Biomechanical effects of polyglecaprone fibers in a polypropylene mesh after abdominal and rectovaginal implantation in a rabbit

Ozog, Yves; Mazza, Edoardo; Ridder, Dirk De; Deprest, Jan

doi:10.1007/s00192-012-1739-6

Cited by 18 publications

(24 citation statements)

References 21 publications

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“…Their size also permits the creation of several defects in the same animal as well as the harvesting of larger tissue specimens. However, the vaginal exposure rate is about 50% …”

Section: Discussionmentioning

confidence: 99%

“…As published by the authors, exposure to vaginal level of prostheses implanted in rabbits is very common; this could be due to the presence of a thin epithelium with poor vascularization, which after a short dissection may predispose to severe problems in healing. The same authors concluded that the use of rabbits for prosthetic transvaginal implants, is associated with numerous technical difficulties making it unsuitable for use in biomechanical studies …”

Section: Discussionmentioning

confidence: 99%

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In vivo biomechanical properties of heavy versus light weight monofilament polypropylene meshes. Does the knitting pattern matter?

Bigozzi

Provenzano

Maeda

et al. 2015

Neurourology and Urodynamics

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The final mechanical behavior of PP mesh can be changed by its weight and knitting pattern. These properties may be useful in making more biocompatible prostheses for pelvic organ prolapse (POP) with less foreign material to maintain longitudinal vaginal elasticity and minimize sexual symptoms while maintaining transverse resistance (i.e., between vaginal fornixes) to prevent POP recurrence. Neurourol. Urodynam. 36:73-79, 2017. © 2015 Wiley Periodicals, Inc.

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“…Their size also permits the creation of several defects in the same animal as well as the harvesting of larger tissue specimens. However, the vaginal exposure rate is about 50% …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

In vivo biomechanical properties of heavy versus light weight monofilament polypropylene meshes. Does the knitting pattern matter?

Bigozzi

Provenzano

Maeda

et al. 2015

Neurourology and Urodynamics

View full text Add to dashboard Cite

show abstract

“…In addition, possible differences have been observed in wound healing in rabbits following vaginal surgery, as well as in the biomechanical findings after mesh‐augmented repair . Moreover, even in ideal circumstances, rabbit vaginal explants are relatively small, which makes appropriate uniaxial and, certainly, biaxial testing of the implants difficult to perform . For these reasons, we wanted to further explore the potential of experimental vaginal surgery in a larger animal model.…”

Section: Introductionmentioning

confidence: 99%

“…To assess the effect of a change in the dimensions of the material, a second group was implanted with meshes having initial dimensions of 35 × 35 mm. We used a hybrid lightweight mesh material we previously studied in detail in other animal models …”

Section: Introductionmentioning

confidence: 99%

Graft‐related complications and biaxial tensiometry following experimental vaginal implantation of flat mesh of variable dimensions

Manodoro

Endo

Uvin

et al. 2012

BJOG

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Population Twenty adult parous Texel ewes.Methods Sheep were implanted with Gynemesh M, a 28-g/m² polypropylene mesh reinforced with polyglecaprone fibres, under general anaesthesia. Dissection into the rectovaginal septum was performed to accommodate a flat 50 9 50 mm (n = 10) or 35 9 35 mm (n = 10) mesh, which was sutured to the underlying tissues. A 50 9 50 mm mesh was laid over a primarily sutured, fullthickness, 40-mm longitudinal abdominal wall incision. Sacrifice was at 60 days (n = 10) or 90 days (n = 5).Main outcome measures The occurrence of exposure, the degree of contraction and examination of the biomechanical properties of explants with a minimum radius of 32 mm via biaxial tensiometry.Results Insertion of a 50 9 50 mm mesh led to exposures in 30% (3/10) of cases, and the average contraction rate was 52 ± 14%. In the 35 9 35 mm implants, there were no exposures, and the contraction rate was 25 ± 26.3%. Vaginal explants with no GRCs and of sufficient size had biomechanical properties that were comparable with those of abdominal explants. ConclusionVaginal mesh insertion is associated with GRCs, such as exposure and contraction. Although other factors probably play a role, this study illustrates that mesh size may also induce these complications. In a vaginal surgery model, clinically occurring GRCs can be reproduced. In addition, biomechanics of uncomplicated vaginal explants are comparable with those measured on abdominal explants.

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“…Rabbits have also been used, and though their vagina is larger, the histologic structure is not well comparable to that of humans [5]. Also the dimensions are relatively small [6]. Non-human primates are closest to humans [7][8][9], however, their use in research has been nearly completely banned in Europe [10].…”

Section: Introductionmentioning

confidence: 99%

Morphological and Functional Changes in the Vagina following Critical Lifespan Events in the Ewe

Hympánová

Rynkevic

Urbánková

et al. 2019

Gynecol Obstet Invest

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Background/Aims: The ewe is increasingly being used as an animal model for pelvic floor disorders. The aim was to further characterize changes in the vaginal properties during its entire lifespan. Methods: Vaginal tissues were collected at different stages of reproductive life (neonatal, prepubescence, nulliparous, primiparous, multiparous, and menopausal; ≥6 ewes/group). Vaginal size, as well as active and passive biomechanics, was measured. Microscopy included thickness of glycogen, epithelium, lamina propria and muscularis thickness, densities of collagen, elastin, smooth muscle, and nerves. Results: Vaginal dimensions increase during adolescence, peak at reproductive levels, and decrease sharply after ovariectomy. One year after first delivery, the distal vagina gets more compliant, yet this is reversed later in life. The thickness of glycogen staining epithelial layers changed with puberty and menopause. The epithelium was markedly thicker after multiple deliveries. The thickness of lamina propria and muscularis increased in puberty and in nulliparous. Semi-quantitative collagen assessment demonstrated a lower collagen and higher elastin content after first and multiple deliveries. Conclusion: The changes in the ovine vaginal wall during representative moments of her lifespan parallel those observed in women.

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Biomechanical effects of polyglecaprone fibers in a polypropylene mesh after abdominal and rectovaginal implantation in a rabbit

Abstract: The addition of polyglecaprone fibers did not compromise the biomechanical properties nor did it prevent vaginal extrusion and contraction. The latter as well as some other limitations preclude the rabbit vagina to be a suitable model for biomechanical testing.

Cited by 18 publications

References 21 publications

In vivo biomechanical properties of heavy versus light weight monofilament polypropylene meshes. Does the knitting pattern matter?

In vivo biomechanical properties of heavy versus light weight monofilament polypropylene meshes. Does the knitting pattern matter?

Graft‐related complications and biaxial tensiometry following experimental vaginal implantation of flat mesh of variable dimensions

Morphological and Functional Changes in the Vagina following Critical Lifespan Events in the Ewe

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