Biomechanical Features of Reinforced Esophageal Hiatus Repair in a Porcine Model

Amigo, Natalia; Zubieta, Cecilia; Riganti, Juan Martin; Ramirez, Mauricio; Renda, Pedro; Lovera, Romina; Pascaner, Ariel; Vigliano, Carlos; Craiem, Damián; Young, Daniel A.; Gilbert, Thomas W.; Nieponice, Alejandro

doi:10.1016/j.jss.2019.08.026

Cited by 4 publications

(3 citation statements)

References 40 publications

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Section: Discussionmentioning

confidence: 99%

“…They postulated that UBM was more appropriate for HH repair on the grounds that it more accurately mimicked native tissue recovery properties with less evidence of foreign body-generated inflammation than PP or BTM. 16 Conversely, Norton performed insertion of BTM into the hind leg biceps of Sprague Dawley rats and compared 7-and 14-day postoperative histologic findings from collagen tissue matrix vs BTM (GORE ® , BIO-A ® Tissue Reinforcement). Biosynthetic tissue matrix demonstrated increased vascularity and granulation tissue with decreased lymphocytic and histiocytic infiltrate, as well as better incorporation into surrounding tissue than collagen tissue matrix at 7 days.…”

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confidence: 99%

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Outcomes of Bariatric Surgery With Concomitant Hiatal Hernia Repair Using an Absorbable Tissue Matrix

Love

Verna

Kothari

et al. 2021

The American Surgeon

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Background Hiatal hernias are a common finding in patients who undergo bariatric surgery with an incidence of about 20% of all bariatric patients. Controversy exists on the utility of a biosynthetic tissue matrix (BTM) usage in combination with crural repair. This study was designed to explore the safety and benefits of the use of a BTM during concomitant hiatal hernia repair with bariatric surgical procedures. Methods This was a retrospective chart review of bariatric surgical patients who underwent a concomitant hiatal hernia repair at a single practice at a tertiary academic medical center from January 2014 to February 2019. Results A total of 420 patients were reviewed. Hiatal BTM reinforcement, recurrence, and postoperative proton pump inhibitor use were reported by type of operation. Recurrence was higher in gastric bypass patients who underwent hiatal hernia repair with suture cruroplasty alone vs. those who also underwent hiatal BTM reinforcement (7.1% vs. 3.7%, P = .52) and significantly higher in gastric sleeve patients who underwent hiatal hernia repair with suture cruroplasty alone vs. those who also underwent hiatal BTM reinforcement (7.1% vs. .5%, P = .01). No patient required reoperation for hiatal hernia recurrence. Discussion Performing Roux-en-Y gastric bypass or vertical sleeve gastrectomy with concomitant hiatal hernia repair is safe and durable. Employing crural reinforcement with BTM may be of benefit in reducing recurrence rates of hiatal hernia, particularly in sleeve gastrectomy patients.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Outcomes of Bariatric Surgery With Concomitant Hiatal Hernia Repair Using an Absorbable Tissue Matrix

Love

Verna

Kothari

et al. 2021

The American Surgeon

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“…The most commonly assessed cells were macrophages (n = 9) followed by foreign body giant cells 6 and lymphocytes. 5 There 12 Unknown 10 15 60 Amigo et al 13 Unknown 3 Unknown 1.5 Eastwood et al 14 Unknown 2 Unknown Unknown Fig. 3 number of studies analysing various structural factors on histology was an equal division between cells assessed quantitatively and qualitatively (6 each).…”

Section: Histology-inflammatory Cellular Analysismentioning

confidence: 99%

A Systematic Review Examining the Experimental Methodology Behind In Vivo Testing of Hiatus Hernia and Diaphragmatic Hernia Mesh

Whitehead-Clarke

Beynon

Banks

et al. 2022

Journal of Gastrointestinal Surgery

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Introduction Mesh implants are regularly used to help repair both hiatus hernias (HH) and diaphragmatic hernias (DH). In vivo studies are used to test not only mesh safety, but increasingly comparative efficacy. Our work examines the field of in vivo mesh testing for HH and DH models to establish current practices and standards. Method This systematic review was registered with PROSPERO. Medline and Embase databases were searched for relevant in vivo studies. Forty-four articles were identified and underwent abstract review, where 22 were excluded. Four further studies were excluded after full-text review—leaving 18 to undergo data extraction. Results Of 18 studies identified, 9 used an in vivo HH model and 9 a DH model. Five studies undertook mechanical testing on tissue samples—all uniaxial in nature. Testing strip widths ranged from 1–20 mm (median 3 mm). Testing speeds varied from 1.5–60 mm/minute. Upon histology, the most commonly assessed structural and cellular factors were neovascularisation and macrophages respectively (n = 9 each). Structural analysis was mostly qualitative, where cellular analysis was equally likely to be quantitative. Eleven studies assessed adhesion formation, of which 8 used one of four scoring systems. Eight studies measured mesh shrinkage. Discussion In vivo studies assessing mesh for HH and DH repair are uncommon. Within this relatively young field, we encourage surgical and materials testing institutions to discuss its standardisation.

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Urinary Bladder Matrix Scaffolds Promote Pericardium Repair in a Porcine Model

Amigo

Riganti

Ramirez

et al. 2020

Journal of Surgical Research

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Biomechanical Features of Reinforced Esophageal Hiatus Repair in a Porcine Model

Cited by 4 publications

References 40 publications

Outcomes of Bariatric Surgery With Concomitant Hiatal Hernia Repair Using an Absorbable Tissue Matrix

Outcomes of Bariatric Surgery With Concomitant Hiatal Hernia Repair Using an Absorbable Tissue Matrix

A Systematic Review Examining the Experimental Methodology Behind In Vivo Testing of Hiatus Hernia and Diaphragmatic Hernia Mesh

Urinary Bladder Matrix Scaffolds Promote Pericardium Repair in a Porcine Model

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