Biomechanical characterization of a chronic type a dissected human aorta

Amabili, Marco; Arena, Goffredo; Balasubramanian, Prabakaran; Breslavsky, Ivan D.; Cartier, Raymond; Holzapfel, Gerhard; Kassab, Ali; Mongrain, Rosaire

doi:10.1016/j.jbiomech.2020.109978

Cited by 23 publications

(15 citation statements)

References 22 publications

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“…The predicted outcomes of these results are consistent with other studies that generated models from imaging modalities of patients who presented with aortic dissection over a certain period (>6 months). [22][23][24]62 The WSS and pressure contour at different phases during the pulsation cycle also show a good correlation with the previous results reported from CFD investigations. 7 Previous studies 22,23 have highlighted the importance of applying two-way FSI coupling, which has been included in this study along with several advancements: the inclusion of side branches, aortic arch tortuosity, material orthotropy, pulsatile blood flow profiles and nonlinear blood viscosity.…”

Section: Discussionsupporting

confidence: 88%

“…Due to no fibre exclusion being implemented into this constitutive model, I 4 and I 6 also contribute to compression. 62 The first invariant I 1 in Equation ( 2) represents the sum of the squares of the stretches of the three distinct directions. Using the uniaxial tests of layers in identical directions, we fitted them together into the constitutive model to identify the parameters.…”

Section: Aorta Materials Propertiesmentioning

confidence: 99%

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Fluid–structure interaction study for biomechanics and risk factors in Stanford type A aortic dissection

Wang

Ghayesh

Kotousov

et al. 2023

Numer Methods Biomed Eng

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Aortic dissection is a life-threatening condition with a rising prevalence in the elderly population, possibly as a consequence of the increasing population life expectancy. Untreated aortic dissection can lead to myocardial infarction, aortic branch malperfusion or occlusion, rupture, aneurysm formation and death. This study aims to assess the potential of a biomechanical model in predicting the risks of a non-dilated thoracic aorta with Stanford type A dissection. To achieve this, a fully coupled fluid-structure interaction model was developed under realistic blood flow conditions. This model of the aorta was developed by considering threedimensional artery geometry, multiple artery layers, hyperelastic artery wall, in vivo-based physiological time-varying blood velocity profiles, and non-Newtonian blood behaviours. The results demonstrate that in a thoracic aorta with Stanford type A dissection, the wall shear stress (WSS) is significantly low in the ascending aorta and false lumen, leading to potential aortic dilation and thrombus formation.The results also reveal that the WSS is highly related to blood flow patterns. The aortic arch region near the brachiocephalic and left common carotid artery is prone to rupture, showing a good agreement with the clinical reports. The results have been translated into their potential clinical relevance by revealing the role of the stress state, WSS and flow characteristics as the main parameters affecting lesion progression, including rupture and aneurysm. The developed model can be tailored for patient-specific studies and utilised as a predictive tool to estimate aneurysm growth and initiation of wall rupture inside the human thoracic aorta.

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Section: Discussionsupporting

confidence: 88%

Section: Aorta Materials Propertiesmentioning

confidence: 99%

Fluid–structure interaction study for biomechanics and risk factors in Stanford type A aortic dissection

Wang

Ghayesh

Kotousov

et al. 2023

Numer Methods Biomed Eng

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“…A major barrier here is the lack of material properties of TBAD due to the scarce availability of dissected aortic tissues for mechanical testing. However, recent studies by Amabili et al [51] of a chronic type A dissection and Kan et al [52] of type B aortic dissections provided valuable biomechanical details on which material property models can be built.…”

Section: Discussionmentioning

confidence: 99%

Evaluation and verification of patient-specific modelling of type B aortic dissection

Armour

Guo

Saitta

et al. 2022

Computers in Biology and Medicine

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“…the walls of the diseased aorta (especially under dissection). In the literature, there are few reports on this issue [ 11 – 17 ]; those mainly concern the properties of the aortic wall with an aneurysm, but not with dissection. However, without knowing what loads the weakened walls of the dissected aorta can withstand, we cannot determine what should be the values of stiffness and oversizing for the potential stent-graft.…”

Section: Discussionmentioning

confidence: 99%

Ab ovo: Factors Affecting the Radial Stiffness of Thoracic Aorta Stent-Grafts

Zhuravleva¹,

Timchenko²,

Vladimirov³

et al. 2021

Sovrem Tehnol Med

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The aim of the investigation was to study the factors influencing the radial stiffness of the thoracic aorta stent-grafts with the stent elements made of nitinol tubes by laser cutting and thermal shape setting. Materials and Methods. The work used stent elements made by different technologies by two different manufacturers from a nitinol tube with a wall thickness of 0.5 mm (E1) and 0.4 mm (E2), with a final diameter of 20 mm. Height of cells E1-15 mm, E2-12.5 mm. The stents were manually attached to a tubular woven non-crimped base (PTGO Sever, Russia) with a 6/0 suture, resulting in either single or continuous stitches. In the RLU124 radial force tester (Blockwise Engineering LLC, USA), each of the four stent-grafts, as well as their individual stent elements, were compressed by 10 mm from the initial diameter. The dependence of the radial forces on deformation under loading and unloading was graphically presented. The temperature and enthalpy of phase transitions of nitinols into the austenite (Af) and martensitic (Mf) phases were studied using differential scanning calorimetry (DSC-3; Mettler Toledo, USA). All indicators were compared with the characteristics of two commercial models-Cronus (China) and E-vita Open Plus (Germany). Results. Four prototypes of SibHybrid stent-grafts were tested; those differed in their stent elements, distances between them, and the type of sutures (single or continuous). The stent elements of the models studied differed in the values of Af, Mf, and the enthalpy of phase transitions of nitinols. The hardest stent was the E2 prototype. The fixation of stent elements to the woven fabric in the graft increased the radial force by 4.0-5.5 times. During compression by 50 and 20% of the original diameter, the SibHybrid models developed radial force 4.5-6.0 times greater compared with the E-vita Оpen Plus model. The radial force values of SibHybrid models were almost the same as for the Cronus and models at 20% compression. Using continuous twining round suturing increased the radial force by about 10 N; accordingly, SibHybrid E2 had the highest radial force because it was fixed by a continuous suture. The density of the stent elements fixed on the fabric did not affect the radial force of the stent-graft as a whole. Conclusion. In the manufacture of stent elements from nitinol tubes, the main factor determining the radial stiffness is the technology of nitinol shape setting. With the standard technology of thermal shape setting, radial force can be changed by varying the height of the structure cell element and the cross-sectional area of the cell bars, as well as the suturing technique.

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Biomechanical characterization of a chronic type a dissected human aorta

Cited by 23 publications

References 22 publications

Fluid–structure interaction study for biomechanics and risk factors in Stanford type A aortic dissection

Fluid–structure interaction study for biomechanics and risk factors in Stanford type A aortic dissection

Evaluation and verification of patient-specific modelling of type B aortic dissection

Ab ovo: Factors Affecting the Radial Stiffness of Thoracic Aorta Stent-Grafts

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