Biomechanical failure properties and microstructural content of ruptured and unruptured abdominal aortic aneurysms

Raghavan, Madhavan L.; Hanaoka, Mauro; Kratzberg, Jarin; Higuchi, Maria de Lourdes; Silva, Erasmo Simão da

doi:10.1016/j.jbiomech.2011.06.004

Cited by 83 publications

(87 citation statements)

References 13 publications

(35 reference statements)

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“…Comparing failure behaviour, Raghavan et al performed uniaxial tension tests on ruptured and unruptured human abdominal aorta aneurysms in the axial direction [63]. The mean failure stress for unruptured aneurysms (0.95 ± 0.28 MPa) is similar to results reported here for all sample treatment types, but is closest to the values for glutaraldehyde and collagenase treated samples.…”

Section: Diseased Tissue Comparisonsupporting

confidence: 73%

Creating a model of diseased artery damage and failure from healthy porcine aorta

Noble

Smulders

Green

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

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Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/) eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse Unless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version -refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher's website. TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request.Creating a model of diseased artery damage and failure from healthy porcine aorta AbstractLarge quantities of diseased tissue are required in the research and development of new generations of medical devices, for example for use in physical testing. However, these are difficult to obtain. In contrast, porcine arteries are readily available as they are regarded as waste. Therefore, reliable means of creating from porcine tissue physical models of diseased human tissue that emulate well the associated mechanical changes would be valuable. To this end, we studied the effect on mechanical response of treating porcine thoracic aorta with collagenase, elastase and glutaraldehyde. The alterations in mechanical and failure properties were assessed via uniaxial tension testing. A constitutive model composed of the Gasser-Ogden-Holzapfel model, for elastic response, and a continuum damage model, for the failure, was also employed to provide a further basis for comparison [1,2]. For the concentrations used here it was found that: collagenase treated samples showed decreased fracture stress in the axial direction only; elastase treated samples showed increased fracture stress in the circumferential direction only; and glutaraldehyde samples showed no change in either direction. With respect to the proposed constitutive model, both collagenase and elastase had a strong effect on the fibre-related terms. The model more closely captured the tissue response in the circumferential direction, due to the smoother and sharper transition from damage initiation to complete failure in this direction. Finally, comparison of the results with those of tensile tests on diseased tissues suggests these treatments indeed provide a basis for creation of physical models of diseased arteries.

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Section: Diseased Tissue Comparisonsupporting

confidence: 73%

Creating a model of diseased artery damage and failure from healthy porcine aorta

Noble

Smulders

Green

et al. 2016

Journal of the Mechanical Behavior of Biomedical Materials

View full text Add to dashboard Cite

show abstract

“…The present model was an idealized model of an abdominal aorta lacking the non-uniformities in geometry in real patient data. A uniform wall thickness was chosen in aneurismal and non-aneurismal vessels, which were not realistic, especially in fully developed aneurysms [12,23,72]. Vessel wall remodeling during the development of an aneurysm was also disregarded in the study.…”

Section: Resultsmentioning

confidence: 99%

“…In computational simulations, vessel stress is calculated as a function of the vessel diameter [7,34], wall thickness [36,37], asymmetry [14,18,34,36], tortuosity [21], material property [17,24,29,38], calcification [15,22], intraluminal thrombus (ILT) [5,15,16,33], and blood flow [4, 9, 13, 14, 17, 20, 25, 26, 28-30, 32, 35-41]. Blood vessel strength is measured by ex vivo studies [11,12,23,31,44] or estimated by effective features such as ILT existence, sex, and genetic vulnerability [10]. Medical treatment techniques of aneurysms, mainly stent applications, are also investigated [35,40].…”

mentioning

confidence: 99%

Investigation of material modeling in fluid–structure interaction analysis of an idealized three-layered abdominal aorta: aneurysm initiation and fully developed aneurysms

Şimşek

Kwon

2015

J Biol Phys

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Different material models for an idealized three-layered abdominal aorta are compared using computational techniques to study aneurysm initiation and fully developed aneurysms. The computational model includes fluid-structure interaction (FSI) between the blood vessel and the blood. In order to model aneurysm initiation, the medial region was degenerated to mimic the medial loss occurring in the inception of an aneurysm. Various cases are considered in order to understand their effects on the initiation of an abdominal aortic aneurysm. The layers of the blood vessel were modeled using either linear elastic materials or Mooney-Rivlin (otherwise known as hyperelastic) type materials. The degenerated medial region was also modeled in either linear elastic or hyperelastic-type materials and assumed to be in the shape of an arc with a thin width or a circular ring with different widths. The blood viscosity effect was also considered in the initiation mechanism. In addition, dynamic analysis of the blood vessel was performed without interaction with the blood flow by applying time-dependent pressure inside the lumen in a three-layered abdominal aorta. The stresses, strains, and displacements were compared for a healthy aorta, an initiated aneurysm and a fully developed aneurysm. The study shows that the material modeling of the vessel has a sizable effect on aneurysm initiation and fully developed aneurysms. Different material modeling of degeneration regions also affects the stressstrain response of aneurysm initiation. Additionally, the structural analysis without considering FSI (called noFSI) overestimates the peak von Mises stress by 52% at the interfaces of the layers.

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“…This has been shown by Raghavan et al through studying a large number of AAA rupture cases [24]. However, the presence of spinal column was not considered in this work, which will be incorporated in future works.…”

Section: Resultsmentioning

confidence: 74%

Biomechanical prediction of abdominal aortic aneurysm rupture risk: Sensitivity analysis

Zhao¹,

Li²,

Gu³

2012

JBiSE

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Objectives: The purpose of this research is to determine the quantitative relationship between the peak wall stress of abdominal aortic aneurysm (AAA) and its clinical risk factors including its maximum diameter, asymmetry index, wall thickness and abnormal high blood pressure. Methods: The response surface experimental design with one response and four variables was used to design the experimental tests. Thirty experiments were performed through finite element analysis in order to obtain the designed response values. Results: A nonlinear multivariable regression function was developed based on the experimental data. Results demonstrated the inefficiency of traditional 5-cm criterion for estimating the rupture of AAA. The profound effect of wall thickness on the peak wall stress has been observed and validated by the existing publications. Conclusion: The conventional 5-cm criterion for estimating AAA rupture might induce biased prediction, and multiple clinical risk factors need to be considered in realistic clinical settings.

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Biomechanical failure properties and microstructural content of ruptured and unruptured abdominal aortic aneurysms

Cited by 83 publications

References 13 publications

Creating a model of diseased artery damage and failure from healthy porcine aorta

Creating a model of diseased artery damage and failure from healthy porcine aorta

Investigation of material modeling in fluid–structure interaction analysis of an idealized three-layered abdominal aorta: aneurysm initiation and fully developed aneurysms

Biomechanical prediction of abdominal aortic aneurysm rupture risk: Sensitivity analysis

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