animal Models

Cited by 133 publications

References 0 publications

The material properties of the bovine acetabular labrum

The material properties of the bovine acetabular labrum

Computational investigation of in situ chondrocyte deformation and actin cytoskeleton remodelling under physiological loading

Perspectives: A proposed general model of the “mechanostat” (suggestions from a new skeletal-biologic paradigm)

Contact Info

Product

Resources

About