Biomechanical characterization of human dura mater

Kegel, Dries De; Vastmans, Julie; Fehervary, Heleen; Depreitere, Bart; Sloten, Jos Vander; Famaey, Nele

doi:10.1016/j.jmbbm.2017.12.023

Cited by 46 publications

(49 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both theoretical and experimental studies have shown that the dura and cranial bone present rate-dependent material properties [30][31][32][33][34]. Although linear and hyperelastic models can approximate the behavior of dura and skull very well at each rate [31,35,36], they behave differently under various speeds of loading. For instance, Persson et al [31] tested dura mater under uniaxial tension at three various strain rates of 0.01, 0.1, and 1.0 s −1 .…”

Section: Introductionmentioning

confidence: 99%

“…The majority of biomechanical characterizations for human head organs have been performed within experiments in relatively low strain rates. Recently, De Kegel et al [35] conducted some experiments for human dura specimens within a strain rate of 1.0 s −1 . They have obtained a highly nonlinear behavior for dura and characterized its mechanical response using three different hyperelastic material models.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Strain Rates in the Brain, Brainstem, Dura, and Skull under Dynamic Loadings

Hosseini-Farid

Amiri-Tehrani-Zadeh

Ramzanpour

et al. 2020

MCA

View full text Add to dashboard Cite

Knowing the precise material properties of intracranial head organs is crucial for studying the biomechanics of head injury. It has been shown that these biological tissues are significantly rate-dependent; hence, their material properties should be determined with respect to the range of deformation rate they experience. In this paper, a validated finite element human head model is used to investigate the biomechanics of the head in impact and blast, leading to traumatic brain injuries (TBI). We simulate the head under various directions and velocities of impacts, as well as helmeted and unhelmeted head under blast shock waves. It is demonstrated that the strain rates for the brain are in the range of 36 to 241 s −1 , approximately 1.9 and 0.86 times the resulting head acceleration under impacts and blast scenarios, respectively. The skull was found to experience a rate in the range of 14 to 182 s −1 , approximately 0.7 and 0.43 times the head acceleration corresponding to impact and blast cases. The results of these incident simulations indicate that the strain rates for brainstem and dura mater are respectively in the range of 15 to 338 and 8 to 149 s −1 . These findings provide a good insight into characterizing the brain tissue, cranial bone, brainstem and dura mater, and also selecting material properties in advance for computational dynamical studies of the human head.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Strain Rates in the Brain, Brainstem, Dura, and Skull under Dynamic Loadings

Hosseini-Farid

Amiri-Tehrani-Zadeh

Ramzanpour

et al. 2020

MCA

View full text Add to dashboard Cite

show abstract

“…Currently, not all FE head models include a description of the meninges: of those that do (Horgan and Gilchrist, 2003 ; King et al, 2006 ; Kleiven, 2006 ; Chafi et al, 2009 ; Li et al, 2011 ), they often include a simplified linear response based on uniaxial tests performed by Galford and McElhaney ( 1970 ). There is a relative dearth of primary data on the mechanical properties of the meninges, and with the exception of Walsh et al ( 2018 ); De Kegal et al ( 2017 ) and MacManus et al ( 2017a ), all other studies have been conducted over 30 years ago (Galford and McElhaney, 1970 ; Van Noort et al, 1981a ; McGarvey et al, 1984 ; Bylski et al, 1986 ). Of these previous investigations, there are large variations in results which could be attributed to the nature of the testing protocol, the source of the meninges samples, storage of samples and insufficient sample sizes.…”

Section: Introductionmentioning

confidence: 99%

Mechanical Characterization and Modeling of the Porcine Cerebral Meninges

Pierrat

Carroll

Merle

et al. 2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

The cerebral meninges, made up of the dura, arachnoid , and pia mater , is a tri-layer membrane that surrounds the brain and the spinal cord and has an important function in protecting the brain from injury. Understanding its mechanical behavior is important to ensure the accuracy of finite element (FE) head model simulations which are commonly used in the study of traumatic brain injury (TBI). Mechanical characterization of freshly excised porcine dura-arachnoid mater (DAM) was achieved using uniaxial tensile testing and bulge inflation testing, highlighting the dependency of the identified parameters on the testing method. Experimental data was fit to the Ogden hyperelastic material model with best fit material parameters of μ = 450 ± 190 kPa and α = 16.55 ± 3.16 for uniaxial testing, and μ = 234 ± 193 kPa and α = 8.19 ± 3.29 for bulge inflation testing. The average ultimate tensile strength of the DAM was 6.91 ± 2.00 MPa (uniaxial), and the rupture stress at burst was 2.08 ± 0.41 MPa (inflation). A structural analysis using small angle light scattering (SALS) revealed that while local regions of highly aligned fibers exist, globally, there is no preferred orientation of fibers and the cerebral DAM can be considered to be structurally isotropic. This confirms the results of the uniaxial mechanical testing which found that there was no statistical difference between samples tested in the longitudinal and transversal direction ( p = 0.13 for μ, p = 0.87 for α). A finite element simulation of a craniotomy procedure following brain swelling revealed that the mechanical properties of the meninges are important for predicting accurate stress and strain fields in the brain and meninges. Indeed, a simulation using a common linear elastic representation of the meninges was compared to the present material properties (Ogden model) and the intracranial pressure was found to differ by a factor of 3. The current study has provided researchers with primary experimental data on the mechanical behavior of the meninges which will further improve the accuracy of FE head models used in TBI.

show abstract

“…There are a few fibroblasts in the dura mater and osteoblasts in the periosteum. Kegel reported that the average thickness of human dura mater is 1.06 ± 0.22 mm [3]. Noort examined the dura mater of 16 fresh human cadavers who died at 20 to 77 years of age.…”

mentioning

confidence: 99%

Research and application progress on dural substitutes

Wang¹,

Ao²

2019

Journal of Neurorestoratology

View full text Add to dashboard Cite

Dural defects are a common problem in clinical practice, and various types of dural substitutes have been used to deal with dural defects. These play an important role in dural repair. Dural substitutes have gradually reached researchers, neurosurgeons, and patients for approval. This article summarizes the structural characteristics of the dura mater and its regeneration after injury, and reviews the state of progress in research and application. It will provide a reference for the development and application of dural substitutes.

show abstract

Biomechanical characterization of human dura mater

Cited by 46 publications

References 38 publications

The Strain Rates in the Brain, Brainstem, Dura, and Skull under Dynamic Loadings

The Strain Rates in the Brain, Brainstem, Dura, and Skull under Dynamic Loadings

Mechanical Characterization and Modeling of the Porcine Cerebral Meninges

Research and application progress on dural substitutes

Contact Info

Product

Resources

About