Biomechanical characterisation of ovine spinal facet joint cartilage

Latif, Mohd Juzaila Abd; Zhang, Jin; Wilcox, Ruth K.

doi:10.1016/j.jbiomech.2012.03.015

Cited by 13 publications

(12 citation statements)

References 39 publications

(45 reference statements)

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“…These properties have been derived previously from experimental indentation tests using a computational model and iteratively altering the value of the cartilage properties until the predicted deformation–time curve matches that of the experimental test. 18 , 27 , 26 It is clear from the present study that such a deformation–time curve has a low sensitivity to the value of permeability. The maximum difference in the vertical displacement of the indenter was only 6.2%, compared to the initial curve, when the permeability decreased by 50%.…”

Section: Discussionmentioning

confidence: 64%

Comparison between FEBio and Abaqus for biphasic contact problems

Meng

Zhang

Fisher

et al. 2013

Proc Inst Mech Eng H

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Articular cartilage plays an important role in the function of diarthrodial joints. Computational methods have been used to study the biphasic mechanics of cartilage, and Abaqus has been one of the most widely used commercial software packages for this purpose. A newly developed open-source finite element solver, FEBio, has been developed specifically for biomechanical applications. The aim of this study was to undertake a direct comparison between FEBio and Abaqus for some practical contact problems involving cartilage. Three model types, representing a porous flat-ended indentation test, a spherical-ended indentation test, and a conceptual natural joint contact model, were compared. In addition, a parameter sensitivity study was also performed for the spherical-ended indentation test to investigate the effects of changes in the input material properties on the model outputs, using both FEBio and Abaqus. Excellent agreement was found between FEBio and Abaqus for all of the model types and across the range of material properties that were investigated.

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Section: Discussionmentioning

confidence: 64%

Comparison between FEBio and Abaqus for biphasic contact problems

Meng

Zhang

Fisher

et al. 2013

Proc Inst Mech Eng H

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“…In order to successfully engineer facet cartilage, it is critical that appropriate design criteria are established, which will ultimately provide the framework for the regeneration of a functional tissue replacement. Currently, there exist no experimental studies that characterize the biomechanical, biochemical, and histological properties of human cartilage, and only a few detailing the characteristics of animal facet cartilage [27,28]. With regard to the latter, the spines of quadrupeds receive different loading patterns when compared to bipeds, furthering the necessity for comparing the facet joints of humans and animals to develop suitable nonprimate animal models.…”

Section: Introductionmentioning

confidence: 99%

Characterization of facet joint cartilage properties in the human and interspecies comparisons

et al. 2017

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This work provides the first comprehensive description of the properties of lumbar facet joint cartilage. Importantly, this work establishes that histological, biochemical, and mechanical properties are comparable between bipedal and quadrupedal animals, helping to guide future selection of appropriate animal models. This work also suggests that the human facet joint is highly susceptible to pathology. The mechanical properties of facet cartilage, found to be inferior to those of other synovial joints, provide a greater understanding of the joint's structure-function relationships as well as the potential etiology of facet joint pathology. Lastly, this work will serve as the foundation for the development of much-needed facet joint treatments, especially those based on tissue engineering approaches.

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“…The SMZ is richly innervated and considered a source of pain (Buckland-Wright, 2004;Hayami et al, 2006;Intema et al, 2010) and computer models are often used to study the relationship between facet joint morphology and the mechanisms of lower back pain (Teo et al, 2004;Kuo et al, 2010). Improving both the anatomy and the mechanical properties in a model can enhance orthopedic treatment and surgery (Abd Latif et al, 2012;Niemeyer et al, 2012). For instance, the thickness of the SMZ is usually modeled as the thickness of the cortical shell [around 0.38 mm according to Eswaran et al (2005)], which is much thinner than this study suggests.…”

Section: Discussionmentioning

confidence: 99%

“…As osteoarthritis progresses, the load‐bearing role of the facet joints is altered (Adams and Hutton, ; Adams and Hutton, ; Yang and King, ); thus, facet joint sclerosis should affect SMZ thickness as much as SMZ tissue properties (i.e., BMD and porosity) and mechanical properties (i.e., modulus of elasticity). Whereas cartilage and trabecular bone have frequently been studied, few references concern the tissue and mechanical properties of facet joint SMZ (Jang and Kim, ; Abd Latif et al, ). Therefore, to provide reliable insights into the mechanism of osteoarthritic progression from CT scans, it is necessary to examine the morphology and biomechanical properties of the SMZ and their homogeneity within the facet joint.…”

Section: Introductionmentioning

confidence: 99%

Morphological and biomechanical analyses of the subchondral mineralized zone in human sacral facet joints: Application to improved diagnosis of osteoarthritis

et al. 2015

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The anatomy of the facet joint subchondral mineralized zone (SMZ) is the main parameter used in diagnosing osteoarthritis. Usually, a single CT scan slice is used to measure the thickness, but the measurement is highly location-dependent. Bone mineral density (BMD) and porosity could be more reliable than thickness for detecting SMZ sclerosis, and linking them to stiffness can provide insights into the mechanism of osteoarthritis progression. The goal of this study was two-fold: (1) to assess spatial heterogeneity in thickness, BMD, and porosity within the non-pathological human facet joint SMZ; (2) to correlate these measurements with the static modulus of elasticity (MOEsta ). Four non-pathological facet joints were excised and imaged using micro-computed tomography (µCT) to measure SMZ thickness, BMD, and porosity. A total of eight parallelepiped SMZ samples were similarly analyzed and then mechanically tested. The mean SMZ BMD, porosity, and thickness (± Standard Deviation) of the whole facet joints were 611 ± 35 mgHA/cc, 9.8 ± 1.3%, and 1.39 ± 0.41 mm, respectively. The mean BMD, porosity, and MOEsta of the eight SMZ samples were 479 ± 23 mgHA/cc, 12 ± 0.01%, and 387 ± 138 MPa, respectively, with a positive rank correlation between BMD and porosity. BMD and porosity were more homogeneous within the facet joint than thickness and they could be more reliable parameters than thickness for detecting SMZ sclerosis. The values for the physiological SMZ and MOEsta of human facets joints obtained here were independent of BMD. SMZ BMD and porosity were related to each other.

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Biomechanical characterisation of ovine spinal facet joint cartilage

Cited by 13 publications

References 39 publications

Comparison between FEBio and Abaqus for biphasic contact problems

Comparison between FEBio and Abaqus for biphasic contact problems

Characterization of facet joint cartilage properties in the human and interspecies comparisons

Morphological and biomechanical analyses of the subchondral mineralized zone in human sacral facet joints: Application to improved diagnosis of osteoarthritis

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