Biomechanical characteristics of bioabsorbable magnesium-based (MgYREZr-alloy) interference screws with different threads

Ezechieli, Marco; Ettinger, Max; König, Carolin; Weizbauer, Andreas; Helmecke, Patrick; Schavan, Robert; Lucas, Arne

doi:10.1007/s00167-014-3325-6

Cited by 43 publications

(38 citation statements)

References 25 publications

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“…All the mentioned methods have been widely investigated for examining the in vivo and in vitro characteristics of common implant devices such as screws, plates, and pins [106][107][108]. In addition to the clinical trials of McBride and Verbrugge [109], at the first half of the 20th century, to employ Mg screws, plates and nails, recently, a few researchers [110,111] developed Mg-based implant devices and utilized them in patients'0 body to fix the bone fractures. Although plenty of studies has investigated the application of BP materials for manufacturing K-wires and cerclage wires, less attention has been paid to develop BMs for these wire bone fixation devices.…”

Section: Recent Developments Of Bm Wires In Bone Applicationsmentioning

confidence: 99%

Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Asgari

Hang

Chang

et al. 2018

Metals

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Abstract:Owing to significant advantages of bioactivity and biodegradability, biodegradable metallic materials such as magnesium, iron, and zinc and their alloys have been widely studied over recent years. Metallic wires with superior tensile strength and proper ductility can be fabricated by a traditional metalworking process (drawing). Drawn biodegradable metallic wires are popular biodegradable materials, which are promising in different clinical applications such as orthopedic fixation, surgical staples, cardiovascular stents, and aneurysm occlusion. This paper presents recent advances associated with the application of biodegradable metallic wires used in dental and orthopedic fields. Furthermore, the effects of some parameters such as the surface modification, alloying elements, and fabrication process affecting the degradation rate as well as biocompatibility, bioactivity, and mechanical stability are reviewed in the most recent works pertaining to these materials. Finally, possible pathways for future studies regarding the production of more efficient biodegradable metallic wires in the regeneration of bone defects are also proposed.

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Section: Recent Developments Of Bm Wires In Bone Applicationsmentioning

confidence: 99%

Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Asgari

Hang

Chang

et al. 2018

Metals

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“…Among the various biodegradable materials, magnesium (Mg) and Mgcontaining alloys have a long history in the musculoskeletal field [7]. Based on their high biocompatibility, biodegradability, and similar mechanical properties to bone, many studies investigated the use of Mg and its alloys for applications in orthopedic surgery [8][9][10][11][12][13][14][15][16][17]. In addition to its favorable mechanical properties, Mg has been shown to increase osteoblast differentiation in vitro [18,19] and to induce new bone formation in vivo [13], demonstrating a high osteogenic potential.…”

Section: Introductionmentioning

confidence: 99%

“…In addition to its favorable mechanical properties, Mg has been shown to increase osteoblast differentiation in vitro [18,19] and to induce new bone formation in vivo [13], demonstrating a high osteogenic potential. Furthermore, as screws for hallux valgus surgery, Mg-based implants are already in use for clinical applications [10,20]. However, these implants are much smaller than intramedullary nails and are not entirely surrounded by bone marrow, an environment that might affect implant degradation and tissue response.…”

Section: Introductionmentioning

confidence: 99%

Intramedullary Mg2Ag nails augment callus formation during fracture healing in mice

Jähn¹,

Saito

Taipaleenmäki

et al. 2016

Acta Biomaterialia

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Intramedullary stabilization is frequently used to treat long bone fractures. Implants usually remain unless complications arise. Since implant removal can become technically very challenging with the potential to cause further tissue damage, biodegradable materials are emerging as alternative options. Magnesium (Mg)-based biodegradable implants have a controllable degradation rate and good tissue compatibility, which makes them attractive for musculoskeletal research. Here we report for the first time the implantation of intramedullary nails made of an Mg alloy containing 2% silver (Mg2Ag) into intact and fractured femora of mice. Prior in vitro analyses revealed an inhibitory effect of Mg2Ag degradation products on osteoclast differentiation and function with no impair of osteoblast function. In vivo, Mg2Ag implants degraded under non-fracture and fracture conditions within 210 days and 133 days, respectively. During fracture repair, osteoblast function and subsequent bone formation were enhanced, while osteoclast activity and bone resorption were decreased, leading to an augmented callus formation. We observed a widening of the femoral shaft under steady state and regenerating conditions, which was at least in part due to an uncoupled bone remodeling. However, Mg2Ag implants did not cause any systemic adverse effects. These data suggest that Mg2Ag implants might be promising for intramedullary fixation of long bone fractures, a novel concept that has to be further investigated in future studies.

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“…Based on histological data and from implant pull out forces, bone conductive properties of magnesium alloy implants were observed and proposed to be mediated by magnesium hydroxides as well as by calcium phosphates present in the magnesium corrosion layer [17][18][19][20][21][22] .…”

Section: Introductionmentioning

confidence: 99%

Differential magnesium implant corrosion coat formation and contribution to bone bonding

Rahim

Weizbauer

Evertz

et al. 2016

J Biomedical Materials Res

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Magnesium alloys are presently under investigation as promising biodegradable implant materials with osteoconductive properties. To study the molecular mechanisms involved, the potential contribution of soluble magnesium corrosion products to the stimulation of osteoblastic cell differentiation was examined. However, no evidence for the stimulation of osteoblast differentiation could be obtained when cultured mesenchymal precursor cells were differentiated in the presence of metallic magnesium or in cell culture medium containing elevated magnesium ion levels. Similarly, in soft tissue no bone induction by metallic magnesium or by the corrosion product magnesium hydroxide could be observed in a mouse model. Motivated by the comparatively rapid accumulation solid corrosion products physicochemical processes were examined as an alternative mechanism to explain the stimulation of bone growth by magnesium-based implants. During exposure to physiological solutions a structured corrosion coat formed on magnesium whereby the elements calcium and phosphate were enriched in the outermost layer which could play a role in the established biocompatible behavior of magnesium implants. When magnesium pins were inserted into avital bones, corrosion lead to increases in the pull out force, suggesting that the expanding corrosion layer was interlocking with the surrounding bone. Since mechanical stress is a wellestablished inducer of bone growth, volume increases caused by the rapid accumulation of corrosion products and the resulting force development could be a key mechanism and provide an explanation for the observed stimulatory effects of magnesium-based implants in hard tissue.

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Biomechanical characteristics of bioabsorbable magnesium-based (MgYREZr-alloy) interference screws with different threads

Cited by 43 publications

References 25 publications

Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Intramedullary Mg2Ag nails augment callus formation during fracture healing in mice

Differential magnesium implant corrosion coat formation and contribution to bone bonding

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