Biomechanical profile of the cornea in primary congenital glaucoma

Gatzioufas, Zisis; Labiris, Georgios; Stachs, Oliver; Hovakimyan, Marina; Schnaidt, A.G.; Viestenz, Arne; Käsmann‐Kellner, Barbara; Seitz, Berthold

doi:10.1111/j.1755-3768.2012.02519.x

Cited by 52 publications

(39 citation statements)

References 39 publications

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“…2 Another common finding of PCG is corneal opacification or haze, while the corneal biomechanical profile is also significantly modified in PCG. 3,4 PCG has been associated with mutations in the gene CYP1B1 and LTBP2m. 5 Isolated dysgenesis of the trabecular meshwork has been identified as the anatomical cause of PCG, but the underlying pathophysiology is still obscure.…”

Section: Introductionmentioning

confidence: 99%

Corneal sensitivity and morphology of the corneal subbasal nerve plexus in primary congenital glaucoma

Gatzioufas

Labiris

Hafezi

et al. 2014

Eye

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Background To quantify the corneal subbasal nerve density and the total number of nerve fibers in primary congenital glaucoma (PCG) and to evaluate their impact on corneal sensitivity. Methods Forty eyes of 26 PCG patients were compared with 40 eyes randomly selected from 40 non-glaucoma patients who populated the control group. Central corneal sensitivity (CCS) was assessed by means of Cochet-Bonnet esthesiometry. The mean subbasal nerve density and the total number of nerve fibers were quantified by laserscanning confocal microscopy. Normality of data was assessed by Kolmogorov-Smirnov testing. Differences in parameters were assessed with Student's t-test, while correlations with CSS were assessed with Pearson's correlation. Results Significant differences were identified in the mean subbasal nerve density (2108 ± 692 mm in PCG, 2642 ± 484 mm in controls, P ¼ 0.003) and in the total number of nerve fibers (12.3±4.2 in PCG, 15.4±3.1 in controls, P ¼ 0.02). Both groups presented comparable mean CCS and tortuosity. Both groups presented strong correlations between CCS and mean nerve density (r ¼ 0.57 in PCG, r ¼ 0.67 in controls, all Po0.05), and between CCS and total number of nerve fibers (r ¼ 0.55 in PCG, r ¼ 0.56 in controls, all Po0.05). Conclusion PCG exerts significant changes in both the mean subbasal nerve density and the total number of nerve fibers. However, these changes do not appear to affect central corneal sensitivity.

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Section: Introductionmentioning

confidence: 99%

Corneal sensitivity and morphology of the corneal subbasal nerve plexus in primary congenital glaucoma

Gatzioufas

Labiris

Hafezi

et al. 2014

Eye

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“…Наиболее изученным из перечисленных па-раметров, характеризующих эластичность и, со-ответственно, деформируемость глазного яблока в ответ на колебания собственно офтальмотону-са, с одной стороны, а также на аппланацию (или импрессию) в ходе офтальмотонометрии -с дру-гой, является центральная толщина роговицы [16,18,20,26,39,51].…”

Section: Doi: 1017816/ov9323-31unclassified

“…Большинство авторов, отмечая это обстоятельство, вместе с тем сообщают, что еди-ное мнение по поводу динамики центральной тол-щины роговицы при врождённой глаукоме пока отсутствует [13,16,25,26,30,36,40,44,54,56,57]. Более подробно эти сведения рассмотре-ны ниже.…”

Section: Doi: 1017816/ov9323-31unclassified

“…Gatzioufas et al (2013) пришли к выво-ду, что корнеальный гистерезис и фактор рези-стентности роговицы у пациентов с врождённой глаукомой снижаются, отрицательно коррелируя с диаметром роговицы и положительно -с её центральной толщиной [26]. Логично предполо-жить, что снижение величин рассматриваемых параметров характеризует повышение эластич-ности фиброзной капсулы глаза и, соответствен-но, объясняет ложно заниженные результаты офтальмотономет рии.…”

Section: Doi: 1017816/ov9323-31unclassified

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Features of measurement of intraocular pressure in children

Tugeeva

Эльдаровна²,

Brzheskiy

et al. 2016

Ophthalmology Reports

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This review discusses the results of various studies conducted in recent years on the comparison of modern methods of measuring intraocular pressure (IOP) in children: pneumotonometry, Maklakov applanation tonometry, and tonometry using Perkins tonometer, Goldmann tonometer, Icare tonometer, Ocular Response Analyzer, TonoPen handheld tonometer, transpalpebral tonometer TIOP01, or a dynamic contour Pascal tonometer. This study discusses the advantages and disadvantages of different methods of measurement of IOP in children, including the evaluation of patients with fibrous lens capsules that might affect the measurement of IOP and an analysis of the characteristics of evaluation of IOP in children with congenital glaucoma.

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“…[40][41][42] A study by Yeh et al 43 found that Asians exhibited lower mean CH and CRF when compared with their non-Asian counterparts at baseline before orthokeratology treatment. This difference has been hypothesized as a factor in explaining why Asian corneas are more difficult to deform from their baseline state and are likely to rebound to baseline much quicker than non-Asian corneas during overnight orthokeratology treatment.…”

Section: Corneamentioning

confidence: 99%

Accounting for Ethnicity-Related Differences in Ocular Surface Integrity as a Step Toward Understanding Contact Lens Discomfort

Chan

Svitova

Lin³

2017

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Contact lens discomfort is a common problem that can lead to unsuccessful or limited contact lens wear. Although many factors may contribute to contact lens discomfort, limited research has explored the influence of ethnicity-related differences in the anatomy and physiology of the ocular surface. Therefore, we performed a search of the literature in PubMed using key words related to “ocular surface” paired with the terms “race” and “ethnicity.” The goal of this review was to determine potential areas of research regarding ethnicity differences, particularly between Asian and non-Asian eyes, in ocular surface integrity to advance our understanding of contact lens discomfort.

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Biomechanical profile of the cornea in primary congenital glaucoma

Abstract: ABSTRACT.Purpose: The aim of our study was to investigate the biomechanical properties of the cornea in primary congenital glaucoma (PCG) and to identify the potential ocular determinants, which affect the corneal biomechanical metrics.

Cited by 52 publications

References 39 publications

Corneal sensitivity and morphology of the corneal subbasal nerve plexus in primary congenital glaucoma

Corneal sensitivity and morphology of the corneal subbasal nerve plexus in primary congenital glaucoma

Features of measurement of intraocular pressure in children

Accounting for Ethnicity-Related Differences in Ocular Surface Integrity as a Step Toward Understanding Contact Lens Discomfort

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